Incidence of brain metastases as a first site of recurrence among women with triple receptor-negative breast cancer.

Xin, Lei; Dawood, Shaheenah; Litton, Jennifer K.; Buchholz, Thomas A.; Hortobágyi, Gabriel N.; González-Angulo, Ana M.

doi:10.1200/jco.2011.29.15_suppl.1039

Cited by 1 publication

(1 citation statement)

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“…Brain metastases (BM) have an estimated prevalence of around 9% and occur more frequently in individuals with advancedstage disease [1]. Additionally, patients with stage III triple receptor-negative breast cancer have a notably higher risk of developing BM as a first site of recurrence, which is associated with poor survival [2]. BM are associated with significant morbidity and mortality, and their treatment is challenged by the blood-brain barrier and the unique microenvironment of the central nervous system [3].…”

Section: Introductionmentioning

confidence: 99%

Impact of Clinical Examination and Gamma Knife Surgery in Stage IV Breast Cancer With Brain Metastasis

Shanbhag,

Tom,

Duncan

et al. 2024

Cureus

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Metastatic breast cancer often presents with significant diagnostic and treatment challenges. This case report highlights the crucial role of thorough clinical examination and history-taking in diagnosing and managing a patient with metastatic breast cancer, mainly focusing on the successful integration of Gamma Knife radiosurgery (GKRS). We present a case of a 68-year-old postmenopausal woman with metastatic breast cancer, initially presenting with a primary tumour in the left breast and later developing a solitary brain metastasis (BM) in the left temporal lobe. Following neoadjuvant chemotherapy and left mastectomy, the patient experienced involuntary movements in the right arm, leading to the discovery of the brain lesion. Critical to this diagnosis was a detailed clinical examination emphasising the importance of vigilant monitoring in cancer management. The patient underwent GKRS, offering a focused and less invasive treatment approach with favourable outcomes. This case underscores the value of clinical vigilance in managing complex breast cancer cases. The integration of GKRS as a targeted treatment modality for BM represents a pivotal aspect of modern oncological care, especially for patients with multiple treatment modalities. This report emphasizes the importance of clinical examination in the early detection of complications such as BM in breast cancer patients. Furthermore, it demonstrates the effectiveness of GKRS in managing such metastases, reinforcing its role as a valuable tool in the multidisciplinary treatment approach for advanced breast cancer.

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Section: Introductionmentioning

confidence: 99%

Impact of Clinical Examination and Gamma Knife Surgery in Stage IV Breast Cancer With Brain Metastasis

Shanbhag,

Tom,

Duncan

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

Incidence of brain metastases as a first site of recurrence among women with triple receptor-negative breast cancer.

Abstract: Background-The aim of this retrospective study was to define the incidence of brain metastases as a first site of recurrence among women with triple receptor-negative breast cancer (TNBC).

Cited by 1 publication

References 28 publications

Impact of Clinical Examination and Gamma Knife Surgery in Stage IV Breast Cancer With Brain Metastasis

Impact of Clinical Examination and Gamma Knife Surgery in Stage IV Breast Cancer With Brain Metastasis

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