Incidence of adenomyosis uteri in a Greek population

Chrysostomou, M.; Akalestos, G.; Kallistros, S.; Papadimitriou, V.; Nazar, S.; Chronis, G.

doi:10.3109/00016349109007157

Cited by 13 publications

(6 citation statements)

References 14 publications

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“…Histology, depth of MI, tumor grade, presence of LVSI, positive peritoneal cytology, tumor size and LNS have been universally recognized as prognostic factors for determining long-term clinical course of the disease (25,26). Although certain studies have evaluated the association between AM and the clinical course of EEC, the mechanism by which AM interferes with tumoral progression remains unresolved (9,12,27,28).…”

Section: Discussionmentioning

confidence: 99%

Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation

et al. 2015

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Abstract.The aim of the current study was to diagnose the concomitant presence of adenomyosis (AM) in endometrioid endometrial cancer (EEC) in order to evaluate its value as an oncological prognostic marker. A retrospective analysis of 289 patients diagnosed with EEC who underwent total hysterectomy, bilateral salpingo-oophorectomy and pelvic-lymphadenectomy was conducted. The total cohort included 37 patients in Group A (those with concomitant AM and EEC) and 252 patients in Group B (those affected only by EEC). The following factors were evaluated: Presence or absence of AM, tumor grade, depth of myometrial invasion, tumor size, lymphovascular space involvement, lymph node status, peritoneal cytology, concomitant detection of endometrial atypical-hyperplasia or polypoid endometrial features and tumor stage according to the International Federation of Gynecology and Obstetrics (FIGO) classification. Uterine examination of different sections of uterine cervix, corpus, myomas and cervical or endometrial polyps was performed. The diagnosis of AM was confirmed when the distance between the lower border of the endometrium and the foci of the endometrial glands and stroma was >2.5 mm. Parametric and nonparametric statistical tests were performed when possible; continuous variables were analyzed using a Student's t-test, and categorical variables were analyzed by the χ 2 test or Fisher's exact test. The association between FIGO stage and group was determined to be significant: 83.8% of Group A patients were categorized as FIGO stage I, vs. 68.7% of Group B patients. In addition, Group A was associated with lower grades in FIGO stage, myometrial invasion, lymphovascular space involvement, lymph node involvement and tumor size. The findings suggest that the intraoperative evaluation of the presence of AM in patients with EEC may aid surgeons in estimating oncological risk and in selecting the most appropriate surgical treatment.

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Section: Discussionmentioning

confidence: 99%

Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation

et al. 2015

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“…The reported prevalence of adenomyosis among women who undergo hysterectomy has varied from 8% to 28% in studies conducted in Greece, Italy, Denmark, and the United States, and has been reported to be as high as 57% in Pakistan. (Bergholt, Eriksen, Berendt, Jacobsen, & Hertz, 2001; Chrysostomou et al, 1991; Curtis, Hillis, Marchbanks, & Peterson, 2002; McCausland, 1992; Parazzini et al, 1997; Shaikh & Khan, 1990; Vavilis et al, 1997; Vercellini et al, 1995; Vercellini et al, 2006) Variability in these estimates is partially due to differences in histological criteria used for diagnosis and may also be related to differences in the relative frequency of comorbidities that necessitate hysterectomy in different populations. (Bergholt et al, 2001)…”

Section: Introductionmentioning

confidence: 99%

A Case-Control Investigation of Adenomyosis: Impact of Control Group Selection on Risk Factor Strength

Trabert

Weiss

Rudra

et al. 2011

Women's Health Issues

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Objective-Using a medical-record abstraction-based case-control study with two control groups, we evaluated adenomyosis risk factors and investigated differences related to comparison group selection.Materials and Methods-Medical records of all female 18-49 year old Group Health (GH) enrollees with ICD-9 code 617.0 were abstracted using a standard data collection form. Cases were enrollees diagnosed with adenomyosis (N=174) between April 1996 and September 2001. For comparison, medical records of two control groups were selected from the GH population: an age-matched sample of female enrollees (population-based controls N=149) and all female 18-49 year-old enrollees undergoing a hysterectomy (hysterectomy controls N=106) during the same time without adenomyosis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression, adjusted for identified covariates.Results-Compared with normal and underweight women, overweight and obese women had increased adenomyosis risk using hysterectomy controls [OR (95% CI): 2.2 (1.0, 4.5) overweight; 2.2 (1.1, 4.3) obesity] and population controls [OR (95% CI): 2.1 (1.2, 4.0) overweight; 3.8 (2.0, 7.0) obesity]. Using population controls, women with at least one live birth were more likely to have adenomyosis than nulliparous women [OR (95% CI): 3.4 (1.9, 6.2)].Conclusion-While some risk factors persisted in analyses using either control group, divergent results in relation to other risk factors for adenomyosis suggest that results of investigations of this disease may be affected by the choice of the comparison population.

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“…In hysterectomy specimens the incidence of adenomyosis reported in the literature varies, ranging from a high of 61.5% to a low of 8.8% (2,5,(11)(12)(13)(14)(15). Hyperestrogenemia, a cause of endometrial hyperplasia and fibroid growth, has been associated with adenomyosis, (5,11) as has prior pregnancy (2,3,13,15,16).…”

Section: Introductionmentioning

confidence: 99%

“…When present, these symptoms lead to a presumptive preoperative diagnosis of adenomyosis, and are often used as an indication for hysterectomy. While some have suggested that adenomyosis is associated with these symptoms (1)(2)(3)(4)(5)(20)(21)(22) and more commonly coexists with fibroids (2) and endometriosis (2,(17)(18)(19) others have concluded the opposite view (3,(11)(12)(13)(14)(15)(16). It is apparent that these issues need further clarification.…”

Section: Introductionmentioning

confidence: 99%

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Adenomyosis a variant, not a disease? Evidence from hysterectomized menopausal women in the Study of Women's Health Across the Nation (SWAN)

Weiss

Maseelall

Schott

et al. 2009

Fertility and Sterility

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Objective-Our study evaluates the symptoms commonly attributed to adenomyosis in women undergoing the menopausal transition. We hypothesized that adenomyosis is more commonly seen in women with fibroids, pelvic pain, abnormal uterine bleeding, and in the presence of endometriosis. Design-Retrospective cohortSetting-multi-site community based study Patients-SWAN study enrollees who had hysterectomies Interventions-None Main Outcome Measurements-Relationship of Adenomyosis to other entitiesResults-Adenomyosis was found in 48% of 137 patients. Frequencies of presenting symptoms were similar in those with and without evidence of adenomyosis. The same prevalence of fibroids, 37 % versus 43% (p=0.39), endometriosis, 3% versus 5% (p=0.41), abnormal bleeding, 27% versus 33% (p=0.72), or chronic pelvic pain in the presence of fibroids 12% versus 17%, (p=0.58), was seen in the presence or absence of adenomyosis.Conclusions-Adenomyosis is a common diagnosis seen in hysterectomized specimens from women undergoing the perimenopausal transition. Adenomyosis is equally common in women who also have fibroids, endometriosis, pelvic pain, or abnormal uterine bleeding, and those women that do not. Therefore, adenomyosis is an incidental finding, not the source of the symptomatology. It appears not to be a "disease" per se, but a normal variant.

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Incidence of adenomyosis uteri in a Greek population

Cited by 13 publications

References 14 publications

Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation

Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation

A Case-Control Investigation of Adenomyosis: Impact of Control Group Selection on Risk Factor Strength

Adenomyosis a variant, not a disease? Evidence from hysterectomized menopausal women in the Study of Women's Health Across the Nation (SWAN)

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