Incidence and Treatment of Tracheal Cancer: A Nationwide Study in The Netherlands

Honings, Jimmie; Dijck, J.A.A.M. van; Verhagen, Ad F. T. M.; Heijden, Erik H F M van der; Marres, H.A.M.

doi:10.1245/s10434-006-9229-z

Cited by 114 publications

(120 citation statements)

References 30 publications

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“…4,5 The actual treatment of tracheal cancer in the Netherlands as reported for the period 1989 to 2002 consisted of resection in only 12% of cases. 6 Similar proportions were found in epidemiologic studies from Denmark and Finland. 7,8 The discrepancy between reported ratios of surgical clinics and these epidemiologic studies may be partly based on patient selection.…”

supporting

confidence: 76%

“…6 The high rate of small cell carcinoma in our previous study (11.0%), regarded as a marker of contamination with metastatic disease, was likely caused by the misclassification of peripheral bronchial carcinomas. 12 We estimate that ACC accounts for approximately one-quarter of tracheal cancers.…”

Section: Discussionmentioning

confidence: 71%

“…Ten patients were first seen at a tertiary center. Referral to tertiary centers occurred in 9 cases for treatment and in 18 Yes (31) Yes (28) No (3) Yes (14) Yes (6) No (13) No ( for a second opinion, while 13 (26%) were not referred. Median diagnostic delay was 9 days (mean 24 days) and ranged from 0 to 285 days.…”

Section: Patient Characteristics and Disease Manifestationmentioning

confidence: 99%

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Undertreatment of Tracheal Carcinoma: Multidisciplinary Audit of Epidemiologic Data

et al. 2008

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National epidemiologic data were examined to determine the eligibility for curative therapy in tracheal carcinoma. An expert audit of primary tracheal carcinomas registered from 2000 to 2005 with the Netherlands Cancer Registry (NCR) included blinded patient data and radiographic review to assess diagnosis and resectability. Actual treatment was compared with the opinions of a multidisciplinary panel (Radboud panel) and a second reviewer. Of 101 NCR-registered primary tracheal carcinomas, the Radboud panel diagnosis was metastatic disease or local extension of adjacent tumors in 34. Seventeen cases were excluded for missing data. In 50 cases confirmed by panel and a second reviewer, actual treatment consisted of surgery in 12 (24%), radiotherapy in 29 (58%), endobronchial treatment in 6 (12%), and observation in 3 (6%). Both panel and second reviewer identified 16 additional surgical candidates, a total of 28 (56%) of 50. Treatment recommendations of panel and second reviewer disagreed in four cases (8%). One-third of NCR-registered primary tracheal carcinomas were misclassified nontracheal primary tumors involving the trachea. A majority of cases meeting audit criteria for diagnosis and surgical resection was treated with other modalities. Interreviewer disagreement was small. The audit of a national cancer registry suggests that incorrect diagnosis and undertreatment are common in rare airway tumors.Primary malignancies of the trachea are rare and challenging tumors. Surgical resection of the involved tracheal segment is the treatment of choice, and long-term diseasefree survival has been reported after tracheal resection.

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supporting

confidence: 76%

Section: Discussionmentioning

confidence: 71%

Section: Patient Characteristics and Disease Manifestationmentioning

confidence: 99%

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Undertreatment of Tracheal Carcinoma: Multidisciplinary Audit of Epidemiologic Data

et al. 2008

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“…Primary tracheal tumors show a incidence of approximately 0.1 in every 100,000 persons per year, squamous cell carcinomas and adenoid cystic carcinomas accounting for about two-thirds of them, whereas chondrosarcoma is an exceptional occurrence with only 24 cases described so far [4][5][6][7]. The mean age of the patients reported…”

Section: Discussionmentioning

confidence: 99%

Gradually worsening dyspnea and dry cough in an elderly patient

Barisione¹,

Rossi²,

Salio³

2017

Monaldi Arch Chest Dis

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Primary tracheal chondrosarcomas are an extremely rare condition that affect adult of all ages, 24% being more that 70 years old. The progression may be slow, with symptoms that may continue up to 72 months before diagnosis is made. The clinical manifestations, that include a combination of nonproductive cough, wheezing, and dyspnea without hemoptysis often leads to misdiagnosis of asthma or chronic obstructive pulmonary disease. We report a case of an 87-year-old male, a Medical Doctor, with such a history, in whom a diagnosis of a tracheal chondrosarcoma was finally performed, 12 months after the first manifestation of the disease.

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“…Primary malignant tracheal tumors are extremely rare and comprise a mere 0.2% of all malignant tumors of the respiratory tract [10]. Sarcomatoid carcinoma of the trachea is even more rare, with the first case being reported in 2009 in Turkey [7].…”

Section: Discussionmentioning

confidence: 99%

A Rare Collision Tumor: Tracheal Sarcomatoid Carcinoma Invading a Papillary Thyroid Carcinoma

Sokoya¹,

Thomas²,

Eustaquio³

2017

OALib

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A collision tumor involving a tracheal sarcomatoid carcinoma and a papillary thyroid carcinoma has never been reported in the literature. A 78-year-old female presented with a large neck mass and hoarseness. A fine needle aspiration demonstrated papillary thyroid carcinoma. Imaging revealed a right thyroid mass invading into the tracheal lumen with bulky ipsilateral lymphadenopathy. The patient underwent a total thyroidectomy, tracheal resection, and central and right neck dissections. Pathology demonstrated a tracheal sarcomatoid carcinoma invading the right thyroid, which had multifocal papillary thyroid carcinoma with central and lateral neck metastases. The patient subsequently received adjuvant chemoradiotherapy and radioactive iodine. We present a case of a tracheal sarcomatoid carcinoma colliding with a papillary thyroid cancer. Treatment modalities should address the most aggressive tumor, while being tailored to clinical picture, tumor histology, and patient preferences.

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Incidence and Treatment of Tracheal Cancer: A Nationwide Study in The Netherlands

Cited by 114 publications

References 30 publications

Undertreatment of Tracheal Carcinoma: Multidisciplinary Audit of Epidemiologic Data

Undertreatment of Tracheal Carcinoma: Multidisciplinary Audit of Epidemiologic Data

Gradually worsening dyspnea and dry cough in an elderly patient

A Rare Collision Tumor: Tracheal Sarcomatoid Carcinoma Invading a Papillary Thyroid Carcinoma

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