Incidence and Treatment Outcome of Radiation Pneumonitis in Patients With Limited-stage Small Cell Lung Cancer Treated With Concurrent Accelerated Hyperfractionated Radiation Therapy and Chemotherapy

Doshita, Kosei; Tabuchi, Yuya; Omori, Shota; Kawabata, Takanori; Kodama, Hitoshi; Nishioka, Naoya; Miyawaki, Eriko; Iida, Yuko; Mamesaya, Nobuaki; Kobayashi, Hiroyoshi; Ko, Ryo; Wakuda, Kazushige; Ono, Akira; Naito, Tateaki; Murakami, Haruyasu; Mori, Keita; Harada, Hideyuki; Kaneko, Takeshi; Takahashi, Toshiaki

doi:10.1016/j.adro.2022.101129

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The benefits of radiotherapy are numerous, including a low risk of adverse effects, relatively low cost compared to other cancer treatments, and the ability to accurately target and destroy cancer cells while sparing healthy tissue. In addition, it may be used in combination with other therapies such as chemotherapy 4 , 5 and phototherapy 1 , 6 in order to improve the overall efficacy of the treatment plan. However, it should be noted that there are also certain drawbacks associated with radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Ghaffarlou,

Rashidzadeh,

Mohammadi

et al. 2024

Sci Rep

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Radiation therapy and phototherapy are commonly used cancer treatments that offer advantages such as a low risk of adverse effects and the ability to target cancer cells while sparing healthy tissue. A promising strategy for cancer treatment involves using nanoparticles (NPs) in combination with radiation and photothermal therapy to target cancer cells and improve treatment efficacy. The synthesis of gold NPs (AuNPs) for use in biomedical applications has traditionally involved toxic reducing agents. Here we harnessed dopamine (DA)-conjugated alginate (Alg) for the facile and green synthesis of Au NPs (Au@Alg-DA NPs). Alg-DA conjugate reduced Au ions, simultaneously stabilized the resulting AuNPs, and prevented aggregation, resulting in particles with a narrow size distribution and improved stability. Injectable Au@Alg-DA NPs significantly promoted ROS generation in 4T1 breast cancer cells when exposed to X-rays. In addition, their administration raised the temperature under a light excitation of 808 nm, thus helping to destroy cancer cells more effectively. Importantly, no substantial cytotoxicity was detected in our Au@Alg-DA NPs. Taken together, our work provides a promising route to obtain an injectable combined radio enhancer and photothermally active nanosystem for further potential clinic translation.

show abstract

Section: Introductionmentioning

confidence: 99%

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Ghaffarlou,

Rashidzadeh,

Mohammadi

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The bene ts of radiotherapy are numerous, including a low risk of adverse effects, relatively low cost compared to other cancer treatments, and the ability to accurately target and destroy cancer cells while sparing healthy tissue. In addition, it may be used in combination with other therapies such as chemotherapy [4][5] and phototherapy 1,6 in order to improve the overall e cacy of the treatment plan. However, it should be noted that there are also certain drawbacks associated with radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Catechol-Conjugated Alginate Biopolymer for Eco-Friendly Synthesis of Gold Nanoparticles: A Promising Approach for Photothermal and Radiotherapy in Breast Cancer Treatment

Ghaffarlou,

Rashidzadeh,

Mohammadi

et al. 2023

Preprint

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Radiation therapy and phototherapy are commonly used treatments for cancer that offer advantages such as a low risk of adverse effects and the ability to target cancer cells while sparing healthy tissue. A promising strategy for cancer treatment involves using nanoparticles (NPs) in combination with radiation and photothermal therapy to target cancer cells and improve treatment efficacy. The synthesis of gold NPs (AuNPs) for use in biomedical applications has traditionally involved toxic reducing agents. Here we harnessed dopamine (DA)-conjugated alginate (Alg) for the facile and green synthesis of Au NPs (Au@Alg-DA NPs). Alg-DA conjugate reduced Au ions, simultaneously stabilized the resulting AuNPs and prevent aggregation, resulting in particles with a narrow size distribution and improved stability. Injectable Au@Alg-DA NPs significantly promoted ROS generation in 4T1 breast cancer cells when exposed to X-rays. In addition, their administration raised the temperature under a light excitation of 808 nm, thus helping to destroy cancer cells more effectively. Importantly, no substantial cytotoxicity was detected in our Au@Alg-DA NPs. Taken together, our work provides a promising route to obtain an injectable combined radioenhancer and photothermally active nanosystem for further potential clinic translation.

show abstract

Incidence and Treatment Outcome of Radiation Pneumonitis in Patients With Limited-stage Small Cell Lung Cancer Treated With Concurrent Accelerated Hyperfractionated Radiation Therapy and Chemotherapy

Cited by 2 publications

References 32 publications

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Catechol-Conjugated Alginate Biopolymer for Eco-Friendly Synthesis of Gold Nanoparticles: A Promising Approach for Photothermal and Radiotherapy in Breast Cancer Treatment

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