Incidence of cancer after asthma development: 2 independent population-based cohort studies

Woo, Annie; Lee, Seung Won; Koh, Hyun Yong; Kim, Mi Ae; Han, Man Yong; Yon, Dong Keon

doi:10.1016/j.jaci.2020.04.041

Cited by 74 publications

(100 citation statements)

References 47 publications

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“…South Korea has a nationwide health system covering 98% of the population; medical conditions based on ICD codes in this database have been reported in previous studies. 9 During the ongoing COVID-19 pandemic, the South Korean Government has provided complimentary and mandatory health services and insurance to all South Korean patients with COVID-19. We obtained data from National COVID-19 related registers , which included all patients who underwent laboratory SARS-CoV-2 tests in South Korea through services facilitated by the Korea Centers for Disease Control and Prevention (KCDC), the Health Insurance Review and Assessment Service of Korea, and the Ministry of Health and Welfare, South Korea, including COVID-19-related outcomes and death records.…”

Section: Methodsmentioning

confidence: 99%

Association between mental illness and COVID-19 susceptibility and clinical outcomes in South Korea: a nationwide cohort study

Lee

Yang

Moon

et al. 2020

The Lancet Psychiatry

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220

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Background Evidence for the associations between mental illness and the likelihood of a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and the clinical outcomes of COVID-19 is scarce. We aimed to investigate these associations with data from a national register in South Korea. Methods A nationwide cohort study with propensity score matching was done in South Korea using data collected from the Health Insurance Review and Assessment Service of Korea. We defined mental illness as present if one of the relevant ICD-10 codes was recorded at least twice within 1 year for an outpatient or inpatient. Severe mental illness was considered as non-affective or affective disorders with psychotic features. We included all patients aged older than 20 years who were tested for SARS-CoV-2 through services facilitated by the Korea Centers for Disease Control and Prevention, the Health Insurance Review and Assessment Service of Korea, and the Ministry of Health and Welfare, South Korea. We investigated the primary outcome (SARS-CoV-2 test positivity) in the entire cohort and the secondary outcomes (severe clinical outcomes of COVID-19: death, admission to the intensive care unit, or invasive ventilation) among those who tested positive. Findings Between Jan 1 and May 15, 2020, 216 418 people were tested for SARS-CoV-2, of whom 7160 (3·3%) tested positive. In the entire cohort with propensity score matching, 1391 (3·0%) of 47 058 patients without a mental illness tested positive for SARS-CoV-2, compared with 1383 (2·9%) of 48 058 with a mental illness (adjusted odds ratio [OR] 1·00, 95% CI 0·93–1·08). Among the patients who tested positive for SARS-CoV-2, after propensity score matching, 109 (8·3%) of 1320 patients without a mental illness had severe clinical outcomes of COVID-19 compared with 128 (9·7%) of 1320 with a mental illness (adjusted OR 1·27, 95% CI 1·01–1·66). Interpretation Diagnosis of a mental illness was not associated with increased likelihood of testing positive for SARS-CoV-2. Patients with a severe mental illness had a slightly higher risk for severe clinical outcomes of COVID-19 than patients without a history of mental illness. Clinicians treating patients with COVID-19 should be aware of the risk associated with pre-existing mental illness. Funding National Research Foundation of Korea.

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Section: Methodsmentioning

confidence: 99%

Association between mental illness and COVID-19 susceptibility and clinical outcomes in South Korea: a nationwide cohort study

Lee

Yang

Moon

et al. 2020

The Lancet Psychiatry

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220

236

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“…25 The Charlson comorbidity index score was calculated from the ICD-10 codes by methods that were reported previously. 26 The use of systemic glucocorticoids within 180 days preceding cohort entry was also investigated and recorded. 27 The region of residence was classified as rural (ie, Gyeonggi, Gangwon, Gyeongsangbuk, Gyeongsangnam, Chungcheongbuk, Chungcheongnam, Jeollabuk, Jeollanam, and Jeju) or urban (eg, Seoul, Sejong, Busan, Incheon, Daegu, Gwangju, Daejeon, and Ulsan).…”

