Incidence, Causes, and Outcomes of Dilated Cardiomyopathy in Children

Abstract

In children, DCM is a diverse disorder with outcomes that depend largely on cause, age, and heart failure status at presentation. Race, sex, and age affect the incidence of disease. Most children do not have a known cause of DCM, which limits the potential for disease-specific therapies.

Association Between Serial B‐Type Natriuretic Peptide Levels, Vasoactive Drug Weaning, and Adverse Cardiovascular Outcomes in Pediatric Heart Failure

“…In contrast to previously published pediatric HF data, 2 , 10 neither age nor LV systolic performance were independently associated with ACV outcomes in our cohort. We attribute this difference in part to the degree of acuity in our patient cohort, who appear to have had a uniformly more severe degree of LV dysfunction, perhaps negating this variable as a valuable predictor of outcome.…”

Long-Term Outcomes and Prognosticators of Pediatric Primary Dilated Cardiomyopathy in an Asian Cohort

“…Lower incidence of either ECMO or LVAD implantation in younger aged patients might also reflect more favorable clinical outcomes in this patient subgroup. This is concordant with several reports from western countries ( 3 , 18 – 21 ). In addition, we demonstrated that younger age at diagnosis may be related to higher probability of LV function recovery.…”

“…We demonstrated that age at diagnosis is a crucial prognosticator of clinical outcomes in an Asian cohort of pediatric primary DCM. At a younger age, although the This is concordant with several reports from western countries (3,(18)(19)(20)(21). In addition, we demonstrated that younger age at diagnosis may be related to higher probability of LV function recovery.…”

Dilated Cardiomyopathy in Children: A Diverse Etiological Profile

“…Three cases remained without an identified etiology. These findings are consistent with the literature, where idiopathic forms remain predominant (up to 76%), followed by myocarditis (12%) and familial forms (7%) [ 13 , 17 , 10 ]. The relatively low proportion of idiopathic cases in our series may reflect an extensive diagnostic approach.…”