Incidence of and risk factors for bile duct stones after living donor liver transplantation: An analysis of 100 patients

Senoo, Takemasa; Ichikawa, Tatsuki; Taura, Naota; Miyaaki, Hisamitsu; Miuma, Satoshi; Shibata, Hidetaka; Honda, Takeshi; Takatsuki, Mitsuhisa; Hidaka, Masaaki; Soyama, Akihiko; Eguchi, Susumu; Nakao, Kazuwa

doi:10.1111/hepr.12438

Cited by 3 publications

(2 citation statements)

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“…This study indicated that bile leaks and bile stones comprise 82.4% of biliary complications following LT 11 . One study found that the incidence of bile duct stones following LDLT was 10%, while another reported an incidence range of 1.8%‐18% 12,13 …”

Section: Discussionmentioning

confidence: 92%

Percutaneous removal of biliary stones post‐liver transplant in a pediatric patient: Case report and review of the literature

Rohringer

Hannick

Lorenzo

et al. 2020

Pediatric Transplantation

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This is a case of a girl born with citrullinemia diagnosed in her firstweek of life after presenting with hyperammonemia and encephalopathy. At 1 year of age, she received a deceased donor segmental split left LT due to recurrent and refractory metabolic decompensations despite optimal medical and dietary management. During the initial LT, a duct-to-duct anastomosis was performed. One week later, the patient required a revision of the biliary anastomosis due to a bile leak and subphrenic abscess. During revision, the end-toend anastomosis was taken down, and a bilio-enteric anastomosis was created using a Roux-en-Y hepatojejunostomy. A surgical drain remained in place for 1 month, after which a cholangiogram revealed stenosis of the anastomosis with a biliary stricture. The biliary drain AbstractThis case report describes an 8-year-old girl who underwent a segmental LT for a primary diagnosis of citrullinemia at the age of 12 months. She presented with cholangitis secondary to stenosis of the biliary-enteric anastomosis. MRI revealed dilatation of intrahepatic bile ducts associated with multiple stones. An endoscopic approach failed to decompress the bile ducts and remove the stones. A percutaneous approach was then undertaken. After placement of a temporary external biliary drain for 12 days, a 26 French sheath was placed to access the bile ducts. Using a 14Fr flexible cystoscope, 80%-90% of the biliary stones were removed. This was followed by antegrade balloon dilatation of the biliary-enteric anastomosis. Two months later, the procedure was repeated, resulting in complete clearance of the biliary stones. An internal-external biliary drain was maintained in placed for 10 months. The patient has been asymptomatic, with no evidence of stone recurrence for 13 months after drain removal. Percutaneous biliary stone removal is commonly performed in adults with non-transplanted livers, especially in complex cases, and has also been shown to be successful in the pediatric population. However, it is rarely reported in transplanted livers in adults, and to the best of our knowledge, no pediatric cases have been reported. This case illustrates that this technique can be successfully utilized in pediatric LT patients. K E Y W O R D S biliary complications, biliary stones, citrullinemia, liver transplantation, pediatric liver transplant, percutaneous stone removal How to cite this article: Rohringer TJ, Hannick JH, Lorenzo A, Avitzur Y, Temple M, Parra DA. Percutaneous removal of biliary stones post-liver transplant in a pediatric patient: Case report and review of the literature. Pediatr Transplant.

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Section: Discussionmentioning

confidence: 92%

Percutaneous removal of biliary stones post‐liver transplant in a pediatric patient: Case report and review of the literature

Rohringer

Hannick

Lorenzo

et al. 2020

Pediatric Transplantation

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“…The incidence of bile duct stones after LT is 10% 35 and more than half of these patients experience biliary strictures. An FCSEMS is placed with a balloon or basket after the removal of common bile duct stones, however, since intrahepatic stones are located proximally to the stricture, they are difficult to remove.…”

Section: Discussionmentioning

confidence: 99%

Fully covered metallic stents for anastomotic biliary strictures after living donor liver transplantation

et al. 2023

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Objectives Anastomotic biliary strictures (ABSs) are common complications following living donor liver transplantation (LDLT). We evaluated the feasibility of a novel removable, intraductal, fully covered, self‐expandable metallic stent (FCSEMS) for the treatment of ABSs following LDLT. Methods Nine patients with duct‐to‐duct ABSs that developed following LDLT were prospectively enrolled in this study. We placed a short FCSEMS with a long lasso and middle waist formation in each patient's ABS above the papilla and removed it 16 weeks later. Results The FCSEMS placements were successful in all nine cases. Four patients experienced mild cholangitis, which was resolved with conservative treatment. Additionally, there was one case of distal migration. The FCSEMSs were successfully removed from all the patients, and the clinical success rate was 100%. Stricture recurrence occurred in one (11.1%) patient during the follow‐up period. Limitations The small number and lack of comparison with other types of FCSEMSs and plastic stents. Conclusions Intraductal placement of FCSEMSs is useful for treating refractory ABSs after LDLT, although further studies are required with larger sample sizes.

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Biliary Stones After Brain Dead Liver Transplantation Today: Rates, Risk Factors, Treatments, and Outcomes

Maggi

Chierici

Bianchi

et al. 2019

Transplantation Proceedings

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Incidence of and risk factors for bile duct stones after living donor liver transplantation: An analysis of 100 patients

Abstract: In the present study, right lobe graft and bile duct strictures are independent risk factors for BDS formation after LDLT. More careful observation and monitoring are required in the patients with high-risk factors.

Cited by 3 publications

References 29 publications

Percutaneous removal of biliary stones post‐liver transplant in a pediatric patient: Case report and review of the literature

Percutaneous removal of biliary stones post‐liver transplant in a pediatric patient: Case report and review of the literature

Fully covered metallic stents for anastomotic biliary strictures after living donor liver transplantation

Biliary Stones After Brain Dead Liver Transplantation Today: Rates, Risk Factors, Treatments, and Outcomes

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