Incidence of cancer among patients with systemic sclerosis in Korea: results from a single centre

Ky, Kang; Hw, Yim; Ij, Kim; Ju, Yoon Hyun; Jh, Ju; Hy, Kim; Park, Sang Hoon

doi:10.1080/03009740802642062

Cited by 49 publications

(44 citation statements)

References 17 publications

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“…Some studies reported no significant increased risk (19)(20)(21), similar to our results, while other studies indicated an excess incidence of malignancy with significantly increased SIRs (22)(23)(24)(25)(26)(27)(28)(29)(30). In SSc patients with long disease duration, it is not rare to develop a malignancy with or without carcinogenic effect of SSc itself or the medication, such as cyclophosphamide.…”

Section: Discussionsupporting

confidence: 89%

“…In this study, the histopathological type of lung cancer was characterized as predominant adenocarcinoma (including bronchioloalveolar carcinoma), which has often been reported to be the most frequent type (24,27,29,34). Similarly, adenocarcinoma was the most common type in nonSSc Japanese patients with ILD (36), as well as in the Japanese general population, especially in females (41).…”

Section: Discussionmentioning

confidence: 90%

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Incidence and the Risk Factor of Malignancy in Japanese Patients with Systemic Sclerosis

et al. 2012

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 90%

Incidence and the Risk Factor of Malignancy in Japanese Patients with Systemic Sclerosis

et al. 2012

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“…While the data are controversial, some studies have suggested that the risk of cancer may be higher in patients with diffuse cutaneous disease (4). Similarly, interstitial lung disease may be a risk factor for lung cancer in scleroderma (1, 14, 15). Patients developing new onset scleroderma at an older age also have an elevated risk of cancer (see details below) (1, 16, 17).…”

Section: Scleroderma Patients Have An Elevated Risk Of Many Types Of mentioning

confidence: 99%

Cancer and scleroderma

Shah

Casciola‐Rosen

2015

Current Opinion in Rheumatology

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Purpose of review Recent data suggest a paraneoplastic mechanism of scleroderma pathogenesis in unique subsets of scleroderma patients. In this article, we review these data, explore potential links between cancer and scleroderma, and propose an approach to malignancy screening in scleroderma. Recent findings Emerging data have demonstrated that patients with scleroderma and RNA polymerase III autoantibodies have a significantly increased risk of cancer within a few years of scleroderma onset. Genetic alterations in the gene encoding RNA polymerase III (POLR3A) have been identified, and patients with somatic mutations in POLR3A have evidence of mutation specific T cell immune responses with generation of cross-reactive RNA polymerase III autoantibodies. These data strongly suggest that scleroderma is a by-product of anti-tumor immune responses in some patients. Additional epidemiologic data demonstrate that patients developing scleroderma at older ages may also have a short cancer-scleroderma interval, suggestive of paraneoplastic disease. Summary Scleroderma may be a paraneoplastic disease in unique patient subsets. Aggressive malignancy screening in these patients may aid in early cancer detection. Further study is required to determine whether cancer therapy could improve scleroderma outcomes in this patient population.

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“…The majority of patients with scleroderma who develop lung cancer have underlying interstitial lung fibrosis, are female and the most frequent tumors are adenocarcinoma or of the bronchioloalveolar cell type [169] , not necessarily associated with cigarette smoking [163] . The average interval time between the onset of these two diseases appears to be more than 5 years [163,[170][171][172] . It is believed that the chronic inflammation and repair that occur in SS-ILD results in recurrent cellular injury and genetic damage to local epithelial cells, predisposing to the development of cancer through sequential cellular morphological alterations [173] .…”

Section: Ss and Lung Cancermentioning

confidence: 99%

Investigation of Lung Involvement in Connective Tissue Disorders

Papiris¹,

Manali²,

Kolilekas³

et al. 2015

Respiration

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Lung involvement in connective tissue disorders (CTDs) may present as pleomorphic since any lung compartment may be involved such as airways, exocrine secretory and alveolar epithelia, interstitial lung structure, pulmonary vasculature and pleura as well as, in specific disorders, several tissues of the thoracoabdominal ventilator pump. Any combination of the above anatomic structures may be involved concomitantly although some specific combinations may include a determinant of rheumatic disorders. The diagnosis of a specific CTD requires the fulfilment of clearly defined clinical and laboratory criteria including in most cases positivity for autoantibodies, mostly specific serologic combinations. In this setting, serologic investigation targets mainly, although not exclusively, the detection of antinuclear antibodies. A specific serologic positivity or a combination of autoantibodies constitutes not only a diagnostic criterion for a specific CTD, but may also characterize the pattern of respiratory manifestation in a determinant rheumatic disorder. Therefore, the investigation of lung involvement in CTDs requires adequate skills in the ambit of a multidisciplinary approach and an extended spectrum of diagnostic tools and modalities able to detect both early clinical clues and serologic conversion as well as any pathophysiologic alteration that regards the complexity of respiratory functional status. Although many patients with CTDs suffer from a ‘vicious' combination of lung involvement, lung drug toxicity and infections related to the above two as well as to the ‘mater' disease, for space reasons this review will focus on the established lung manifestations that regard the 7 major CTDs.

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Incidence of cancer among patients with systemic sclerosis in Korea: results from a single centre

Abstract: The SIR of cancer was significantly higher in SSc patients, and especially in those who were male, than in the general population. Lung cancer was the most common cancer. Active surveillance for the detection of cancer should be performed in all SSc patients.

Cited by 49 publications

References 17 publications

Incidence and the Risk Factor of Malignancy in Japanese Patients with Systemic Sclerosis

Incidence and the Risk Factor of Malignancy in Japanese Patients with Systemic Sclerosis

Cancer and scleroderma

Investigation of Lung Involvement in Connective Tissue Disorders

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