Incidence of Cancer among Michigan Nurse-anesthetists

Corbett, Thomas H.; Cornell, Richard G.; Lieding, Keith G.; Endres, Judy L.

doi:10.1097/00000542-197303000-00010

Cited by 127 publications

(33 citation statements)

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“…In another large American study, in which morbidity was followed in a questionnaire survey of 73,496 persons, it was found that women, but not men, exposed to anesthetic gases had a higher frequency of cancer, especially leukemia and lymphoma (16). In other American studies (19,20) the incidence of malignant diseases among 525 anesthetic nurses was followed. Excluding skin cancer, a higher incidence of unusual tumors, such as malignant lymphoma, leiomyosarcoma, hepatocellular carcinoma, and cancer of the pancreas, was found.…”

Section: Epidemiologymentioning

confidence: 99%

Anesthetic gases as an occupational hazard--a review.

Edling¹

1980

Scand J Work Environ Health

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Section: Epidemiologymentioning

confidence: 99%

Anesthetic gases as an occupational hazard--a review.

Edling¹

1980

Scand J Work Environ Health

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“…Female anesthetists and operating room nurses (4,66,69,81,124), laboratory technicians (83,139), female employees in a copper smelter (113,114), and the wives of vinyl chloride polymerization workers ,(66) are suggested to have an increased risk of abortion. (83) and Strandberg et al (139) International Agency for Research on Cancer (70), Knill-Jones et al (81) and Rosenberg & Kirves (124) Infante et al (66) (+) (7,72) - (143) + (1M, 1(7) + (72) + (27,70) + (70,73) + (4,26) ± (108,151) ± (108) + ( …”

Section: Epidemiologic Monitoringmentioning

confidence: 99%

Genetic risks caused by occupational chemicals. Use of experimental methods and occupational risk group monitoring in the detection of environmental chemicals causing mutations, cancer and malformations.

Hemminki¹,

Sorsa²,

Vainio³

1979

Scand J Work Environ Health

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“…Neurotoxic [32], hepatotoxic [22], nephrotoxic [24,32] and carcinogenic effects [13,32,39], as well as fertility alterations, increased incidence of spontaneous abortions and congenital abnormalities have been observed in these professionals [3,24,41,45,46]. Nevertheless, there is still some controversy regarding the genotoxic and/or mutagenic effects of acute or chronic exposure to anesthetic gases [14,25,27], even though significant increases in the frequency of chromosome aberrations and of micronuclei (MN) in peripheral blood lymphocytes of professionals exposed to such agents have been reported [8,11,12,29,31,35,42,44].…”

Section: Introductionmentioning

confidence: 99%

Genotoxic effects of anesthetics in operating room personnel evaluated by micronucleus test

Araujo¹,

Silva-Grecco²,

Bisinotto³

et al. 2013

J Anesthesiol Clin Sci

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Exposure to certain chemical agents causes damage to the genetic material. There is controversy about the genotoxic and/or mutagenic effect caused by acute or chronic anesthetics exposure. The aim of this research was to assess and compare the frequency of micronuclei (MN) in professionals working in operating rooms and other hospital areas. The genotoxic and cytotoxic effects were evaluated in lymphocytes using the micronucleus test and the proliferative index, respectively. We examined peripheral blood lymphocyte cultures from 30 operating room professionals (exposed group) and 30 professionals non-exposed in other hospital areas of the same hospital (control group). There was no statistically significant difference in proliferative index between the groups. Nevertheless, there was an increase in MN frequency in binucleated (BN) cells in the exposed group (p=0.0003) compared to the control group. Moreover, there was a statistically significant difference between genders (p=0.0187), and the frequency of MN in BN cells from women was higher than in men. Therefore, gender influenced the frequency of MN. The age and period of working time in an operating room influenced the MN frequency only in women professionals. Thereby, there was a genotoxic effect in occupationally exposed professionals, and the micronucleus test could be used in the biomonitoring of human populations for evaluating the risk of developing cancer.

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Incidence of Cancer among Michigan Nurse-anesthetists

Cited by 127 publications

References 0 publications

Anesthetic gases as an occupational hazard--a review.

Anesthetic gases as an occupational hazard--a review.

Genetic risks caused by occupational chemicals. Use of experimental methods and occupational risk group monitoring in the detection of environmental chemicals causing mutations, cancer and malformations.

Genotoxic effects of anesthetics in operating room personnel evaluated by micronucleus test

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