Incidence and Treatment Protocol for Maxillofacial Fungal Osteomyelitis: A 12-Year Study

Anehosur, Venkatesh; Agrawal, Sayli M.; Joshi, Vajendra K.; Anand, Jawahar; Krishnamuthy, Keerthana; Kumar, Niranjan

doi:10.1016/j.joms.2019.06.187

Cited by 12 publications

(18 citation statements)

References 23 publications

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“…The majority of pathogens causing mandibular osteomyelitis were alpha-hemolytic streptococcus, staphylococcus, and actinomyces. 7,8 Mandibular osteomyelitis induced by filler injection is rare. There are several possibilities for the cause of the infection in the case presented.…”

Section: Discussionmentioning

confidence: 99%

“…Mandibular osteomyelitis, uncommon in developed regions, may occur by direct inoculation of pathogens into the bone, by the spread from an adjacent area of infection or by the seeding of the infection from a nonadjacent site via the blood supply 5,6 . Most cases of mandibular osteomyelitis were reported after dental infections, oral surgery, or mandibular fractures.…”

Section: Discussionmentioning

confidence: 99%

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Mandibular osteomyelitis after hyaluronic acid injection

Wang

Long

et al. 2020

J of Cosmetic Dermatology

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Background Mandibular osteomyelitis after filler injection is extremely rare. Aims We reported a case of mandibular osteomyelitis after hyaluronic acid injection. Patients A 33‐year‐old woman received 1 mL hyaluronic acid injection on her chin 1 year ago, after which her chin kept swelling and painful, and gradually ulcerated with pus flowing out. She received antibiotics, debridement procedures, negative pressure wound therapy, and hyperbaric oxygen therapy without symptoms improved. Cone‐beam computed tomography scan showed local bone destruction, sequestrum formation, and tissue calcification on the right mandible body. The patient was diagnosed with mandibular osteomyelitis and received local curettage for the removal of necrotized bone. Results Literature search found no case reports on mandibular osteomyelitis after filler injection so far. Conclusion Minimizing the risk of contamination and infection is strictly required during the filler injection process. Once the patient shows signs of incurable mandibular infection postoperation, clinicians should consider the possibility of osteomyelitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mandibular osteomyelitis after hyaluronic acid injection

Wang

Long

et al. 2020

J of Cosmetic Dermatology

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“…(2%). 2 Prakash H and Chakrabarthi A reported the prevalence of mucormycosis in India to be 0.02 to 9.5 cases per 100 000 population which is 70 times more than global data. 3 …”

Section: Introductionmentioning

confidence: 93%

“… 1 Opportunistic funguses invade the arteries leading to thrombosis and further compromised blood supply to the soft and hard tissues of the affected region causing osteomyelitis. 2 We have termed the fungal osteomyelitis of jaws occurring in COVID-19 recovered patients as COVID-19Associated Fungal Osteomyelitis of Jaws and sinuses (CAFOJS).…”

Section: Introductionmentioning

confidence: 99%

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Covid-19-associated fungal osteomyelitis of jaws and sinuses: An experience-driven management protocol

et al. 2022

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Invasive fungal co-infections with COVID-19 are currently being reported at an alarming rate. Our study explores the importance of early identification of the disease, probable etiopathogenesis, clinical and radiological features and a treatment protocol for covid-19 associated fungal osteomyelitis of jaws and sinuses (CAFOJS). A one-year prospective study from June 2020 to May 2021 was conducted among CAFOJS diagnosed patients in a tertiary care centre in South India. Demographic details, COVID-19 infection and treatment history, time taken for initiation of symptoms after COVID-19 diagnosis, medical history, clinical features were recorded. All the patients were managed with a standard diagnostic and intervention protocol including pre-operative and post-operative administration of Inj. Amphotericin B 50 mg (liposomal) and early aggressive surgical debridement. Thirty-nine (78%) patients were diagnosed with CAFOJS out of 50 osteomyelitis patients reported to our centre. 32 patients gave history of diabetes (82%) and 3 patients (8%) were diagnosed as diabetic on reporting to us. 21 patients (54%) patients were known to receive steroids during the COVID-19 treatment. Sole existence of Mucorales spp. was seen in 30 patients (77%), Aspergillus fumigatus in 2 patients (5%), Curvularia spp. in 2 patients (5%). Concomitant existence of Mucorales and Aspergillus fumigatus was reported in two patients (5%) and Candida albicans in 3 patients (8%). Patients underwent treatment with standard protocol and no recurrence noted. CAFOJS is a clinical entity with aggressive presentation and warrants early diagnosis and treatment.

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