Incidence of carbapenem-resistant &lt;i&gt; Pseudomonas aeruginosa&lt;/i&gt; in diabetes and cancer patients

Varaiya, A; Kulkarni, M; Bhalekar, Pallavi; Dogra, J

doi:10.4103/0255-0857.42033

Cited by 11 publications

(8 citation statements)

References 7 publications

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“…In the current study, males were found to be more commonly affected (64%) with different infections caused by non-fermenters than females (36%) which is comparable to the findings of Varaiya et al who observed that 66.66% were males and 33.3% were females [14]. Nan-Yao Lee et al reported 67.4% were males and 32.6% were females [15].…”

Section: Discussionsupporting

confidence: 89%

Epidemiological Pattern of Non-Fermenting Metallo Beta Lactamase Producing Bacterial Pathogens Isolated From Clinical Specimens in a Tertiary Care Hospital in Kakinada

Vijayalakshmi¹

2017

J Bacteriol Mycol

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Background: Non-fermentative Gram negative bacilli are known causative pathogens responsible for hospital associated infection and for high morbidity and mortality rate across all genders and ages.Objectives: This study examined the prevalence of Non-Fermentative Gram Negative Bacilli Metallo Beta-Lactamase Isolates (NFGNB-MBL) among carbapenem-resistant strains from clinical specimens and the epidemiological pattern (Age, Sex and Source of infection). Methodology:A total of 250 clinical specimens from diverse infections were collected and analyzed, using standard microbiological methods. For MBL detection, two previously described methods were employed i.e. Imipenem-EDTA combined disc test and Imipenem-EDTA double disc synergy test (DDST).Results: Sixty (24%) NFGNB isolates were identified, highest number from hospital associated infections (93.33%). Pseudomonas aeruginosa accounted for n=40 (66.67%) followed by Acinetobacter baumannii n=10 (16.67%), Alcaligenes faecalis n=6 (10%) and Stenotrophomonas maltophilia n=4 (6.66%) respectively. The isolates showed high sensitivity to imipenem (91.67%) and the incidence of MBL producing non-fermenters among the imipenem resistant organisms was found to be 100%. Conclusion: The prevalence of MBL producing isolates and association with hospital infection is of clinical concern and the therapeutic option in treatment and management of patient.

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Section: Discussionsupporting

confidence: 89%

Epidemiological Pattern of Non-Fermenting Metallo Beta Lactamase Producing Bacterial Pathogens Isolated From Clinical Specimens in a Tertiary Care Hospital in Kakinada

Vijayalakshmi¹

2017

J Bacteriol Mycol

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“…In previous studies from other parts of the world, varying rates of resistance (4 to 70%) have been reported for imipenem and meropenem (Varaiya et al, 2008;Gonlugur et al, 2004;Sanchez-Romero et al, 2003;Gladstone et al, 2005).…”

Section: Discussionmentioning

confidence: 92%

Imipenem-resistant Psedomonas aeruginosa: Epidemiology and susceptibility patterns at a Teaching Hospital in Riyadh, Saudi Arabia

Otaibi¹,

Al-Hulaily²

2012

Afr. J. Microbiol. Res.

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Pseudomonas aeruginosa is an important nosocomial pathogen. It causes high morbidity and mortality. The incidence of imipenem-resistance is increasing among Gram negative bacilli, particularly P. aeruginosa, often associated with resistance to other antipseudomonal drugs. The aim of this study is to assess potential risk factors for nosocomial infections of imipenem-resitant P. aeruginosa (IRPA), and to obtain base line information on the epidemiology and susceptibility pattern of this important pathogen. In a retrospective study of patients with nosocomial P. aeruginosa infection from July 2008 to August 2010 in a tertiary care hospital in Riyadh, Saudi Arabia, the imipenem susceptibility of 381 nosocomial P. aeruginosa isolates was evaluated by disk diffusion method and confirmed by determining minimum inhibitory concentration (MIC) using E test. Antimicrobial susceptibility testing for other antibiotics was performed. The features of the patients with IRPA infections were compared to those with imipenem-sensitive P. aeruginosa (ISPA) infections. During the study period, IRPA was isolated from 60 (15.7%) of patients, and the ISPA was isolated from 321 (84.3%) patients. IRPA were most frequently isolated from urine (23.3%) cultures (p=0.01), whereas ISPA were most frequently isolated from swab (57.6%) cultures (p=0.04). Risk factors that were significantly associated with IRPA included: surgery (p=0.001), diabetes mellitus (p=0.04), and trauma (p=0.01). Overall, the highest P. aeruginosa rate (33%) was obtained in the medical ward followed by ICU (29%), surgical ward (28.3%), oncology (5.5%), burn unit (3%), and renal dialysis unit (2.4%). ICU patients accounted for 21(35%) of IRPA infected patients. All tested antipseudomonal agents, demonstrated higher resistance rates among IRPA isolates than ISPA isolates (p=0.001). Pipracillin/tazobactam was the most active agent for both groups followed by amikacin and ceftazidime. No significant difference in the mortality rate between the imipenem-resistant and susceptible groups. Isolates of P. aeruginosa that are resistant to all, or almost all, available antibiotics "panresistant" are now prevalent worldwide. Our study showed that imipenem-resistance in this clinical pathogen is an emerging problem. Periodical surveillance studies are therefore essential to determine the current susceptibility patterns of P. aeruginosa to different antimicrobial agents, and to identify risk factors for acquisition of carbapenem-resistant strains.

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“…2 There are both economic and scientific reasons for this slowdown in antibiotic development. 3 From the economic perspective, it is difficult for pharmaceutical companies to generate a substantial profit from antibiotics.…”

Section: Mohit Kumar Phdmentioning

confidence: 99%

Resistant Superbugs: Race against Time

Kumar

2016

Infect. Control Hosp. Epidemiol.

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Incidence of carbapenem-resistant <i> Pseudomonas aeruginosa</i> in diabetes and cancer patients

Cited by 11 publications

References 7 publications

Epidemiological Pattern of Non-Fermenting Metallo Beta Lactamase Producing Bacterial Pathogens Isolated From Clinical Specimens in a Tertiary Care Hospital in Kakinada

Epidemiological Pattern of Non-Fermenting Metallo Beta Lactamase Producing Bacterial Pathogens Isolated From Clinical Specimens in a Tertiary Care Hospital in Kakinada

Imipenem-resistant Psedomonas aeruginosa: Epidemiology and susceptibility patterns at a Teaching Hospital in Riyadh, Saudi Arabia

Resistant Superbugs: Race against Time

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