Incidence of and risk factors for development of oral mucositis in outpatients undergoing cancer chemotherapy

Çakmak, Seher; Nural, Nesrın

doi:10.1111/ijn.12710

Cited by 39 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some conclusions were also provided by this present study. The median (IQR) of survival days of our patients was 9 days (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), and the mean (SD) was 10.85 (7.44). The average survival times were shorter than those in other countries [5,10].…”

Section: Discussionmentioning

confidence: 88%

“…The second section was the oral examination, which was used to gather oral health data on mucosa health, oral cleanliness, moisture, and oral function. To evaluate oral mucositis, we used the mucositis classification of World Health Organization (WHO) [12][13][14]. In this study, we divided the patients into two groups based on the presence or absence of mucositis: the presence of mucositis (grades I-IV) and absence of mucositis (Grade 0).…”

Section: Oral Examination and Data Recordingmentioning

confidence: 99%

See 1 more Smart Citation

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: improvement of oral conditions

Liu

et al. 2020

BMC Palliat Care

View full text Add to dashboard Cite

Background In end-of-life patients with advanced cancers, oral examination, oral care, and oral re-examination are crucial. Although oral symptoms are among the major complaints of end-of-life patients, few studies have focused on oral care in these patients. In this study, the association between oral symptoms and oral dryness among end-of-life patients was examined, and improvement of oral conditions after oral care interventions by a professional dentist was quantified. Methods This prospective intervention study included 27 terminally ill patients with advanced cancers in a hospice ward. Professional oral care was administered every morning, and the improvement of oral conditions was assessed by comparing oral conditions before and after the intervention. Oral assessment was performed using the Oral Health Assessment Tool (OHAT) and Oral Assessment Guide. Oral dryness was evaluated through Clinical Diagnosis Classification of oral dryness and an oral moisture device. Oral cleanliness was evaluated using a bacterial counter, and tongue smears were collected for Candida examination; furthermore, oral function was recorded. Results The presence of oral mucositis was closely associated with severe oral dryness (odds ratio [OR] = 14.93; 95% confidence interval [CI]: 1.95–114.38). The level of oral debris retention was significantly related to the degree of oral dryness (OR = 15.97; 95% CI: 2.06–123.72). The group with higher scores (OHAT > 8), which represent poor oral conditions, showed severe oral dryness (OR = 17.97; 95% CI: 1.45–223.46). Total OHAT scores (median: 7 vs 2) and those of other subgroups (lip, tongue, gums and tissues, saliva, and oral cleanliness showed a significant decrease after the intervention. Furthermore, the occurrence of mucositis (47.1% vs 0%), candidiasis rate (68.8% vs 43.8%), oral dryness self-sensation (63.6% vs 9.1%), and severe oral debris (52.9% vs 11.8%) decreased significantly. Conclusions Proper oral care can improve oral health and hygiene, reduce the rate of mucositis, reduce the sensation of oral dryness, increase oral moisture, and reduce the chances of oral infections among end-of-life patients. Daily oral care is necessary and can alleviate oral discomfort, increase food intake, and increase the chances of communication between end-of-life patients and their families.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Oral Examination and Data Recordingmentioning

confidence: 99%

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: improvement of oral conditions

Liu

et al. 2020

BMC Palliat Care

View full text Add to dashboard Cite

show abstract

“…The WHO and the National Cancer Institute (NCI) mucositis grading scales were utilized to assess the OM severity. In both scales, four grades of OM are included (stage 0 = lack of ulcers, stage 1 = pain and erythema, stage 2 = erythema and ulcer, stage 3 = ulcer and large erythema and the patient cannot eat solid food, and stage 4 = mucositis is in severe stage and oral feeding is not possible) [25].…”

