Incidence of Cardiovascular Disease in Individuals with Psoriasis: A Systematic Review and Meta-Analysis

Samarasekera, Eleanor; Neilson, Julie; Warren, Richard B; Parnham, Jill; Smith, Catherine

doi:10.1038/jid.2013.149

Cited by 252 publications

(226 citation statements)

References 34 publications

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“…Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle indeksi, alkol tüketimi ve kahve tüketimi açısından anlamlı farklılık yoktu. Medyan PAŞİ 10,0 (8,[3][4][5][6][7][8][9][10][11][12]8) idi. Sigara kullanan kişi oranı psoriazisli hastalarda anlamlı yüksekti.…”

Section: öZunclassified

“…It is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. Many studies conducted in recent years have shown that psoriatic patients, especially those with severe psoriasis, have increased risk of cardiovascular disease (CVD) and mortality associated with CVD [1][2][3] . The usual CVD risk factors, such as metabolic syndrome, smoking, and alcohol consumption that often accompany psoriasis, the lipid-(cyclosporin and acitretin) and homocysteineelevating (methotrexate) effects of the drugs used for treating psoriasis, and inflammation in the pathogenesis of psoriasis that show apparent parallelism with atherosclerosis are thought to contribute to this predisposition 4,5 .…”

Section: Introductionmentioning

confidence: 99%

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Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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ÖzBackground and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population Keywords: Psoriasis, homocysteine, folic acid Amaç: Homosistein kardiyovasküler hastalık, otoimmünite-enflamasyon ve DNA metilasyonu ile ilişkilendirilen sülfür içeren bir aminoasittir. Bu olgu-kontrol çalışmasında psoriazisli hastalarda plazma homosistein düzeylerinin ve homosisteini etkileyen folik asit, vitamin B6 ve vitamin B12 düzeylerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Polikliniğimizde takip edilen erişkin plak tip psoriazis hastaları ile yaş ve cinsiyet uyumlu kontrol grubunda alkol, kahve ve sigara tüketimi sorgulandı, katılımcıların boy ve ağırlıkları ölçüldü. Hastaların Psoriazis Alan Şiddet İndeksleri (PAŞİ) hesaplandı. Sabah açlık kan örnekleri alınarak homosistein, folik asit, vitamin B12, vitamin B6, kan şekeri, serum total kolesterol, trigliserid, yüksek yoğunluklu lipoproteinler (HDL), eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) değerleri çalışıldı. Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle inde...

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Section: öZunclassified

Section: Introductionmentioning

confidence: 99%

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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“…The release of inflammatory mediators by keratinocytes has several effects: the attraction of additional immune cells (e.g. macrophages, and neutrophils), the production of collagen and proteoglycans by fibroblasts, the activation and perpetuation of an inflammatory response, and the propagation of an adaptive immune response (11,65). Hence, the outcomes of stimulation of a small region of psoriasis-predisposed skin results in an immune reaction that can lead to the development of lesions at local and distant body sites, as well as systemic effects.…”

Section: Plaque Development and The Immune Response In Psoriasismentioning

confidence: 99%

“…Psoriasis has also been reported to be associated with metabolic disorders including obesity, non-alcoholic fatty liver disease (NAFLD), dyslipidaemia, and diabetes, as well as disorders that confer an unfavorable cardiovascular risk profile and higher mortality rates. These risks may be directly related to disease severity and duration, although the strength of the association varies across studies (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

Girolomoni

Griffiths

Krueger

et al. 2014

Journal of Dermatological Treatment

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Psoriasis is an immune-mediated inflammatory disease (IMID) which may have a major impact on a patient's life, especially when the disease is moderate to severe. There is evidence that treatment of psoriasis during the first years is conservative and frequently based on topical agents which rarely clear lesions. Treatment with systemic agents including biologics is often undertaken only when topical agents have proved unsuitable, even in patients with moderate to severe disease. However, there is evidence that in other IMIDs (rheumatoid arthritis and Crohn's disease), targeted systemic treatment given early in the treatment pathway may improve long-term patient outcomes. We hypothesize that a patient-centered therapeutic approach, undertaken early in the psoriasis treatment pathway (''early intervention'') with the goal of complete clearance, may improve control of cutaneous symptoms and may also modify disease course and burden. Critical points to address when designing an early intervention study would include: the definition of psoriasis disease activity; patient selection; intervention selection; and dosing strategies.

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“…Recent research suggests that patients with psoriasis have a systemic inflammatory state, putting them at increased risk of cardiovascular complications, including metabolic syndrome, peripheral vascular disease, stroke, myocardial infarction, and cardiac death. 3,4 Some articles suggest that tumor necrosis factor inhibitors may decrease the risk of stroke and myocardial infarction in patients with psoriasis. 5,6 As understanding of the disease has continued to evolve over five decades, research interests have expanded.…”

Section: Introductionmentioning

confidence: 99%

Trends in Type of Original Psoriasis Publications by Decade, 1960 to 2010

Sako

Famenini

2016

TPJ

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Context:Research investigating psoriasis has spanned decades, and as our understanding of the disease has evolved, the focus of publications has changed.Objective: We sought to characterize the trends in original psoriasis-related research from 1960 to 2010 chronologically by decade.Methods: A literature review was performed using the keyword psoriasis in the MED-LINE database. All original psoriasis-related articles published at the beginning of each decade were searched and categorized by study type and topic.Main Outcome Measure: Number of articles per topic.Results: A total of 869 original psoriasis-related articles were found. The number of publications increased 18 fold over 5 decades. The immunology and pathogenesis of psoriasis was the most frequently researched topic (36%), and retrospective studies were the most common study type (37%). Recent highly published topics included biologic therapy, genetics, and psoriasis-associated cardiovascular disease.Conclusion: Original psoriasis-related publications have grown substantially since 1960. Basic science research into the immunology and pathogenesis has been and continues to be the mainstay of psoriasis research. Recent research trends suggest the focus has expanded to topics such as psoriasis-associated cardiovascular disease, genetics, and biologic therapy. INTRODUCTIONPsoriasis is a chronic inflammatory skin condition affecting 2% of the population, and it can be physically and psychologically debilitating.1 Although psoriasis was first described in 1841, it was the 1960s that first saw a surge in psoriasis-related research. Initial studies focused on the keratinocyte, and nonmalignant proliferation and reduced differentiation were found to be hallmarks of psoriasis. Since then, considerable achievements have changed the way psoriasis is viewed. Advances in technology have allowed researchers to gain an understanding of the molecular mechanisms driving the disease. Breakthroughs in biologic therapy have revolutionized the way psoriasis is managed. Recent research suggests that patients with psoriasis have a systemic inflammatory state, putting them at increased risk of cardiovascular complications, including metabolic syndrome, peripheral vascular disease, stroke, myocardial infarction, and cardiac death.3,4 Some articles suggest that tumor necrosis factor inhibitors may decrease the risk of stroke and myocardial infarction in patients with psoriasis. 5,6 As understanding of the disease has continued to evolve over five decades, research interests have expanded. Our goal is to identify these new components to gain a better understanding of the current landscape and future direction of psoriasis-related research. On the basis of recent study findings, we hypothesized that there would be a higher proportion of recent publications investigating psoriasis-associated cardiovascular disease and biologic therapy. To our knowledge, no study has systematically examined research trends in this field. We sought to accomplish this through a literature rev...

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Incidence of Cardiovascular Disease in Individuals with Psoriasis: A Systematic Review and Meta-Analysis

Cited by 252 publications

References 34 publications

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

Trends in Type of Original Psoriasis Publications by Decade, 1960 to 2010

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