Incidence, Comorbidity, and Mortality of Primary Congenital Glaucoma in Korea from 2001 to 2015: A Nationwide Population-based Study

Abstract

Purpose To report incidence rates of primary congenital glaucoma in Korea and evaluate comorbidity and mortality from 2001 to 2015. Methods This study is a nationwide and retrospective population-based study. We used claims data from the Korean National Health Insurance Service database between 2001 and 2015. Data for all patients diagnosed with primary congenital glaucoma were retrieved using the Korean Electronic Data Interchange and Korean Standard Classification of Diseases-6 codes. Results The number of patients with primary congenital glaucoma between 2001 and 2015 was 776, of which 437 were male (56.31%) and 339 were female (43.69%). The annual prevalence demonstrated a general decreasing trend since 2011, but this was not significant. Over the total survey period, the incidence rate was 11.0 per 100,000 births, with 12.0 cases among males and 10.0 among females. The incidence according to age was 518 (68.78%) patients at age 0, 112 (13.66%) at 1 year, 70 (8.39%) at 2 years, and 76 (9.17%) at 3 years. Of the 776 patients diagnosed with primary congenital glaucoma in the study population, 27 died. The observed mortality per 100,000 people is about 10 times higher than that of the general infant and child population under the age of 4 years. Visual impairment was the most common accompanying disability, followed by brain lesion. Conclusions Our study's estimates of the nationwide population-based incidence of primary congenital glaucoma in a Korean population will expand our understanding of the disease and allow healthcare systems to plan for primary congenital glaucoma.

Surgical Outcomes of Visco-Circumferential-Suture-Trabeculotomy Versus Rigid Probe Trabeculotomy in Primary Congenital Glaucoma: A 3-Year Randomized Controlled Study

“…Both procedures brought about successful control of IOP in operated eyes with a marginal advantage for VCST over VT. Studying the demographics of the study population demonstrates the already established norms of PCG; namely male predominance,10 the bilaterality of the disease process11 and the presentation in the first 6 months of life 12. Almost half of the study children were born to consanguineous parents hence emphasizing the role of heredity and consanguinity in PCG, as already reported 13.…”

Anwendungsmöglichkeiten von „Künstlicher Intelligenz“ und „Big Data“ in der ophthalmologischen Diagnostik

“…So untersuchten verschie-dene Studien einer Arbeitsgruppe mithilfe von "Big Data" zum Beispiel den Zusammenhang zwischen der Entwicklung einer AMD und Rauchen (Raucher wiesen ein 50 % erhöhtes Risiko für die Entwicklung einer exsudativen AMD auf) [39], der Entwicklung einer AMD und sportlicher Aktivität (sportlich aktive Männer hatten ein höheres Risiko für die Entwicklung einer exsudativen AMD) [40] sowie der Entwicklung einer AMD und einer vorhergegangenen Kataraktoperation (für keine AMD-Form bestand ein erhöhtes Risiko) [41]. Dieselbe Arbeitsgruppe untersuchte ebenfalls das Schlaganfallrisiko im Rahmen einer intravitrealen Anti-VEGF-Therapie bei AMD-Patienten [42] sowie die Inzidenz, Komorbiditäten und die Mortalität von Patienten mit primärem kongenitalem Glaukom [43].…”

Epidemiological pattern of Primary Congenital Glaucoma among Egyptian Children aged 0-4 years Attending Minoufia University hospital

“…The study conducted on a nationwide to find a significant decline in the person-year rate since 2011 onward (13) . In another study, in earlier era, PCG comprised 1.46/100,000 person-years in Olmsted County, Minnesota, USA from 1965 to 2004 (2) .…”

“…Epiphora was reported in 24% of cases yet it led to a misdiagnosis with conjunctivitis, NLDO, or uveitis (1%) in the suspected cases. It should be noted that most of the cases seek tertiary healthcare centers in suburbs or towns can lead to missing diagnosis which is common worldwide thus loss of sight can occur (13,14,19) .…”