Incidence of Central Nervous System Tumors in Gironde, France

Elia-Pasquet, S.; Provost, D.; Jaffré, Anne; Loiseau, Hugues; Vital, Anne; Kantor, G.; Maire, Jean-Philippe; Dautheribes, M.; Darrouzet, V.; Dartigues, Jean‐François; Brochard, Patrick; Baldi, Isabelle

doi:10.1159/000075953

Cited by 76 publications

(16 citation statements)

References 23 publications

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“…4,5,6). Patients with meningiomas (mean age 64.7 ± 11.4 years) were significantly older than patients with Schwannomas (mean age 53.5 ± 15.8 years), who were significantly older than patients with ependymomas (mean age 46.6 ± 18.1).…”

Section: Tumor Locationmentioning

confidence: 99%

“…Primary spinal cord tumors are one of the rarest categories of tumors, representing about 4-16 % of all tumors arising from the central nervous systems (CNS) according to previous reports [1][2][3][4][5][6][7][8][9][10][11][12][13]. Because of variation in population sizes studied and classification of tumors, the frequencies of different spinal cord tumors vary among these reports.…”

Section: Introductionmentioning

confidence: 99%

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Primary spinal cord tumors: review of 678 surgically treated patients in Japan. A multicenter study

et al. 2012

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Purpose To clarify the relative frequency of various histopathological primary spinal cord tumors and their features in Japanese people and to compare this data with other reports. Methods Primary spinal cord tumor surgical cases from 2000 to 2009, which were registered in our affiliated hospital database were collected. We examined age at surgery, sex, anatomical location, vertebral level of the tumor, and pathological diagnosis in each case.Results Of the 678 patients in our study, 377 patients (55.6 %) were males and 301 patients (44.4 %) were females (male/female ratio 1.25). The mean age at surgery was 52.4 years. Of these tumors, 123 cases (18.1 %) were intramedullary, 371 cases (54.7 %) were intradural extramedullary, 28 cases (4.1 %) were epidural, and 155 cases (22.9 %) were dumbbell tumors. The pathological diagnoses included 388 schwannomas (57.2 %), 79 meningiomas (11.6 %), 54 ependymomas (8.0 %), 27 hemangiomas (4.0 %), 23 hemangioblastomas (3.4 %), 23 neurofibromas (3.4 %), and 9 astrocytomas (1.3 %). The male/female ratios for schwannomas, meningiomas, ependymomas,Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan e-mail: imagama@med.nagoya-u.ac.jp K. Sato Department of Orthopaedic Surgery, Nagoya Daini Red Cross Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya 466-8650, Japan (2012( ) 21:2019( -2026( DOI 10.1007( /s00586-012-2345 hemangiomas, hemangioblastomas, neurofibromas, malignant lymphomas, and lipomas are 1.4, 0.34, 1.3, 1.5, 2.3, 1.3, 2.7 and 2.3, respectively. Conclusion This is the first published research in English on the epidemiology of primary spinal cord tumors in Japanese people. Similar to other reports from Asian countries, our data indicates a higher male/female ratio overall for spinal cord tumors, a higher proportion of nerve sheath cell tumors, and a lower proportion of meningiomas and neuroepithelial tumors compared to reports from non-Asian countries. Data in the current study represent the characteristics of primary spinal cord tumors in Asian countries.

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Section: Tumor Locationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary spinal cord tumors: review of 678 surgically treated patients in Japan. A multicenter study

et al. 2012

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“…The relative rarity of primary malignant and nonmalignant spine tumors limits research, treatment decisions, and health care planning related to this condition2,4,5,10). It is important to determine the epidemiology of primary spine tumor accurately for decision-making regarding treatment and for research and health care planning3,6,13,15).…”

Section: Introductionmentioning

confidence: 99%

“…Several population-based incidence rates of spine tumor have been reported4,7,10,13,15,17). Among these population-based studies, there have been 2 nation-wide studies in Korea7,17).…”

Section: Introductionmentioning

confidence: 99%

A Nation-Wide Epidemiological Study of Newly Diagnosed Primary Spine Tumor in the Adult Korean Population, 2009-2011

