Incidence of cancer after kidney transplant: results from the North Italy transplant program

Abstract

These preliminary data underline the importance of long-term surveillance of transplant recipients, choice of immunosuppressive treatment, and careful donor selection.

Risk of Kaposi's sarcoma and of other cancers in Italian renal transplant patients

“…Of these, 1340 received their transplants at Niguarda Hospital, Milan, between 1972and 504 at Policlinico Gemelli Hospital, Rome, between 1970. As with other investigations, we excluded patients who survived less than 10 days after transplant, those with a pretransplant history of cancer, or who developed cancer in the 30-day period after transplantation (Adami et al, 2003;Pedotti et al, 2003). Nonmelanoma skin cancers were not evaluated since information on basal cell carcinoma was not recorded and that on squamous cell carcinoma might not have been complete.…”

“…For nonmelanoma skin cancers and lip cancer, the relative risks are increased 10-to 60-fold (Kinlen et al, 1979;Birkeland et al, 1995;Adami et al, 2003), while the excess of non-Hodgkin's lymphoma (NHL) is about five-to 10-fold (Hoshida et al, 1997;Birkeland et al, 2000;Adami et al, 2003). Kaposi's sarcoma (KS) has been frequently reported in transplant patients in the United States (Penn, 2000), in the Middle East (Qunibi et al, 1988) and in Italy (Montagnino et al, 1996;Pedotti et al, 2003), but the excess risk has not been closely quantified. No increased risk of KS has been reported in transplant patients from the Nordic countries (Birkeland et al, 1995(Birkeland et al, , 2000Adami et al, 2003), or Japan (Hoshida et al, 1997).…”

Incidence and Clinical Behavior of Papillary Thyroid Carcinoma in Renal Allograft Recipients: A Single Center Experience

“…20, 21 It is evident that malignancies, such as lymphoma and Kaposi's sarcoma, are more common in renal transplant recipients than the general population. Nevertheless, it remains unclear whether other carcinomas also develop more frequently in renal transplant recipients.…”

Untitled

“…Pedotti and associates reported that the 10-year survival in kidney recipients without cancer is 92.8% and with cancer is 56.6%. 3 In the 58 patients who developed skin cancer, there was 50% mortality from cancer. 6 Overall 5-year survival after the diagnosis of the tumor was 81% and 40% for patients with 1 malignant tumor and patients with more than 1 malignant tumor, respectively, in this study.…”

“…Compared with the general population, certain tumors occur more frequently in renal transplant recipients and are associated with poor prognosis. 2,3 Immunosuppressive treatment, in addition to common risk factors, is thought to play a major role in the development of malignancy. 4 Our aim in this study was to evaluate the incidence of posttransplant malignancy and investigate the clinical and histopathologic features of these patients.…”