Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of João Pessoa - PB

Pontes, Thaís Brilhante; Filho, Gilson Mauro Costa Fernandes; Trindade, Arthur de Sousa Pereira; Filho, Jader Freire Sobral

doi:10.1590/abd1806-4841.20132024

Cited by 36 publications

(33 citation statements)

References 13 publications

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“…Whey proteins are predominantly responsible for the insulinotropic effects of milk, whereas casein stimulates IGF-1 to a greater extent than whey [ 56 ]. Hyperinsulinemia, such as that caused by the insulinotropic effects of milk whey proteins, also increases IGF-1 levels, which could provide a potential explanation for why those taking whey supplements, as has become common practice in fitness centers and weights-based athletic pursuits, present with an onset or aggravation of acne [ 57 , 58 ].…”

Section: Diets and Acnementioning

confidence: 99%

Effects of Diet on Acne and Its Response to Treatment

Baldwin¹,

Tan²

2020

Am J Clin Dermatol

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Our understanding of the pathogenesis of acne vulgaris is still evolving. It is known that multiple factors impact acne pathophysiology, including genetic, hormonal, inflammatory, and environmental influences. Because of its implications in many of these factors, diet has been a part of the acne discussion for decades. Several studies have evaluated the significance of the glycemic index of various foods and glycemic load in patients with acne, demonstrating individuals with acne who consume diets with a low glycemic load have reduced acne lesions compared with individuals on high glycemic load diets. Dairy has also been a focus of study regarding dietary influences on acne; whey proteins responsible for the insulinotropic effects of milk may contribute more to acne development than the actual fat or dairy content. Other studies have examined the effects of omega-3 fatty acid and γ-linoleic acid consumption in individuals with acne, showing individuals with acne benefit from diets consisting of fish and healthy oils, thereby increasing omega-3 and omega-6 fatty acid intake. Recent research into the effects of probiotic administration in individuals with acne present promising results; further study of the effects of probiotics on acne is needed to support the findings of these early studies. In this review, we discuss the current evidence regarding the diets of US patients with acne and how they may impact acne and acne treatment.

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Section: Diets and Acnementioning

confidence: 99%

Effects of Diet on Acne and Its Response to Treatment

Baldwin¹,

Tan²

2020

Am J Clin Dermatol

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“… 156 It is of critical concern that milk protein (whey and casein) abuse in the fitness and bodybuilding scenario is associated with the onset and aggravation of acne. 157 – 160 …”

Section: Milkmentioning

confidence: 99%

Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

Melnik¹

2015

CCID

189

177

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Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet. Three major food classes that promote acne are: 1) hyperglycemic carbohydrates, 2) milk and dairy products, 3) saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (PUFAs). Diet-induced insulin/insulin-like growth factor (IGF-1)-signaling is superimposed on elevated IGF-1 levels during puberty, thereby unmasking the impact of aberrant nutrigenomics on sebaceous gland homeostasis. Western diet provides abundant branched-chain amino acids (BCAAs), glutamine, and palmitic acid. Insulin and IGF-1 suppress the activity of the metabolic transcription factor forkhead box O1 (FoxO1). Insulin, IGF-1, BCAAs, glutamine, and palmitate activate the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), the key regulator of anabolism and lipogenesis. FoxO1 is a negative coregulator of androgen receptor, peroxisome proliferator-activated receptor-γ (PPARγ), liver X receptor-α, and sterol response element binding protein-1c (SREBP-1c), crucial transcription factors of sebaceous lipogenesis. mTORC1 stimulates the expression of PPARγ and SREBP-1c, promoting sebum production. SREBP-1c upregulates stearoyl-CoA- and Δ6-desaturase, enhancing the proportion of monounsaturated fatty acids in sebum triglycerides. Diet-mediated aberrations in sebum quantity (hyperseborrhea) and composition (dysseborrhea) promote Propionibacterium acnes overgrowth and biofilm formation with overexpression of the virulence factor triglyceride lipase increasing follicular levels of free palmitate and oleate. Free palmitate functions as a “danger signal,” stimulating toll-like receptor-2-mediated inflammasome activation with interleukin-1β release, Th17 differentiation, and interleukin-17-mediated keratinocyte proliferation. Oleate stimulates P. acnes adhesion, keratinocyte proliferation, and comedogenesis via interleukin-1α release. Thus, diet-induced metabolomic alterations promote the visible sebofollicular inflammasomopathy acne vulgaris. Nutrition therapy of acne has to increase FoxO1 and to attenuate mTORC1/SREBP-1c signaling. Patients should balance total calorie uptake and restrict refined carbohydrates, milk, dairy protein supplements, saturated fats, and trans-fats. A paleolithic-like diet enriched in vegetables and fish is recommended. Plant-derived mTORC1 inhibitors and ω-3-PUFAs are promising dietary supplements supporting nutrition therapy of acne vulgaris.

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“…It was concluded in the same review that protein and amino acid supplements and ephedra-containing dietary supplements potentially have harmful side-effects (7). Furthermore, the progressive use of protein-calorie supplementation was discouraged in a study in Brazil because of its association with the onset of acne within a two-month period (8).…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplement Use in Sport Gyms in Lebanon: Are They Necessary and are There Side-Effects?

Salami

Ghaddar

Aboumrad

et al. 2016

Int J High Risk Behav Addict

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Background: The use of dietary supplements is very common in sport gyms worldwide. However, their use in exercisers in Lebanese gyms has never been investigated. Objectives: The study aim was to evaluate the dietary intake of food macronutrients and to explore any side-effects associated with this kind of consumption. Patients and Methods: Three hundred and sixty exercisers aged 20 -50 years were randomly selected for participation in this crosssectional study. The majority were men (60%) aged 20 -30 years (78%). Results: The intake of dietary supplements was observed in 38% of the study participants, with the highest prevalence in men (73%). It was also found that daily protein intake exceeded dietary needs in 92% of the participants, while daily fat intake was less than that required in 76% of them. It was noteworthy that 63% of supplement users in this study reported having experienced between one and several side-effects. Conclusions: These results indicate a lack of awareness among people who exercise regularly on the benefits and side-effects of dietary supplements. There is an urgent need for the implementation of campaigns that target gym users in Lebanon to raise awareness in this regard.

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Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of João Pessoa - PB

Cited by 36 publications

References 13 publications

Effects of Diet on Acne and Its Response to Treatment

Effects of Diet on Acne and Its Response to Treatment

Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

Dietary Supplement Use in Sport Gyms in Lebanon: Are They Necessary and are There Side-Effects?

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