Incidence of cavernoma development in children after radiotherapy for brain tumors

Burn, Sasha; Gunny, Roxana; Phipps, Kim; Gaze, Mark; Hayward, Richard

doi:10.3171/ped.2007.106.5.379

Cited by 60 publications

(100 citation statements)

References 15 publications

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“…mas following radiotherapy are believed to result from injury to vascular structures because radiotherapy stimulates the upregulation of angiogenesis factors such as vascular endothelial growth factor and basic fibroblast growth factor. Stimulation of such growth factors normally found in cavernomas may explain increased cavernoma formation following radiotherapy 6,7 . A peripheral rim of hemosiderin surrounding a reticulated core of heterogeneous signal intensity are typical MRI features of cavernomas:because of the high sensitivity of SWI to blood products cavernomas may appear only as black dots and their central components may be overwhelmed by susceptibility effects and may not be visible.…”

Section: Resultsmentioning

confidence: 99%

“…In our study none of the hypointense foci had the characteristic appearance of cavernomas but as explained above, we cannot exclude them. Studies have shown that many lesions that do not fulfill the diagnostic criteria for cavernomas on initial images do so in follow-up imaging 7 . In our eight follow-up patient, the nature of the black dots remained unchanged and thus we cannot confirm or exclude if they were cavernomas.…”

Section: Resultsmentioning

confidence: 99%

“…Different studies report that radiation can induce formation of cavernomas and that this occurs at a significantly higher rate when patients are irradiated as children 4,6,7 . Caverno-could represent metastases or lead to a search of other possible causes that may result in changes in management.…”

Section: Discussionmentioning

confidence: 99%

“…Common delayed effects of irradiation include diffuse white matter necrosis, focal or diffuse demyelination, reactive astrocytosis, brain atrophy, dystrophic mineralization, and radiation-induced vasculopathy 2 . Smallvessel injury is a prominent feature of delayed injury and different studies have shown that radiation can induce formation of capillary telangiectasias and cavernomas as a manifestation of vascular injury [3][4][5][6][7][8] . These vascular malformations could conceivably be confused with hemorrhagic metastases and their potential to bleed is unknown.…”

Section: Introductionmentioning

confidence: 99%

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Brain Radiation-Related Black Dots on Susceptibility-Weighted Imaging

et al. 2014

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brain Radiation-Related Black Dots on Susceptibility-Weighted Imaging

et al. 2014

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“…Cavernomas may cause seizures or other neurological defi cits, but mainly remain asymptomatic (Burn et al 2007 ).…”

Section: Tmargarida@gmailcommentioning

confidence: 99%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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