Incidence of Childhood Eosinophilic Esophagitis in Central Brazil: How Many Are We Missing?

Abstract

The incidence of EoE in the present study was similar to that reported in the literature. However, these data may be underestimated owing to difficulties accessing UGE. Increased knowledge of esophageal eosinophilic diseases in childhood requires associated improvements in health infrastructure.

Systematic review with meta‐analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population‐based studies

“…Most of the studies of the prevalence of EoE were conducted in United States (US), Canada and Europe, but there were also studies from Western Australia, and South America . Key differences in prevalence rates depended on whether the study population included only children, only adults or individuals of all ages, as well as on the time the study was undertaken and the definition of prevalence such as a point (16 studies or a period (11 studies); and methodology used, such as hospital‐based case series (14 studies), administrative database (7 studies), or insurance database (8 studies) (Table S1). Further variation was related to the definition of EoE considered by the various authors, which differed significantly over the period with regard to the role of pH‐monitoring and consideration of PPIs in the diagnostic and therapeutic algorithm of the disease …”

“…Studies based on insurance and administrative databases, confined to those aged under 16 years, reported the same prevalence provided by hospital‐based case series (Table ). According the three most recently published studies following the most up‐to‐date diagnostic criteria for EoE, the current prevalence for EoE in children is 53.4 cases/100 000 inhabitants (95% CI, 27.1‐88.5; I 2 = 95.6%). There was a nonsignificant trend towards a higher prevalence of EoE among the studies with a lower risk of bias (42.7; 95% CI, 14.1‐86.8 vs 28.2; 95% CI, 16.4‐43.3)…”

“…There were 10 studies of the incidence of EoE in children; these were conducted in the US, Denmark, Spain and Brazil over a 14‐year period, with data from 1991 to the end of 2017 (Table S1). It was found that the incidence of EoE in children for the whole period was 6.6/100 000 persons‐year; 95% CI 3‐11.7; I 2 = 99.8%), but 5.6; 95% CI, 2.6‐9.8; I 2 = 96.6% when only the most recent studies were considered, thus supporting stable incidence rates for EoE over time (Figure B).…”

“…We also aimed to update the figures provided by our previous systematic review, which summarised publications up to the end of 2014; with the expanding recognition of EoE, a sharp increase in numbers of reported cases, together with the 17 population‐based studies released since 2014/5 (which represent half of the documents included in this systematic review), determined that previous results were obsolete. Furthermore, the recent update of diagnostic criteria for EoE, by eliminating proton pump inhibitor‐responsive oesophageal eosinophilia (PPI‐REE) as a different entity and including these patients within the clinical spectrum of EoE, required an update of the data in order to reflect the magnitude of the problem, especially since several recent population studies had already applied the new diagnostic criteria …”

Biomarcadores de comprometimento da barreira epitelial esofágica em crianças e adolescentes com esofagite eosinofílica

“…Nos países nórdicos da América e Europa, a incidência tem sido relatada em 6 a 13 casos /100000 habitantes (ARIAS; LUCENDO, 2013). Em um estudo de metaanálise publicado por Arias e colaboradores em 2016, a incidência agrupada foi de 3,7 casos/100.000 habitantes por ano com intervalo de confiança de 95%: 1,7-6,5 (ARIAS et al, 2016 (FERREIRA et al, 2008;GONÇALVES et al, 2018).…”