Incidence et impact de la maladie thrombo-embolique sur la prise en charge du cancer de l’ovaire

Achen, Guillaume; Dolivet, Enora; Turck, M.; Fauvet, R.

doi:10.1016/j.gofs.2020.03.007

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Patients in the GLIM-malnutrition group had a higher incidence of venous thrombosis than those without malnutrition (P=0.035). This finding correlates with Achen et al , who reported that malnutrition is strongly associated with venous thrombosis in patients with malignancy ( 23 ). Moreover, the recent PREHAB trial ( 24 ) has demonstrated optimized post-operative recovery and fewer severe and medical post-operative complications in patients with CRC that underwent a multimodal prehabilitation program before surgery compared with standard care.…”

Section: Discussionsupporting

confidence: 91%

The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery

Shen,

Wen,

Chen

et al. 2023

J Gastrointest Oncol

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Background Elderly people and patients with colorectal cancer (CRC) are both at high risk of malnutrition. Therefore, it is of great significance to explore suitable malnutrition screening and diagnostic indicators for elderly patients with CRC. Recently, the Global Leadership Initiative on Malnutrition (GLIM) proposed new diagnostic criteria for malnutrition. The aim of this article was to evaluate the diagnostic value of GLIM criteria for malnutrition in elderly colorectal patients. We explored the relationship between GLIM-malnutrition, post-operative complications and the long-term prognosis of elderly colorectal patients. Methods Elderly patients (aged ≥65 years) who underwent CRC surgery from January 2015 to December 2018 were included. Malnutrition was diagnosed based on the GLIM criteria. The relationships between GLIM-malnutrition and clinical characteristics were analyzed by t -tests, Mann-Whitney U tests, and chi-squared tests. The relationships between GLIM-malnutrition and post-operative complications were analyzed by chi-squared tests, and logistic regression analyses. The relationships between GLIM-malnutrition and the long-term prognosis were analyzed by Kaplan-Meier analyses and logistic and Cox regression analyses. Results A total of 385 elderly patients were included in this study, and 118 patients (30.65%) were diagnosed with malnutrition according to the GLIM criteria. GLIM-malnutrition was significantly associated with older age, lower body mass index (BMI), lower grip strength, tumor location, higher Nutrition Risk Screening 2002 (NRS-2002), and lower levels of albumin and hemoglobin. GLIM-malnutrition was an independent risk factor [odds ratio (OR): 1.753, 95% confidence interval (CI): 1.100–2.795, P=0.018] for post-operative complications. Cox regression analysis showed that GLIM-malnutrition was an independent risk factor for overall survival in elderly patients with CRC. Conclusions The GLIM criteria are feasible diagnostic criteria for malnutrition of elderly patients with CRC. GLIM-malnutrition is significantly associated with post-operative complications and overall survival in elderly patients with CRC.

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Section: Discussionsupporting

confidence: 91%

The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery

Shen,

Wen,

Chen

et al. 2023

J Gastrointest Oncol

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“…The main treatment methods for OC include surgical resection, drug therapy, and radiation therapy. The overall prognosis of OC patients is poor, and OC is generally difficult to cure [ 4 , 5 ]. The 5-year survival rate of early patients is higher.…”

Section: Introductionmentioning

confidence: 99%

Alkannin Inhibits the Development of Ovarian Cancer by Affecting miR-4461

Wang

Zhang

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Previous studies have shown that alkannin has anticancer, anti-inflammatory, and antibacterial effects. However, the effect of alkannin in the development of ovarian cancer (OC) remains unknown. Therefore, this study aims to elucidate the function of alkannin in OC progression. Methods. RT-qPCR and western blot analysis were used to measure mRNA and protein expression. Cell viability and metastasis were detected by the CCK-8 assay, flow cytometry analysis, and transwell assay. Results. Alkannin had no cytotoxicity toward normal ovarian cells, but alkannin can inhibit cell proliferation and induce apoptosis in OC cells. In addition, alkannin inhibited cell migration and invasion and blocked EMT in OC. Besides, upregulation of miR-4461 was found in OC tissues and cells, which was regulated by alkannin. More importantly, miR-4461 can inverse the effects of alkannin on cell viability and metastasis in OC cells. Conclusion. Alkannin restrains cell viability, metastasis, and EMT in OC by downregulating miR-4461 expression.

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Incidence et impact de la maladie thrombo-embolique sur la prise en charge du cancer de l’ovaire

Cited by 2 publications

References 30 publications

The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery

The relationship between GLIM-malnutrition, post-operative complications and long-term prognosis in elderly patients undergoing colorectal cancer surgery

Alkannin Inhibits the Development of Ovarian Cancer by Affecting miR-4461

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