Incidence et distribution de 1026 thromboses veineuses des membres inférieurs diagnostiquées par écho-Doppler chez 3263 patients atteints de cancer

Bertoïa, A.; Barrellier, M.-T.; NGuyen-Van, V.; Berger, L.; Hello, C. Le

doi:10.1016/j.jmv.2013.05.001

Cited by 5 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Venous thrombosis may reveal cancer, but cancer and its treatments are also risk factors for VTE [8,9]. The characteristics of the thrombosis-associated cancer population are close to those reported in the literature, Whether for the average age between 66 and 69 years, or the slight predominance of females [10,11]. VTE disease affects 10 to 20% of cancer patients [2,3], with a very variable incidence according to the type of cancer considered and its degree of extension, the metastatic stages being much more thrombogenic than the localized stages [2,3,12].…”

Section: Discussionmentioning

confidence: 70%

“…VTE disease affects 10 to 20% of cancer patients [2,3], with a very variable incidence according to the type of cancer considered and its degree of extension, the metastatic stages being much more thrombogenic than the localized stages [2,3,12]. 18 to 34% of patients with VTE have cancer known or discovered at the time of diagnosis of thrombosis [10,13,14,15]. 4 to 10% of patients with idiopathic thrombosis develop cancer within 2 years of diagnosis of VTE [9,13,16,17].…”

Section: Discussionmentioning

confidence: 99%

“…4 to 10% of patients with idiopathic thrombosis develop cancer within 2 years of diagnosis of VTE [9,13,16,17]. This figure increases to 20% in the case of recurrent idiopathic DVT, migratory or bilateral [10,18,19]. VTE disease may be the first manifestation of otherwise completely silent cancer.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Thrombosis and Cancer: Case Series of 25 Patients

Kaddouri¹

2017

AJIM

View full text Add to dashboard Cite

Abstract:The objective of this paper is to describe the clinical and therapeutic characteristics of thrombosis associated with cancers in patients in charge of the internal medicine-oncology department of the Ibn Sina Military Hospital in Marrakech. This is a retrospective, descriptive and analytical study over a two-year period from January 2013 to December 2014. Among 158 patients with cancer, we identified 25 with thrombosis confirmed by imaging. Characteristics of the population of origin, incidence, risk factors for venous thromboembolic disease (VTE), diagnostic means, distribution of thrombosis, location and histological type of cancer and therapeutic strategy were analyzed. The mean age of our patients was 55.89 years, with female predominance (56% vs 44%). The incidence of venous thrombosis in our series is 15.8% (n = 25) of which 76% (n = 19) are isolated, 12% (n = 3) are on central venous catheter (CVC) and 12% (n = 3) are associated with pulmonary embolism. The lower limbs were the most affected (80.3%), with predominance on the left side. Bilateral involvement was found in 7% of cases. Thrombosis was indicative of cancer in 16% of patients (n = 4). While it complicated the development in 84% of the cases (n = 21). Risk factors for VTE were dominated by females (56%), metastases (64%), chemotherapy (80%), and the presence of a CVC (80%). Solid tumors were the most frequent 72% (n = 18) with predominantly digestive cancers (28%), pulmonary (16%), bladder (16%) and breast (12%). The most predominant histological type was adenocarcinoma in 44% (n = 11). The seven cases of malignant hemopathies are: four non-Hodgkin's lymphomas, two multiple myelomas and one case of chronic myeloid leukemia. The initial curative treatment as a relay used low molecular weight heparin in 92% of patients (n = 23). Unfractionated heparin was used in two patients with severe renal failure, the only ones receiving vitamin K antagonist maintenance therapy. Short-term outcomes were favorable in 92% (n = 23), two deaths Have been attributed to severe pulmonary embolism. Significant progress has been made in the context of cancer-related VTE. Nevertheless, there remains a considerable field of unresolved clinical issues. Numerous studies are underway and may lead to advances not only in the treatment of VTE associated with cancer but also in the treatment of the cancerous disease itself.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Thrombosis and Cancer: Case Series of 25 Patients

Kaddouri¹

2017

AJIM

View full text Add to dashboard Cite

show abstract

“…28 In another study of 3,263 patients with cancer and suspected venous thromboembolic disease, 1,026 DVTs were identified but the issue of clot dislodgement was not discussed. 29 To our knowledge, published reports from prospective registries, including DVT-FREE and the Registro Informatizado Pacientes con Enfermedad TromboEmbólica (RIETE) have not discussed this issue, either. 30,31 The fact that several of the isolated prior case reports also assumed to have discussed this phenomenon for the first time is indicative of the challenge to identify prior studies and unfamiliarity of practitioners and investigators with this complication.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Embolism As a Consequence of Ultrasonographic Examination of Extremities for Suspected Venous Thrombosis: A Systematic Review

Mehdipoor

Shabestari

Lip

et al. 2016

Semin Thromb Hemost

View full text Add to dashboard Cite

Ultrasonographic examination for deep vein thrombosis (DVT) appears to be a safe diagnostic method, but a theoretical concern has been raised for dislodgment of thrombi during examination. We conducted a systematic review of the literature to identify reports of possible or confirmed pulmonary embolism (PE) as a consequence of ultrasonographic assessment of extremities in patients with suspected DVT. We searched PubMed for studies published in English from January 1, 1960, to April 10, 2015. We included all cohort studies, case series, and case reports that described PE as a consequence of ultrasonographic assessment of extremities. We excluded studies that reported assessment of areas other than extremities. We screened 3,626 articles, 15 of which reported the issue of clot dislodgement and embolization following ultrasonographic examination of the extremities, including 8 original case reports (7 men and 1 woman). DVTs were in the lower extremities in all eight cases: five in right and three in left lower extremity. In six cases, the femoral veins were involved, and a free-floating thrombus was reported in two cases. Compression ultrasonography was used in all cases, with or without adjunct techniques. Overall, there were seven confirmed and one probable PE cases, two of which had fatal outcomes. Clot embolization is a rare but potential complication of ultrasonic examination for DVT that can lead into PE. Radiologists and clinicians should be aware of this potentially serious phenomenon and avoid excessive pressure when performing ultrasonographic studies of the extremities.

show abstract