Incidence, characteristics, and outcomes of patients with bone and joint infections due to community-associated methicillin-resistant Staphylococcus aureus: a systematic review

Abstract

To summarize the published evidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) bone and joint infections. PubMed and Scopus electronic databases were searched. The annual incidence of invasive CA-MRSA infections ranged from 1.6 to 29.7 cases per 100,000, depending on the location of the population studied; bone and joint infections accounted for 2.8 to 43 % of invasive CA-MRSA infections. Surveillance studies showed that patients <2 years of age are mainly affected. Incidence rates were higher in blacks. Sixty-seven case reports and case series were identified; the majority of the patients included were children. Vancomycin and clindamycin were used effectively, in addition to surgical interventions. Seven patients out of 413 died (1.7 %) in total. Chronic osteomyelitis developed in 19 patients (data for 164 patients were available). The published evidence for CA-MRSA bone and joint infections refers mainly to children; their incidence depends on the location and race of the population. Vancomycin and clindamycin have been used effectively for their treatment.

Estudio descriptivo de infecciones osteo-articulares en niños en tiempos de Staphylococcus aureus resistente a meticilina de la comunidad (SARM-Co)

“…Sin embargo, la normalización de la PCR fue más tardía, lo que conllevó a una mayor duración del tratamiento antimicrobiano total y a la prolongación de la estancia hospitalaria. La mayor duración del tratamiento y el requerimiento de drenaje han sido reportados en la literatura de las infecciones osteo-articulares por SARM-Co, lo que corrobora este reporte [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . En SARM-Co, las secuelas son más frecuentes.…”

Phenotypic, molecular and antimicrobial susceptibility assessment in isolates from chronic ulcers of cured leprosy patients: a case study in Southern Brazil

“…However, in recent years, community-acquired MRSA infection has been reported in several countries. 22,23,24 Community MRSA isolates are a frequent cause of skin and soft tissue infections, such as cellulitis and abscess. 25,26,27 However, they may also be implicated in severe infectious conditions, such as meningitis, pneumonia, bacteremia, and septic shock.…”

Trends in the Epidemiology of Osteomyelitis

“…Similarly, improved life expectancy among elderly patients with diabetes mellitus has resulted in more cases of neuropathy, vascular insufficiency, and the associated local complications of soft-tissue loss, bone destruction, and osteomyelitis 17,18 . To date, however, there are only a handful of epidemiological studies of osteomyelitis in the U.S., and these studies are limited to selected subsets of patients, as defined by age 19 , osteomyelitis type 20 , anatomical location 21 , or infecting organisms 22,23 . To our knowledge, there are no comprehensive epidemiological studies describing the entire spectrum of osteomyelitis in the U.S. With this background, our objective was to examine trends in the age and sex-specific incidence of osteomyelitis over a forty-one-year period from 1969 to 2009.…”