Incidence of Adipose Tissue Alterations in First-Line Antiretroviral Therapy

Galli, Massimo; Cozzi‐Lepri, Alessandro; Ridolfo, Aana Lisa; Gervasoni, Cristina; Ravasio, Laura; Corsico, Laura; Gianelli, Erika; Vaccarezza, Mauro; Vullo, Vincenzo; Cargnel, Antonietta; Minoli, Lorenzo; Coronado, O.; Giacometti, Andrea; Antinori, Andrea; Antonucci, Giorgio; Monforte, A d’Arminio; Moroni, Mauro

doi:10.1001/archinte.162.22.2621

Cited by 70 publications

(65 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most published reports assessed fat changes using a participant's report of change, confirmed on examination by a health care provider. 2,4,6,[10][11][12][13]15,20,25,[27][28][29][30] Studies have also used different definitions to define fat changes in HIV. Some defined fat changes as occurring in either peripheral or central body sites, [2][3][4]10,16,25,31 some combined both peripheral and central fat changes into 1 syndrome, [11][12][13]18,20,22,27,28 and others reported separately on lipoatrophy only, lipohypertrophy only, and "combined" syndromes.…”

mentioning

confidence: 99%

“…Some defined fat changes as occurring in either peripheral or central body sites, [2][3][4]10,16,25,31 some combined both peripheral and central fat changes into 1 syndrome, [11][12][13]18,20,22,27,28 and others reported separately on lipoatrophy only, lipohypertrophy only, and "combined" syndromes. 15,17,21,23,24,29,30 Most studies used unidirectional questionnaires that presumed the presence of anticipated findings of peripheral lipoatrophy and central lipohypertrophy. 6,11,12,15,17,21,23,24,[27][28][29][30]32 Thus, there remains a debate about the definition of the syndrome.…”

mentioning

confidence: 99%

“…15,17,21,23,24,29,30 Most studies used unidirectional questionnaires that presumed the presence of anticipated findings of peripheral lipoatrophy and central lipohypertrophy. 6,11,12,15,17,21,23,24,[27][28][29][30]32 Thus, there remains a debate about the definition of the syndrome. 1,15,17,20,24,29,30,[32][33][34] Early studies also did not include an HIV-uninfected comparison group.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Fat Distribution in Women With HIV Infection

2006

JAIDS Journal of Acquired Immune Deficiency Syndromes

113

View full text Add to dashboard Cite

Objective-Both peripheral fat loss and central fat gain have been reported in women with HIV infection. We determined the fat changes that are specific to HIV infection in women.Methods-HIV-infected and control women from the study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM) were compared. Lipoatrophy or lipohypertrophy was defined as concordance between participant report of fat change and clinical examination. Whole-body magnetic resonance imaging measured regional adipose tissue volumes. The relationship among different adipose tissue depots was assessed. Factors associated with individual depots were analyzed using multivariate linear regression.Results-HIV-infected women reported more fat loss than controls in all peripheral and most central depots. Peripheral lipoatrophy was more frequent in HIV-infected women than controls (28% vs. 4%, P < 0.001), whereas central lipohypertrophy was similar (62% vs. 63%). Among HIV-infected women, those with central lipohypertrophy were less likely to have peripheral lipoatrophy (odds ratio, 0.39; 95% confidence interval, 0.20 to 0.75, P = 0.006) than those without central lipohypertrophy. On magnetic resonance imaging, HIV-infected women with clinical peripheral lipoatrophy had less subcutaneous adipose tissue (SAT) in peripheral and central sites and less visceral adipose tissue (VAT) than HIV-infected women without peripheral lipoatrophy. Compared with controls, HIV-infected women had less SAT in the legs, regardless of the presence or absence of lipoatrophy. However, those without lipoatrophy had more VAT and upper trunk SAT than controls. Use of the antiretroviral drug stavudine was associated with less leg SAT but was not associated with VAT. The use of highly active antiretroviral therapy, however, was associated with more VAT.Conclusions-Peripheral lipoatrophy occurs commonly in HIV-infected women but is not associated with reciprocally increased VAT or trunk fat.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Fat Distribution in Women With HIV Infection

2006

JAIDS Journal of Acquired Immune Deficiency Syndromes

113

View full text Add to dashboard Cite

show abstract

“…A presença da síndrome lipodistrófica em HIV foi relatada em um estudo italiano, numa prevalência de 19% em grupo de pacientes que iniciou seu primeiro esquema de HAART, seguido durante 18 meses (154) . Na Espanha, a prevalência foi de 28% (155) .…”

Section: Perfil Dos Portadores Do Hiv Segundo Lipodistrofia Autorrefeunclassified

“…De acordo com Jaime et al (29) , (29,83,154) . Tal informação também coincide com os resultados desta pesquisa.…”

Section: Imc<19 E O Estudo Do Nhanes -National Health and Nutrition Eunclassified

Perfil antropométrico e distribuição da gordura corpórea relacionados ao risco cardiovascular em adultos vivendo com HIV/AIDS

Soares¹

View full text Add to dashboard Cite

Metabolic and Skeletal Complications of HIV Infection

Morse¹,

Kovacs²

2006

JAMA

105

View full text Add to dashboard Cite

Over the past 10 years, in conjunction with the broad availability of potent antiretroviral regimens, the care of human immunodeficiency virus (HIV)-infected patients has shifted from prevention and treatment of opportunistic infections and malignancies to management of the metabolic and related complications associated with HIV infection and its treatment. Metabolic disorders, including lipodystrophy, dyslipidemia, and insulin resistance, occur at a high rate in HIV-infected individuals receiving highly active antiretroviral therapy (HAART). These disorders are associated with increased risk of cardiovascular disease and have become an important cause of morbidity and mortality in HIV-infected patients. Herein, we present the case of a patient with HIV infection who responded well to HAART but developed multiple complications potentially related to this therapy. This article reviews the clinical characteristics of the metabolic and skeletal disturbances observed in HIV infection and discusses strategies for their management.

show abstract

Incidence of Adipose Tissue Alterations in First-Line Antiretroviral Therapy

Abstract: Different types of ATAs might derive from distinct pathways and multifactorial causes. Adipose tissue alterations are a frequent and relatively early finding during first-line antiretroviral therapy.

Cited by 70 publications

References 16 publications

Fat Distribution in Women With HIV Infection

Fat Distribution in Women With HIV Infection

Perfil antropométrico e distribuição da gordura corpórea relacionados ao risco cardiovascular em adultos vivendo com HIV/AIDS

Metabolic and Skeletal Complications of HIV Infection

Contact Info

Product

Resources

About