Incidence of and potential risk factors for gallstone disease in a general population sample

Halldestam, Ingvar; Kullman, Eric; Borch, Kurt

doi:10.1002/bjs.6687

Cited by 76 publications

(61 citation statements)

References 41 publications

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“…As for gender, our results are consistent with the generally accepted view that gallstone prevalence is higher in women than in men [32,33]. Quite a few studies revealed a positive correlation between a high serum LDL level and cholesterol gallstone development [34,35]; the results of our study displayed a relationship between a high serum LDL level and GD prevalence, though we failed to get the information of the gallstone type. However, some reports have showed that there is no relation between serum LDL level and the presence of gallstones [36,37].…”

Section: Discussionsupporting

confidence: 82%

Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis

Zhang

Chen²,

Chen³

et al. 2016

Digestion

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Aim: To elucidate the prevalence and risk factors of gallstone disease (GD) among patients with liver disease and explore their association with the aetiology and severity of hepatic injury. Methods: We analysed 4,832 subjects of hepatic injury induced by one of the following aetiologies: hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, excessive alcohol consumption. The risk factors significantly associated with GD were analysed using stepwise logistic regression analysis, the influence of aetiology and severity of liver disease on the prevalence of GD were assessed by multiple logistic regression analysis adjusting for confounding factors. Results: Three thousand forty eight patients were of positive HBV surface antigen alone with a prevalence of GD of 18.6%, 526 were tested as positive Anti-HCV alone with a prevalence of GD of 22.4%, and 1,258 were identified with excessive alcohol consumption patterns with a prevalence of GD of 13.5%. In each aetiological category, the prevalence of GD increased by age. Stepwise logistic regression analysis showed that age, female, low-density lipoprotein-cholesterol (LDL-Cho), family history of GD, HBV infection, HCV infection, chronic hepatitis and cirrhosis were independent associated with HCV-related cirrhosis in both genders, HBV-related cirrhosis in males and alcohol-related cirrhosis in females compared with patients with less severe liver disease. After adjusting for gender, age, LDL-Cho and family history of GD, patients with HCV-related cirrhosis (OR 2.66, 95% CI 1.49-3.84) but not HBV-related cirrhosis (OR 1.52, 95% CI 0.73-1.82) were more likely to have GD compared with alcohol-related cirrhosis. Conclusion: HCV infection is positively associated with gallstone formation especially in those with cirrhosis patients.

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Section: Discussionsupporting

confidence: 82%

Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis

Zhang

Chen²,

Chen³

et al. 2016

Digestion

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“…The natural course of GSD is typically benign; however, its complications contribute substantially to healthcare costs and may even be life threatening [15]. A crucial benefit of early detection for GSD is that ultrasonography can detect asymptomatic cases, enabling appropriate treatment and prevention of serious influences such as acute gallstone pancreatitis or gallbladder cancer [16,17].…”

Section: Clinical Implications Of Gallstone Disease Screeningmentioning

confidence: 99%

Evidence-Based Medicine for Gallstone Disease Screening: An Experience at Cheng-Hsin General Hospital, Taipei, Taiwan

Tung¹

2014

GHOA

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“…Among them, 1-3% become symptomatic and seek medical treatment. The gold standard treatment of cholelithiasis is gallbladder surgical removal, which is one of the most commonly performed surgical procedures worldwide [3,4,5]. Open surgical removal of the gallbladder was performed as a gold standard procedure for treatment in the period before 1988.…”

Section: Introductionmentioning

confidence: 99%

Enriched view of postcholecystectomy syndrome: Nowadays and in former times

et al. 2015

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Aim-Background:The aim of the present review is to evidence the differences in the nature of PCS between open and laparoscopic cholecystectomy and also to examine how this condition has evolved over the years. In 5 to 40% of patients with cholelithiasis, regardless of the type of surgery, the symptoms persist postoperatively, leading to the development of the so-called postcholecystectomy syndrome (PCS). The time of the onset of symptoms ranges from 2 days to 25 years after cholecystectomy.Methods: A total number of 926 articles were found as a literature reference pool. We searched English language articles published in Medline, Scopus and google scholar. Only review articles were retrieved because no comparative studies or prospective clinical trials were found to provide statistically significant conclusions. The final group of articles was reviewed, and a total of 57 papers were used for the present review. Results:The literature is conflicting as concerns the pathophysiology and the aetiology of PCS. Regardless of the type of surgery, it seems that PCS is correlated to age and sex. The prevailing view is that retained or recurrent gallstones, gallbladder remnants and Sphincter of Oddi dysfunction are the primary causes. Moreover, systemic diseases of the gastrointestinal (GI) tract, cardiac disorders, autoimmune diseases, nervous system and psychological distress can mimic PCS symptoms. Nonetheless, there are many available techniques regarding diagnosis and treatment. Nowadays, the majority of researchers endorse ERCP as the gold standard for diagnosis and treatment. Conclusion:The preoperative meticulous investigation of patients with cholelithiasis is mandatory in order to identify coexisting disorders related to PCS, achieve a better therapeutic approach, and principally reduce PCS incidence.

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Incidence of and potential risk factors for gallstone disease in a general population sample

Abstract: The incidence of gallstones in this population was 1.39 per 100 person-years. Gallstone development was related to length of follow-up and LDL-cholesterol levels, and inversely related to alcohol consumption.

Cited by 76 publications

References 41 publications

Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis

Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis

Evidence-Based Medicine for Gallstone Disease Screening: An Experience at Cheng-Hsin General Hospital, Taipei, Taiwan

Enriched view of postcholecystectomy syndrome: Nowadays and in former times

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