Incidence of acute pulmonary embolism among patients hospitalized with COVID-19: a systematic review and meta-analysis

Muneer, Mohamed S.; Ritchie, Charles; Elkhidir, Ibrahim; Mohammadat, Doaa T.; Ahmed, Hussein J.; Altayeb, Khalid A.; Yassin, Rawan; Hassan, Riyan M.; Hamad, Saada A.; Nimir, Mohammed; Hamid, Osman S.; Johnson, Margaret M.; Narula, Tathagat; Erben, Young; Tawk, Rabih G.; Miller, David A.; Gupta, Vivek; Devcic, Zlatko; Freeman, William D.; Toskich, Beau B.

doi:10.12688/f1000research.27425.1

Cited by 1 publication

(1 citation statement)

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“…15,17,18 However, some recent large metaanalyses reported a pooled incidence of PE of 14,7 to 17,6% of COVID-19-patient developing PE, which is quite higher than in precedent studies. 12,[19][20][21] In our cohort, only 19.44% (84/432) underwent a CTPA. Therefore, underdiagnosed PE may assume that there were in the silent PE population, relatively asymptomatic or severe patients to undergo CTPA.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of D-Dimers for Predicting Pulmonary Embolism in COVID-19-Patients

Brem

Asmae

Amane

et al. 2021

Clin Appl Thromb Hemost

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Importance Proinflammatory and hypercoagulable states with marked elevation seen in D-Dimer levels have been accurately described in patients infected by the SARS- Cov2 even without pulmonary embolism (PE). Objectives To compare D-dimers values in patients infected by the novel Coronavirus 2019 (COVID-19) with and without PE and to establish an optimal D-dimer cut-off to predict the occurrence of PE, which guides pulmonary computed tomography angiography (CTPA) indication. Methods We retrospectively enrolled all COVID-19-patients admitted between October first and November 22th, 2020, at the University Hospital Center of Mohammed VI, Oujda (Morocco), suspected to have PE and underwent a CTPA. Demographic characteristics and blood test results were compared between PE-positive and PE-negative. The receiver operating characteristics (ROC) curve was constructed to establish an optimal D-Dimer cut-off to predict the occurrence of PE. Results The study population consisted of 84 confirmed COVID-19-patients. The mean age was 64.93 years (SD 14.19). PE was diagnosed on CTPA in 31 (36.9%) patients. Clinical symptoms and in-hospital outcomes were similar in both groups except that more men had PE ( p = .025). The median value of D-dimers in the group of patients with PE was significantly higher (14 680[IQR 33620-3450]ng/mL compared to the group of patients without PE 2980[IQR 6870-1600]ng/mL [P < .001]. A D-dimer at 2600 ng/mL was the optimal cut-off for predicting PE with a sensitivity of 90.3%, and AUC was .773[CI 95%, .667 −.876). Conclusion A D-dimer cut-off value of 2600 ng/mL is a significant predictor of PE in COVID-19-patients with a sensitivity of 90.3%.

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