Section: Study Populationmentioning

confidence: 99%

“…Allergic asthma was defined as asthma with at least 1 additional allergic disorder (allergic rhinitis or atopic dermatitis), whereas nonallergic asthma was defined as asthma without any atopic disorder. 26…”

Section: Exposurementioning

confidence: 99%

“…The adequacy of matching was confirmed by comparing propensity score densities (see Figs E1-E12 in this article's Online Repository at www.jacionline.org) and standardized mean differences (SMD). 26 Data were analyzed by using binary logistic regression or analysis of covariance models. The estimation of the adjusted odds ratios (aORs) with 95% CIs or the adjusted mean difference (with 95% CIs) was performed after adjusting for the following potential confounders to reduce the possibility of bias: age; sex; region of residence (urban or rural); history of diabetes mellitus, cardiovascular disease, cerebrovascular disease, COPD, hypertension, and chronic kidney disease; the Charlson comorbidity index (0, 1, and > _2); previous use of systemic glucocorticoids and immunosuppressants; and allergic disorders (as relevant).…”

Section: Analysis Overviewmentioning

confidence: 99%

“…To compensate for this issue, we adjusted the patient's history of COPD, a wellknown smoking-related disease. 26,39 Fourth, because of the urgent global situation, the COVID-19-related data provided by the Korean government involve short-term data (<3.5 years) of the patient's history for quick claim processing. More clinical studies involving longer follow-up data are required to provide more information and to validate the association between allergic diseases and COVID-19.…”

Section: Sars-cov-2 Test Positivity and Allergic Diseasesmentioning

confidence: 99%

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Allergic disorders and susceptibility to and severity of COVID-19: A nationwide cohort study

Yang

Koh

Moon

et al. 2020

Journal of Allergy and Clinical Immunology

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246

270

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Background: There is inconclusive and controversial evidence of the association between allergic diseases and the risk of adverse clinical outcomes of coronavirus disease 2019 (COVID-19). Objective: We sought to determine the association of allergic disorders with the likelihood of a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and with clinical outcomes of COVID-19 (admission to intensive care unit, administration of invasive ventilation, and death). Methods: A propensity-score-matched nationwide cohort study was performed in South Korea. Data obtained from the Health Insurance Review & Assessment Service of Korea from all adult patients (age, >20 years) who were tested for SARS-CoV-2 in South Korea between January 1, 2020, and May 15, 2020, were analyzed. The association of SARS-CoV-2 test positivity and allergic diseases in the entire cohort (n 5 219,959) and the difference in clinical outcomes of COVID-19 were evaluated in patients with allergic diseases and SARS-CoV-2 positivity (n 5 7,340). Results: In the entire cohort, patients who underwent SARS-CoV-2 testing were evaluated to ascertain whether asthma and allergic rhinitis were associated with an increased likelihood of SARS-CoV-2 test positivity. After propensity score matching, we found that asthma and allergic rhinitis were associated with worse clinical outcomes of COVID-19 in patients with SARS-CoV-2 test positivity. Patients with nonallergic asthma had a greater risk of SARS-CoV-2 test positivity and worse clinical outcomes of COVID-19 than patients with allergic asthma. Conclusions: In a Korean nationwide cohort, allergic rhinitis and asthma, especially nonallergic asthma, confers a greater risk of susceptibility to SARS-CoV-2 infection and severe clinical outcomes of COVID-19.

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Cancer incidence after asthma diagnosis: Evidence from a large clinical research network in the United States

et al. 2023

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Incidence of cancer after asthma development: 2 independent population-based cohort studies

Cited by 74 publications

References 47 publications

Association between mental illness and COVID-19 susceptibility and clinical outcomes in South Korea: a nationwide cohort study

Association between mental illness and COVID-19 susceptibility and clinical outcomes in South Korea: a nationwide cohort study

Allergic disorders and susceptibility to and severity of COVID-19: A nationwide cohort study

Cancer incidence after asthma diagnosis: Evidence from a large clinical research network in the United States

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