Sohn

Kim

Chung

et al. 2017

J Korean Neurosurg Soc

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ObjectiveThis 2009–2011 nation-wide study of adult Koreans was aimed to provide characteristics, medical utilization states, and survival rates for newly diagnosed patients with primary nonmalignant and malignant spine tumors.MethodsData for patients with primary spine tumors were selected from the Korean Health Insurance Review and Assessment Service database. The data included their age, sex, health insurance type, co-morbidities, medical cost, and hospital stay duration. Hospital stay duration and medical costs per person occurring in one calendar year were used. In addition, survival rates of patients with primary malignant spine tumors were evaluated.ResultsThe incidence rate of a primary spine tumor increased with age, and the year of diagnosis (p≤0.0001). Average annual medical costs ranged from 1627 USD (pelvis & sacrum & coccyx tumors) to 6601 USD (spinal cord tumor) for primary nonmalignant spine tumor and from 12137 USD (spinal meningomas) to 20825 USD (pelvis & sacrum & coccyx tumors) for a primary malignant spine tumor. Overall survival rates for those with a primary malignant spine tumor were 87.0%, 75.3%, and 70.6% at 3, 12, and 24 months, respectively. The Cox regression model results showed that male sex, medicare insurance were significantly positive factors affecting survival after a diagnosis of primary malignant spine tumor.ConclusionOur study provides a detailed view of the characteristics, medical utilization states, and survival rates of patients newly diagnosed with primary spine tumors in Korea.

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“…Primary spinal cord tumors are considered rare, accounting for only 4–8% of all primary central nervous system (CNS) lesions 5,6,8,14 . To date, there have been no large population based epidemiological studies analyzing incidence patterns over time for this tumor type.…”

Section: Introductionmentioning

confidence: 99%

Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study

Hsu

Quattrone

Ostrom

et al. 2011

SPI

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Object Primary malignant spinal glioma represents a significant clinical challenge due to the devastating effect on clinical outcomes in the majority of cases. As they are infrequently encountered in any one center, there has been limited population-based data analysis on the incidence patterns of these aggressive tumors. The objective of this study was to use publically available Surveillance, Epidemiology and End Results (SEER) program data to examine the overall incidence and incidence patterns over time with regard to age at diagnosis, sex, race, primary site of tumor, and histological subtype in patients in whom primary malignant spinal cord gliomas were diagnosed between 1973 and 2006. Methods The study population of interest was limited to primary, malignant, pathologically confirmed spinal cord gliomas based on data drawn from the SEER 9 standard registries for patients diagnosed between 1973 and 2006. Variables of interest included age at diagnosis, sex, race, primary site of tumor, and histological subtype of tumor. The SEER*Stat 6.5.2 program was used to calculate frequencies, age-adjusted incidence rates with 95% CIs, and annual percentage change (APC) statistics with a 2-sided p value. In addition, linear correlation coefficients (R2) were calculated for the time association stratified by variables of interest. Results The overall age-adjusted incidence rate for primary malignant spinal gliomas was 0.12 per 100,000, which increased significantly over the study period (APC = 1.74; p = 0.0004; R2 = 0.36). The incidence was highest in patients diagnosed at ages 35–49 (0.17 per 100,000), males (0.14 per 100,000), whites (0.13 per 100,000), and those with ependymomas (0.07 per 100,000). Over the study period, the incidence of ependymomas increased significantly (APC = 3.17; p < 0.0001; R2 = 0.58) as did the incidence of these tumors in whites (APC = 2.13; p = 0.0001) and for both males (APC = 1.90, p value < 0.0001) and females (APC = 1.60, p < 0.0001). The authors found no significant changes in the incidence over time by age of diagnosis. Conclusions This study demonstrates an increasing overall incidence of primary, malignant spinal cord glioma over the past 3 decades. Notably, for ependymoma the incidence has increased, whereas the incidence of most other glioma subtypes remained stable. This may be due to improved diagnostic and surgical techniques, changes in histological classification criteria, and changes in neuropathology diagnostic criteria. Although primary, malignant spinal cord gliomas are rare, an improved understanding of the incidence will assist investigators and clinicians in planning potential studies and preparing for allocation of resources to care for these challenging patients.

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Incidence of Central Nervous System Tumors in Gironde, France

Cited by 76 publications

References 23 publications

Primary spinal cord tumors: review of 678 surgically treated patients in Japan. A multicenter study

Primary spinal cord tumors: review of 678 surgically treated patients in Japan. A multicenter study

A Nation-Wide Epidemiological Study of Newly Diagnosed Primary Spine Tumor in the Adult Korean Population, 2009-2011

Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study

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