Incidence estimation of leukemia among Koreans

Abstract

This study was undertaken in order to estimate the incidence of leukemia among Koreans. Medical records were studied of patients with diagnoses of either ICD-9 038 (septicemia), or 204-208 (leukemias), or 284 (aplastic anemia), or 289 (other diseases of the blood and blood-forming organs) in the claims sent in by medical care institutions throughout the country to the Korea Medical Insurance Corporation (KMIC) during the period from January 1, 1986 to December 31, 1987. These records were abstracted in order to identify and confirm new cases of leukemia among the beneficiaries of KMIC, which covers about 10% of the whole Korean population. Using these data from the KMIC, the incidence rates of leukemia among Koreans were estimated as of July 1st, 1986 to June 30, 1987. The crude incidence rate of all types of leukemia among Koreans is estimated to be 3.45 (95% CI; 0.77-9.55) and 2.29 (95% CI; 0.28-7.81) per 100,000 in males and females, respectively. The cumulative rate for the age span 0-64 is 0.25% in males and 0.18% in females, and for the age span 0-74, 0.35% in males and 0.23% in females. The adjusted rates for the standard world population are 3.90 and 2.48 per 100,000 in males and females, respectively. The relative frequencies by type are 51.5% for AML, 21.6% for ALL, 20.2% for CML, and only 1.5% for CLL. The incidence patterns of various types of leukemia, of which this is the first report in Korea, are analyzed and presented.(ABSTRACT TRUNCATED AT 250 WORDS)

Epidemiology and ethnic aspects of B cell chronic lymphocytic leukemia in Israel

“…[26][27][28] CLL is a rare type of leukemia in Asia and Africa, including China, Saudi-Arabia and Jordan. [4][5][6][7]18,[29][30][31][32][33] In Japan, where CLL is rare, most clinical and laboratory features do not differ from those of Western countries, showing a similar incidence and pattern of cytogenetic aberrations and rearrangement of the bcl-2 and bcl-3 genes. 34 We do not have sufficient data on the exact incidence and epidemiology of CLL in the Mediterranean countries and Eastern Europe; however, an obvious predominance of the disease in the Jewish population has been mentioned occasionally.…”

“…2,3 In Japan, Korea, Singapore, Kuwait and Mexico the disease is significantly less common. [4][5][6][7][8] The incidence of CLL remains low in US Asians and among Japanese who have immigrated to Hawaii which emphasizes racial and/or hereditary factors in the occurrence of this malignant disease. 9,10 CLL was reported to occur frequently in the Jewish population of Brooklyn, NY.…”

Genomic Profile of Chronic Lymphocytic Leukemia in Korea Identified by Targeted Sequencing

“…CLL is a typical malignancy that displays ethnic differences: Although it is one of the most common leukemia in Caucasians, it is extremely rare in Asian countries [1, 2]. While the incidence rate (per 100,000 person-years) of CLL is 3.83 in Caucasians [2], it is only 0.04 in Korea [3], 0.48 in Japan [4], 0.6 in Koreans residing in America, and 0.8 in Chinese residing in America [5]. These data indicate that the incidence rate of CLL is 10- to 20-fold higher in Caucasians than in Eastern populations.…”

miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation

“…Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in the Western societies [1], but low incidence in Asian countries, including China [2, 3]. With the coming of aging society and the westernization of lifestyle, increasing incidence has been reported in recent years in Asia [4].…”