Incidence, impact, and risk factors of adverse events in thoracic and lumbar spine fractures: an ambispective cohort analysis of 390 patients

Glennie, R. Andrew; Ailon, Tamir; Yang, Kaiyun; Batke, Juliet; Fisher, Charles G.; Dvorak, Marcel F.; Vaccaro, Alexander R.; Fehlings, Michael G.; Arnold, Paul M.; Street, John

doi:10.1016/j.spinee.2014.11.016

Cited by 14 publications

(22 citation statements)

References 22 publications

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“…Patient factors have been shown to be associated with risk of specific AEs including urinary tract infections (UTI), 2 , 7 , 10 pneumonia, 2 , 7 , 11 delirium, 2 , 7 , 12 , 13 and cardiac complications. 10 Advancing age is a significant predictor for increased risk of AEs.…”

Section: Introductionmentioning

confidence: 99%

“… 10 Advancing age is a significant predictor for increased risk of AEs. 1–9 Gender differences in AEs were also found, with males being at higher general risk of AEs, 5 , 7 respiratory complications, 10 and pressure ulcers (PU), 14 and females at higher risk of UTI, 10 delirium, 7 and deep vein thrombosis. 13 …”

Section: Introductionmentioning

confidence: 99%

“…Injury factors such as high energy injury mechanisms, 2 , 7 presence of injuries concurrent to SCI as measured by Injury Severity Score (ISS), 6 , 11 , 15 Glasgow Coma Scale (GCS), 10 , 16 or presence/number of other major injuries 7 , 10 have been shown to increase the risk of AEs. Severity of SCI, as measured by the International Standards for Neurological Classification of SCI (ISNCSCI), 17 also affects risk of AEs because the anatomical region and the completeness of injury affect which body systems are disrupted and the motor and sensory impairment of the patient.…”

Section: Introductionmentioning

confidence: 99%

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Previously Identified Common Post-Injury Adverse Events in Traumatic Spinal Cord Injury—Validation of Existing Literature and Relation to Selected Potentially Modifiable Comorbidities: A Prospective Canadian Cohort Study

Marion

Rivers

Kurban

et al. 2017

Journal of Neurotrauma

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Adverse events (AEs) are common during care in patients with traumatic spinal cord injury (tSCI). Increased risk of AEs is linked to patient factors including pre-existing comorbidities. Our aim was to examine the relationships between patient factors and common post-injury AEs, and identify potentially modifiable comorbidities. Adults with tSCI admitted to a Level I acute specialized spine center between 2006 and 2014 who were enrolled in the Rick Hansen SCI Registry (RHSCIR) and had AE data collected using the Spine Adverse Events Severity system were included. Patient demographic, neurological injury, and comorbidities data were obtained from RHSCIR. Potentially modifiable comorbidities were grouped into health-related conditions, substance use/withdrawal, and psychiatric conditions. Negative binomial regression and multiple logistic regression were used to model the impact of patient factors on the number of AEs experienced and the occurrence of the five previously identified common AEs, respectively. Of the 444 patients included in the study, 24.8% reported a health-related condition, 15.3% had a substance use/withdrawal condition, 8% reported having a psychiatric condition; and 79.3% experienced one or more AEs. Older age (p = 0.004) and more severe injuries (p < 0.001) were nonmodifiable independent variables significantly associated with increased AEs. The AEs experienced by patients were urinary tract infections (42.8%), pneumonia (39.2%), neuropathic pain (31.5%), delirium (18.2%), and pressure ulcers (11.0%). Risk of delirium increased in those with substance use/withdrawal; and pneumonia risk increased with psychiatric comorbidities. Opportunity exists to develop clinical algorithms that include these types of risk factors to reduce the incidence and impact of AEs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Previously Identified Common Post-Injury Adverse Events in Traumatic Spinal Cord Injury—Validation of Existing Literature and Relation to Selected Potentially Modifiable Comorbidities: A Prospective Canadian Cohort Study

Marion

Rivers

Kurban

et al. 2017

Journal of Neurotrauma

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“…According to Fehlings et al all patients with SCI are at high risk for cardiovascular and respiratory complicances [1][2][3]. Moreover the management of patients with acute SCI, whenever possible, in specialized centres is fundamental [8,[10][11][12].…”

Section: Actuality and Future Perspectivesmentioning

confidence: 99%

“…According to the current literature, the incidence of spinal trauma with neurological impairment in Italy is estimated to be between 18 and 20 cases per million [1][2][3]. Usually the most affected patients are young or middle aged, with a male/female ratio of 3,5-4,1 and the trauma is related to road accidents [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%