Incidence, clinicopathological features and genetics of <i>in‐situ</i> follicular neoplasia: a comprehensive screening study in a Japanese cohort

Oishi, Naoki; Segawa, Tomio; Miyake, Kunio; Mochizuki, Kazuki; Kondo, Tetsuo

doi:10.1111/his.14617

Cited by 4 publications

(13 citation statements)

References 21 publications

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“…The rate of ISFN observed in resected lymph nodes is approximately 2%–3%, and the frequency of progression to overt FL is <5%. 2 , 3 , 4 , 5 In this case, the preoperative PET did not indicate metastasis of ISFN; however, it was observed both in the pulmonary nodule and sampled lymph nodes. This indicates that ISFN cells can metastasize lymphatically throughout the body.…”

Section: Discussionmentioning

confidence: 56%

“…ISFN does not require aggressive treatment; however, careful follow‐up is needed. The rate of ISFN observed in resected lymph nodes is approximately 2%–3%, and the frequency of progression to overt FL is <5% 2–5 . In this case, the preoperative PET did not indicate metastasis of ISFN; however, it was observed both in the pulmonary nodule and sampled lymph nodes.…”

Section: Discussionmentioning

confidence: 63%

“…This indicates that ISFN cells can metastasize lymphatically throughout the body. Cells may be found in the blood and lymph nodes throughout the body in ISFN cases 5 . Metastasis implies that the disease will recur or increase in size, as in thymoma, and it may even transform into FL.…”

Section: Discussionmentioning

confidence: 99%

“…Cells may be found in the blood and lymph nodes throughout the body in ISFN cases. 5 Metastasis implies that the disease will recur or increase in size, as in thymoma, and it may even transform into FL. The accurate differentiation between the ISFN and FN is challenging but of great importance to avoid overtreatment 6 ; therefore, careful follow‐up is necessary.…”

Section: Discussionmentioning

confidence: 99%

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In situ follicular neoplasm discovered as an enlarging pulmonary nodule complicated by pulmonary aspergillosis

et al. 2023

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In situ follicular B cell neoplasm, previously known as follicular lymphoma in situ, is a neoplastic proliferation of follicular lymphoma-like B cells confined to the germinal centers. Herein, we report a case of a woman in her 70s who initially presented with several enlarged abdominal lymph nodes. Seven months later during follow-up, a solitary pulmonary nodule was detected. As it was close to the hilum, lobectomy was performed. The intraoperative frozen section showed fibrosis and a collection of lymphocytes and macrophages. Therefore, the lymph nodes were sampled. Station 4 and 10 lymph nodes exhibited similar tumor cells and were immunohistochemically positive for CD10 and BCL2. Thus, the patient was diagnosed with in situ follicular neoplasm and is currently under observation. In situ follicular neoplasm is typically a slowly progressive neoplasm; however, it can present as a rapidly enlarging pulmonary nodule complicated by pulmonary aspergillosis.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In situ follicular neoplasm discovered as an enlarging pulmonary nodule complicated by pulmonary aspergillosis

et al. 2023

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“…Four studies have investigated the incidence of isolated ISFN. 24 , 25 , 29 , 30 These studies examined LNs from individuals who underwent surgery, including lymphadenectomy for solid tumors or inflammatory conditions, using immunohistochemistry ( Table 1 ). The reported incidence of isolated ISFN ranged from 2.0% (2 of 100) to 3.2% (11 of 341).…”

Section: In Situ Follicular B-cell Neoplasm (Isfn)mentioning

confidence: 99%

Precursory or early lesions of follicular lymphoma: clinical features, pathology, and genetics

Oishi

2023

J Clin Exp Hematopathol

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Follicular lymphoma (FL) is an indolent B-cell lymphoma with a germinal center (GC) B cell phenotype that typically harbors t(14;18)(q32;q21). t(14;18) juxtaposes IGH on 14q32 and BCL2 on 18q21, resulting in overexpression of the anti-apoptotic BCL2 protein. However, t(14;18) is also found in the peripheral blood or lymphoid nodes (LNs) of otherwise healthy individuals. Moreover, overt FL has several additional gene alterations involved in epigenetic modification, JAK/STAT signaling, immune modulation, and NF-κB signaling, indicating multi-step lymphomagenesis in FL. There are two early or precursory lesions of FL: t(14;18)-positive cells in the peripheral blood of otherwise healthy individuals and in situ follicular B-cell neoplasm (ISFN). t(14;18)-positive cells are found in 10%–50% of healthy populations, and their incidence and frequency increase with age. The detection of t(14;18) in peripheral blood is a predictive factor for an increased risk of overt FL development. In contrast, ISFN is a histopathologically recognizable precursory lesion, in which t(14;18)-positive cells are confined to the GC of otherwise reactive LNs. ISFN is usually detected incidentally, with an incidence ranging from 2.0% to 3.2%. Occasional ISFN cases have concurrent or metachronous clonally related overt FL or aggressive B-cell lymphoma of a GC phenotype. t(14;18)-positive cells in peripheral blood and isolated ISFN, by themselves, are asymptomatic with limited clinical significance; however, investigations of t(14;18)-positive precursory or early lesions offer meaningful insights into the pathogenesis of FL. This review summarizes the epidemiology, clinical features, pathology, and genetics of precursory or early lesions of FL.

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Follicular Lymphoma in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Biological Data

Kurz

Kalmbach

Ott

et al. 2023

Cancers

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The conceptual description of Follicular lymphoma (FL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) has undergone significant revision. The vast majority of FL (85%) with a follicular growth pattern are composed of centrocytes and centroblasts, harbor the t(14;18)(q32;q21) translocation and are now termed classic FL (cFL). They are set apart from three related subtypes, FL with predominantly follicular growth pattern, FL with unusual cytological features (uFL) and follicular large B-cell lymphoma (FLBCL). In contrast to the revised 4th edition of the WHO classification of haematolymphoid tumors (WHO-HAEM4R), grading of cFL is no longer mandatory. FL with a predominantly diffuse growth pattern had been previously recognized in WHO-HAEM4R. It frequently occurs as a large tumor in the inguinal region and is associated with CD23 expression. An absence of the IGH::BCL2 fusion and frequent STAT6 mutations along with 1p36 deletion or TNFRSF14 mutation is typical. The newly introduced subtype of uFL includes two subsets that significantly diverge from cFL: one with “blastoid” and one with “large centrocyte” variant cytological features. uFL more frequently displays variant immunophenotypic and genotypic features. FLBCL is largely identical to WHO-HAEM4R FL grade 3B and renaming was done for reasons of consistency throughout the classification. In-situ follicular B-cell neoplasm, pediatric-type FL, duodenal-type FL and primary cutaneous follicle center lymphoma are categorized as discrete entities. In addition, novel findings concerning underlying biological mechanisms in the pathogenesis of early and systemic follicular lymphoma will be presented.

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Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort

Cited by 4 publications

References 21 publications

In situ follicular neoplasm discovered as an enlarging pulmonary nodule complicated by pulmonary aspergillosis

In situ follicular neoplasm discovered as an enlarging pulmonary nodule complicated by pulmonary aspergillosis

Precursory or early lesions of follicular lymphoma: clinical features, pathology, and genetics

Follicular Lymphoma in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Biological Data

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