Incidence and trends of middle ear cholesteatoma surgery and mastoidectomy in Australia—A national hospital morbidity database analysis

Li, J.; Jufas, Nicholas; Forer, Martin; Patel, Nirmal

doi:10.1002/lio2.709

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence rate of cholesteatoma is estimated at 5-9.2 per 100,000 per year [2][3][4][5][6]. The familial occurrence of cholesteatoma is the basis for investigating the genetic background of the disease [7,8], although a family history in this disease is nevertheless quite rare and can only explain a limited number of cases [9].…”

Section: Introductionmentioning

confidence: 99%

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

Dżaman,

Czerwaty,

Reichert

et al. 2023

IJMS

View full text Add to dashboard Cite

Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes. MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.

show abstract