Incidence of atrial fibrillation in conjunction with breast cancer

D’Souza, Maria; Smedegaard, Lærke; Madelaire, Christian; Nielsen, Dorte; Torp‐Pedersen, Christian; Gislason, Gunnar; Schou, Morten; Fosbøl, Emil Loldrup

doi:10.1016/j.hrthm.2018.10.017

Cited by 21 publications

(21 citation statements)

References 20 publications

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“…to controls, diagnosed at fewer than 90 days from the cancer diagnoses (11), we did not find such an association in our patient population. While a retrospective study by D'Souza et al suggested a higher incidence of AF in female patients with breast cancer (26), we found no difference in the prevalence of AF in breast cancer patients in a separate gender-based analysis. Our results are similar to those from a large Danish cohort study by Vinter et al who found no association between breast cancer and AF (4).…”

Section: Atrial Fibrillation and Type Of Cancercontrasting

confidence: 97%

Cancer Radiation Therapy May Be Associated With Atrial Fibrillation

Apte

Dherange

Mustafa

et al. 2021

Front. Cardiovasc. Med.

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Background: The association of atrial fibrillation (AF) with cancer and cancer types is inconclusive. Similarly, data regarding the association of AF with different cancer therapies are controversial.Objectives: To study the association of AF with cancer subtypes and cancer therapies.Methods: We studied all patients aged 18–89 years who presented to the Feist Weiller Cancer Center, with or without a diagnosis of cancer, between January 2011 and February 2016. Electronic health records were systematically queried for baseline demographics and ICD-9 and ICD-10 codes for specific co-morbidities. Patients with a diagnosis of AF were tabulated based on cross-validation with the ECG database and/or by recorded history. We assessed the prevalence and risk of AF based on cancer diagnosis, specific cancer type, and cancer therapy.Results: A total of 14,600 patients were analyzed. Compared to non-cancer patients (n = 6,801), cancer patients (n = 7,799) had a significantly higher prevalence of AF (4.3 vs. 3.1%; p < 0.001). However, following correction for covariates in a multivariable logistic regression model, malignancy was not found to be an independent risk factor for AF (p = 0.32). While patients with solid tumors had a numerically higher prevalence of AF than those with hematological malignancies (4.3 vs. 4.1%), tumor type was not independently associated with AF (p = 0.13). AF prevalence was higher in patients receiving chemotherapy (4.1%), radiation therapy (5.1%), or both (6.9%) when compared to patients not receiving any therapy (3.6%, p = 0.01). On multivariable logistic regression, radiation therapy remained an independent risk factor for AF for the entire study population (p = 0.03) as well as for the cancer population (p < 0.01).Conclusions: Radiation therapy for cancer is an independent risk factor for AF. The known association between cancer and AF may be mediated, at least in part, by the effects of radiation therapy.

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Section: Atrial Fibrillation and Type Of Cancercontrasting

confidence: 97%

Cancer Radiation Therapy May Be Associated With Atrial Fibrillation

Apte

Dherange

Mustafa

et al. 2021

Front. Cardiovasc. Med.

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“…10 A cohort study from Northern Israel reported an increased AF risk in the 90 days after breast cancer diagnosis, but not thereafter. 15 D’Souza et al 25 reported an increased AF rate among Danish patients with EBC from 6 months to 3 years, with an increased rate in the first 6 months only among patients younger than 60 years.…”

Section: Discussionmentioning

confidence: 99%

Association of Early-Stage Breast Cancer and Subsequent Chemotherapy With Risk of Atrial Fibrillation

et al. 2019

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“…Risk for developing AF after cancer diagnosis was highest in the first 90 days. Another nationwide study of patients with breast cancer showed an increased risk for AF among patients with breast cancer who were <60 years of age compared with the general population ( 57 ). Conversely, there is some evidence that AF itself may portend an increased risk for cancer diagnosis ( 58 , 59 ).…”

Section: Common Mechanistic Links Between Cancer and Afmentioning

confidence: 99%

Common Pathophysiology in Cancer, Atrial Fibrillation, Atherosclerosis, and Thrombosis

Leiva

AbdelHameid

Connors

et al. 2021

JACC: CardioOncology

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Cardiovascular disease and cancer are the 2 leading causes of death worldwide. Emerging evidence suggests common mechanisms between cancer and cardiovascular disease, including atrial fibrillation and atherosclerosis. With advances in cancer therapies, screening, and diagnostics, cancer-specific survival and outcomes have improved. This increase in survival has led to the coincidence of cardiovascular disease, including atrial fibrillation and atherosclerosis, as patients with cancer live longer. Additionally, cancer and cardiovascular disease share several risk factors and underlying pathophysiologic mechanisms, including inflammation, cancer-related factors including treatment effects, and alterations in platelet function. Patients with cancer are at increased risk for bleeding and thrombosis compared with the general population. Although optimal antithrombotic therapy, including agent choice and duration, has been extensively studied in the general population, this area remains understudied in patients with cancer despite their altered thrombotic and bleeding risk. Future investigation, including incorporation of cancer-specific characteristics to traditional thrombotic and bleeding risk scores, clinical trials in the cancer population, and the development of novel antithrombotic and anti-inflammatory strategies on the basis of shared pathophysiologic mechanisms, is warranted to improve outcomes in this patient population.

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Incidence of atrial fibrillation in conjunction with breast cancer

Cited by 21 publications

References 20 publications

Cancer Radiation Therapy May Be Associated With Atrial Fibrillation

Cancer Radiation Therapy May Be Associated With Atrial Fibrillation

Association of Early-Stage Breast Cancer and Subsequent Chemotherapy With Risk of Atrial Fibrillation

Common Pathophysiology in Cancer, Atrial Fibrillation, Atherosclerosis, and Thrombosis

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