Section: Methodsmentioning

confidence: 99%

Nigella sativa Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia

Hussain

Ameen

Mohammed

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Objective The present study aims at evaluating the beneficial effect of Nigella sativa (NS) oil mouth rinse in the management of chemotherapy- (CT-) induced oral mucositis (OM) in patients with acute myeloid leukemia (AML). Methods Fifty-four AML patients were participated in this study and randomly allocated to either the test group or a control group. The patients of the test group received NS oil mouth rinse during 28-day CT, while the participants of the control group received a “magic mouthwash” formula. The primary outcome of this study was the incidence and severity of CT-induced OM in terms of erythema and ulcer. The secondary outcomes were the pain severity score, swallowing function, and the salivary concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Results NS oil mouth rinse attenuated the progression of CT-induced OM compared with the control formula (AUC = 5.9 vs. 38.4, P < 0.05) and significantly decreased the erythema and ulceration scores (AUC of total OMAS = 11.4 vs. 85.9, P < 0.001) compared with the magic mouthwash formula. It also reduced the pain score and enabled all the participants of this group to consume normal food during treatment. It significantly decreased salivary IL-6 (AUC = 7376 vs. 16599, P < 0.001), while the changes of TNF-α levels were not significant (AUC = 676.9 vs. 885.2, P > 0.05). Conclusions NS oil mouth rinse is effective in attenuating the severity of CT-induced OM and improves the pain and swallowing function in AML patients.

show abstract

“…The second section was the oral examination, which was used to gather oral health data on mucosa health, oral cleanliness, moisture, and oral function. To evaluate oral mucositis, we used the mucositis classi cation of World Health Organization (WHO) [12][13][14]. In this study, we divided the patients into two groups based on the presence or absence of mucositis: the presence of mucositis (grades I-IV) and absence of mucositis (Grade 0).…”

Section: Oral Examination and Data Recordingmentioning

confidence: 99%

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: Improvement of oral conditions

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: In end-of-life patients with advanced cancers, oral examination, oral care, and oral re-examination are crucial. Although oral symptoms are among the major complaints of end-of-life patients, few studies have focused on oral care in these patients. In this study, the association between oral symptoms and oral dryness among end-of-life patients was examined, and improvement of oral conditions after oral care interventions by a professional dentist was quantified.Methods: This prospective intervention study included 27 terminally ill patients with advanced cancers in a hospice ward. Professional oral care was administered every morning, and the improvement of oral conditions was assessed by comparing oral conditions before and after the intervention. Oral assessment was performed using the Oral Health Assessment Tool (OHAT) and Oral Assessment Guide. Oral dryness was evaluated through Clinical Diagnosis Classification of oral dryness and an oral moisture device. Oral cleanliness was evaluated using a bacterial counter, and tongue smears were collected for Candida examination; furthermore, oral function was recorded.Results: The presence of oral mucositis was closely associated with severe oral dryness (odds ratio [OR] = 14.93; 95% confidence interval [CI]: 1.95–114.38). The level of oral debris retention was significantly related to the degree of oral dryness (OR = 15.97; 95% CI: 2.06–123.72). The group with higher scores (OHAT > 8), which represent poor oral conditions, showed severe oral dryness (OR = 17.97; 95% CI: 1.45–223.46). Total OHAT scores (median: 7 vs 2) and those of other subgroups (lip, tongue, gums and tissues, saliva, and oral cleanliness showed a significant decrease after the intervention. Furthermore, the occurrence of mucositis (47.1% vs 0%), candidiasis rate (68.8% vs 43.8%), oral dryness self-sensation (63.6% vs 9.1%), and severe oral debris (52.9% vs 11.8%) decreased significantly.Conclusions: Proper oral care can improve oral health and hygiene, reduce the rate of mucositis, reduce the sensation of oral dryness, increase oral moisture, and reduce the chances of oral infections among end-of-life patients. Daily oral care is necessary and can alleviate oral discomfort, increase food intake, and increase the chances of communication between end-of-life patients and their families.

show abstract

Incidence of and risk factors for development of oral mucositis in outpatients undergoing cancer chemotherapy

Cited by 39 publications

References 30 publications

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: improvement of oral conditions

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: improvement of oral conditions

Nigella sativa Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: Improvement of oral conditions

Contact Info

Product

Resources

About