Incidence of acute peripheral neurotoxicity after deep regional hyperthermia of the pelvis

Wielheesen, D. H. M.; Haveman, J.; Fatehi, Daryoush; Rhoon, Gerard C. van; Zee, Jacoba van der

doi:10.1080/02656730701881125

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…4,5 Despite the complementary nature of hyperthermia- and IR-induced cell killing, the precise mechanism of heat-induced cell death is not yet clear, and the synergistic interaction between heat and IR in cell killing is even less well understood. Because phase III clinical trials have shown significant benefits from adding hyperthermia to radiotherapy regimens for a number of malignancies, 6,7 understanding the mechanisms involved in heat-mediated IR sensitization has become clinically important. This review will focus on the possible role of hyperthermia in DNA damage response and transcriptional regulation of heat shock proteins in the context of enhancing the potential of targeted radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Molecular Parameters of Hyperthermia for Radiosensitization

Pandita¹,

Pandita²,

Bhaumik

2009

Crit Rev Eukar Gene Expr

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Hyperthermia is a potent sensitizer of cell killing by ionizing radiation (IR), however, the precise mechanism of heat-induced cell death is not yet clear. Radiosensitization can be attributed to the fact that heat is a pleiotropic damaging agent, affecting multiple cell components to varying degrees by altering protein structures, thus influencing the DNA damage response. Hyperthermia alone induces several steps associated with IR signaling in cells. For example, hyperthermia enhances ATM kinase activity and increases cellular ATM autophosphorylation. This prior activation of ATM or other components of the IR-induced signaling pathway by heat interferes with the normal IR-induced signaling required for chromosomal DNA double-strand break repair, thus resulting in increased cell killing post irradiation. Hyperthermia also induces heat shock protein 70 (HSP70) synthesis and enhances telomerase activity. HSP70 expression is associated with radioresistance. Inactivation of HSP70 and telomerase increases residual DNA DSBs post IR exposure, which correlates with increased cell killing, supporting the role of HSP70 and telomerase in IR-induced DNA damage repair. Thus, hyperthermia influences several molecular parameters involved in sensitizing tumor cells to radiation and can enhance the potential of targeted radiotherapy.

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Section: Introductionmentioning

confidence: 99%

Molecular Parameters of Hyperthermia for Radiosensitization

Pandita¹,

Pandita²,

Bhaumik

2009

Crit Rev Eukar Gene Expr

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“…The development of neurotoxicity was more frequent in the mEHT Group however cisplatin was a perfect predictor of neurotoxicity in the multivariate regression analysis and was therefore the most likely cause of the development of neurotoxicity. Although peripheral neuropathy is a known but rare side effect of HT to the pelvis [5,17] and we therefore cannot exclude the potential effects of deep heating on the development of peripheral neuropathy related to increased local effectiveness.…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective analysis of 420 patients treated with RT and HT reported that 153(36%) participants developed subcutaneous tissue toxicity, ranging from grade 1-3 in severity, with one patient requiring surgical intervention [16]. Acute neurotoxicity following the treatment of deep pelvic tumors with HT is a rare (2.3% incidence) complication which can have an impact on the daily activities of the patient [5,17].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the effects of mEHT on the treatment-related toxicity and quality of life of HIV-positive cervical cancer patients

Minnaar

Kotzen

Naidoo

et al. 2020

International Journal of Hyperthermia

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“…Toxicity from whole-body-HT depends on the patient's general and the physiological conditions during the treatment [81]. Serious toxicity from regional HT perfusion with modern technology and proper choice of perfusate composition, flow rate and pressure, blood gas values, drug doses, temperature dose and scheduling, is limited [118,119].…”

Section: Hyperthermia-induced Toxicitymentioning

confidence: 99%

Thermoradiotheraphy for cancer: an effective approach

Fatehi¹,

Zee²,

Rhoon³

2008

amj

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Hyperthermia (HT) means using controlled temperatures of 40-45°C for cancer treatment. HT is applied with different methods e.g. superficial-HT, locoregional deep-HT, interstitial-HT, intracavity-HT, and whole body-HT. HT can apply in different tumor sites such as breast cancer, melanoma, head and neck, cervix cancer, and glioblastoma. Literatures show that addition of HT to radiotherapy, chemotherapy, or both, will result better tumor response rate, local control, and survival rate; without increasing toxicity. HT can also improve palliative effects in patient. In recent years, due to substantial technical improvements made in achieving selected increase of temperatures in superficial and deep-seated tumors, thermometry, and treatment planning; HT is becoming more clinically accepted in Europe and the USA. HT, as an adjunct cancer treatment modality, is certainly a promising approach; however, it is not well known yet worldwide. Therefore, it seems there is need to know more about that. The purpose of this review is to provide an overview on the application of HT combined with conventional cancer treatment modalities, mainly radiotherapy. The article also introduces mechanism of HT, heating delivery modes, thermometry, and it summarizes results of randomized trials form Western research groups.

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Incidence of acute peripheral neurotoxicity after deep regional hyperthermia of the pelvis

Abstract: Acute neurotoxicity following hyperthermia for pelvic tumours is a rare complication, but can result in symptoms affecting the activities of daily life. We found no patient, tumour or treatment characteristics predictive for a risk of neurotoxicity.

Cited by 6 publications

References 20 publications

Molecular Parameters of Hyperthermia for Radiosensitization

Molecular Parameters of Hyperthermia for Radiosensitization

Analysis of the effects of mEHT on the treatment-related toxicity and quality of life of HIV-positive cervical cancer patients

Thermoradiotheraphy for cancer: an effective approach

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