Incidence, Clinical Characteristics, and Timing of Objectively Diagnosed Venous Thromboembolism During Pregnancy

Gherman, Robert B.; Goodwin, T. Murphy; Leung, Belinda; Byrne, James D.; HETHUMUMI, REHENA; Montoro, Martin

doi:10.1097/00006250-199911000-00017

Cited by 67 publications

(69 citation statements)

References 18 publications

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“…Gherman et al 39 reported that the risk of venous thromboembolism begins early in pregnancy, with approximately half of antepartum DVT cases occurring before 15 weeks of gestation. Therefore, it is perhaps surprising that although sP-selectin levels were higher in the pregnant women at 12 weeks of gestation, and indeed after delivery, they did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Soluble P-selectin levels during normal pregnancy: a longitudinal study

Holmes¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To investigate soluble P-selectin (sP-selectin) levels and platelet parameters in normal pregnant women compared with non-pregnant control subjects. Design A longitudinal case -control study.Setting Obstetric outpatient clinic in the Jubilee Maternity Hospital, Belfast.Population One hundred and twenty normal pregnant women and 41 non-pregnant age-matched control subjects. Methods The plasma concentration of sP-selectin in pregnant women sampled at 12, 20 and 35 weeks of gestation, and, in a subgroup at three days postpartum, and non-pregnant controls sampled in parallel, was determined using a commercial quantitative sandwich immunoassay kit. Platelet parameters on each blood sample were also recorded using a SYSMEX SE 9500 analyser. Main outcome measures Plasma sP-selectin as a measure of platelet activation in normal pregnancy.Results Soluble P-selectin was significantly higher in pregnant women than in non-pregnant control subjects at 20 and 35 weeks of gestation, ( P < 0.01, and P < 0.001, respectively). Correlation analyses showed positive correlation between sP-selectin and platelet count in pregnant women at 20 and 35 weeks of gestation (r ¼ 0.247, P < 0.05 and r ¼ 0.360, P < 0.001, respectively). Soluble P-selectin concentration per platelet was also significantly higher in pregnant women than in non-pregnant control subjects at 20 and 35 weeks of gestation ( P < 0.001). Conclusions Our results show that sP-selectin concentration is significantly higher in the second and third trimester of pregnancy when compared with non-pregnant control subjects sampled in parallel. This finding clarifies previous conflicting results on platelet activation in normal pregnancy, and is in agreement with those earlier studies which reported, using other methods, increased platelet activation in normal pregnancy.

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Section: Discussionmentioning

confidence: 99%

Soluble P-selectin levels during normal pregnancy: a longitudinal study

Holmes¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…The reducuction in AT level in acquired type continues until 24 hours following delivery or termination of pregnancy. If AT serum level as a most important natural agent for the anti-coagulation of blood remains in the lower level by delaying in the delivery or termination of pregnancy, it may be associated with dangerous events like a TE in women, especially when other thrombophilia states such as cardiac surgery and CPB are added to others risk factors (9). The risk of TE increases tenfold in the presence of preeclampsia or multi-fetal pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Congenital Antithrombin Deficiency in a Pregnant Woman with Right Atrium Thrombosis

Sabzi

Khosravi

Faraji

2015

Ethiop J Health Sci

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“…13,21,24,41,42 Other risk factors for VTE and their respective relative risks are listed in Table 1.…”

Section: Other Risk Factorsmentioning

confidence: 99%

“…6 The prevalence of VTE is 0.5 to 2.2 cases in every 1,000 births, depending on the population studied. 7,[11][12][13][14][15][16] The absolute incidence of VTE during pregnancy and the puerperium was 107 per 100,000 woman-years in the United Kingdom (UK) 17 and 175 per 100,000 woman-years in Denmark and Canada.…”

Section: Introductionmentioning

confidence: 99%

Profilaxia de tromboembolismo venoso na gestação

Oliveira¹,

Marques

2016

J. vasc. bras.

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Venous thromboembolism is a major cause of obstetric morbidity and mortality. During pregnancy, the risk of occurrence increases between five and ten times when compared to women of the same age who are not pregnant. Compounding this is the fact that pregnant women present certain characteristics that make diagnosis more difficult using clinical signs (high frequency of pain and swelling in the lower limbs), echographic examination (lower sensitivity and specificity for diagnosis of iliac vein thrombosis as pregnancy progresses), and laboratory findings (D-dimer levels progressively increase throughout pregnancy). Conducting careful stratification of women' s venous thromboembolism risk before pregnancy could reduce the incidence of this disease, which is frequent and difficult to diagnose during pregnancy, and of its complications.Keywords: venous thrombosis; prophylaxis; pregnancy. ResumoO tromboembolismo venoso é importante causa de morbidade e mortalidade obstétrica. Durante a gestação, o risco de sua ocorrência aumenta entre cinco e dez vezes quando comparado ao de mulheres não gestantes de mesma idade. Associado a esse fato, a gestante apresenta algumas limitações para o diagnóstico clínico (alta frequência de dor e edema nos membros inferiores), ecográfico (menor sensibilidade e especificidade no diagnóstico de trombose venosa de ilíaca com a evolução da gestação) e laboratorial (o D-dímero apresenta aumento progressivo no decorrer da gravidez). Uma estratificação criteriosa de risco de tromboembolismo venoso de cada mulher antes da gestação pode diminuir a incidência dessa doença, frequente e de difícil diagnóstico na gravidez, e suas complicações.

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Incidence, Clinical Characteristics, and Timing of Objectively Diagnosed Venous Thromboembolism During Pregnancy

Cited by 67 publications

References 18 publications

Soluble P-selectin levels during normal pregnancy: a longitudinal study

Soluble P-selectin levels during normal pregnancy: a longitudinal study

Congenital Antithrombin Deficiency in a Pregnant Woman with Right Atrium Thrombosis

Profilaxia de tromboembolismo venoso na gestação

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