Incidence and survival variations of upper tract urothelial cancer in Taiwan (2001–2010)

Lin, Ming‐Yen; Niu, Sheng‐Wen; Li, Weiming; Lee, Huei-Lan; Chen, Li-Tzong; Hwang, Shang‐Jyh

doi:10.1111/iju.14731

Cited by 10 publications

(16 citation statements)

References 25 publications

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“…Seven clusters of urbanization stratification were grouped into four levels: high, medium–high, medium, and low urbanization, according to the previously published consensus methodology 45 . Clusters of high bladder cancer incidence rate in the black-foot disease endemic regions included six southwestern coastal townships where people unknowingly drank arsenic-contaminated well water before tap water installation in 1979–2003 46 – 48 . The study subjects originating from these regions were identified and regarded as a confounder for adjustment in the multivariate Cox models.…”

Section: Methodsmentioning

confidence: 99%

Long-term ambient hydrocarbon exposure and incidence of urinary bladder cancer

Zhang

Tsai

Kok

et al. 2022

Sci Rep

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Particulate matter and volatile organic compounds, including total hydrocarbons (THCs), are major ambient air pollutants. Primary nonmethane hydrocarbons (NMHCs) originate from vehicle emissions. The association between air pollution and urinary bladder cancer (UBC) is debatable. We investigated whether long-term exposure to ambient hydrocarbons increases UBC risk among people aged ≥ 20 years in Taiwan. Linkage dataset research with longitudinal design was conducted among 589,135 initially cancer-free individuals during 2000–2013; 12 airborne pollutants were identified. Several Cox models considering potential confounders were employed. The study outcomes were invasive or in situ UBC incidence over time. The targeted pollutant concentration was divided into three tertiles: T1/T2/T3. The mean age of individuals at risk was 42.5 (SD 15.7), and 50.5% of the individuals were men. The mean daily average over 10 years of airborne THC concentration was 2.25 ppm (SD 0.13), and NMHC was 0.29 ppm (SD 0.09). Both pollutants show long-term monotonic downward trend over time using the Mann–Kendall test. There was a dose-dependent increase in UBC at follow-up. UBC incidence per 100,000 enrollees according to T1/T2/T3 exposure to THC was 60.9, 221.2, and 651.8, respectively; it was 170.0/349.5/426.7 per 100,000 enrollees, corresponding to T1/T2/T3 exposure to NMHC, respectively. Without controlling for confounding air pollutants, the adjusted hazard ratio (adj.HR) was 1.83 (95% CI 1.75–1.91) per 0.13-ppm increase in THC; after controlling for PM2.5, adj.HR was even higher at 2.09 (95% CI 1.99–2.19). The adj.HR was 1.37 (95% CI 1.32–1.43) per 0.09-ppm increase in ambient NMHC concentration. After controlling for SO2 and CH4, the adj.HR was 1.10 (95% CI 1.06–1.15). Sensitivity analyses showed that UBC development risk was not sex-specific or influenced by diabetes status. Long-term exposure to THC and NMHC may be a risk factor for UBC development. Acknowledging pollutant sources can inform risk management strategies.

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Section: Methodsmentioning

confidence: 99%

Long-term ambient hydrocarbon exposure and incidence of urinary bladder cancer

Zhang

Tsai

Kok

et al. 2022

Sci Rep

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“…Previous studies have shown that there are sex‐specific differences in UTUC, with the prevalence of UTUC being approximately twice as high in males than in females in the United States and Western European 7,10,11 . In contrast, a 2001–2010 Taiwanese study showed that the annual incidence of UTUC in women was significantly higher than that in men (female to male ratio: 2.08–3.25) 9 . Relevant studies conducted in recent years have determined that the carcinogenic mechanisms of UTUC are related to smoking, exposure to aristolochic acid, genetic predisposition, and environmental factors 12,13 .…”

Section: Introductionmentioning

confidence: 97%

“…However, compared with those in other countries, the incidence of upper tract urothelial cancer (UTUC) in Taiwan is abnormally high, especially in women 2–6 . The annual incidence of UTUC is 1–2 cases per 100,000 people worldwide, but it is 3.14–3.41 in Taiwan 7–9 . Previous studies have shown that there are sex‐specific differences in UTUC, with the prevalence of UTUC being approximately twice as high in males than in females in the United States and Western European 7,10,11 .…”

Section: Introductionmentioning

confidence: 99%

Trends and sex‐specific incidence of upper urinary tract cancer in Taiwan: A birth cohort study

et al. 2023

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BackgroundTaiwan has one of the highest incidences of upper tract urothelial cancer (UTUC) worldwide, especially in women; however, no nationwide, long‐term follow‐up study has evaluated this.MethodsWe investigated the incidence of UTUC in Taiwan using data from the national population‐based Taiwan Cancer Registry database (1985–2019). We divided the birth cohort into nine 5‐year age groups and calculated the age‐specific incidence for these groups according to the corresponding birth years.ResultsThe average annual percent change in the incidence of renal pelvis cancer from 1985 to 2019 showed sex‐specific differences, with 3.5% and 5.3% increases in the incidences in men and women, respectively. The age‐specific incidence rate for renal pelvis cancer among women showed a gradual increase in the group with older women as well as an increase over time in each age group. The results of a birth cohort analysis revealed that younger cohorts had higher incidence rates of renal pelvis cancer than older cohorts did.ConclusionWe demonstrated that the incidence of UTUC is unusually high among older Taiwanese women and that younger cohorts have a high risk of UTUC than older cohorts.

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“…Another relatively rare type of UC called upper tract urothelial carcinoma (UTUC) that accounts for 5%-10% of UC is located in the renal pelvis and ureter (3). The annual incidence of UTUC ranges from 1.2 to 4.7 cases per 100,000 inhabitants and also frequently occurs in men globally (4). In contrast, UTUC has an unusually high incidence that accounts for 40% of UC in Taiwan (5).…”

Section: Introductionmentioning

confidence: 99%

The biological impacts of CEBPD on urothelial carcinoma development and progression

Chan

Shiue

2023

Front. Oncol.

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Urothelial carcinoma (UC), which includes urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC), is one of the most common malignancies worldwide. Accordingly, a comprehensive understanding of the underlying mechanism governing UC development is compulsory. Aberrant CCAAT/enhancer-binding protein delta (CEBPD), a transcription factor, displays an oncogene or tumor suppressor depending on tumor type and microenvironments. However, CEBPD has been reported to possess a clear oncogenic function in UC through multiple regulation pathways. Genomic amplification of CEBPD triggered by MYC-driven genome instability is frequently examined in UC that drives CEBPD overexpression. Upregulated CEBPD transcriptionally suppresses FBXW7 to stabilize MYC protein and further induces hexokinase II (HK2)-related aerobic glycolysis that fuels cell growth. Apart from the MYC-dependent pathway, CEBPD also downregulates the level of hsa-miR-429 to enhance HK2-associated glycolysis and induce angiogenesis driven by vascular endothelial growth factor A (VEGFA). Additionally, aggressive UC is attributed to the tumor metastasis regulated by CEBPD-induced matrix metalloproteinase-2 (MMP2) overexpression. Furthermore, elevated CEBPD induced by cisplatin (CDDP) is identified to have dual functions, namely, CDDP-induced chemotherapy resistance or drive CDDP-induced antitumorigenesis. Given that the role of CEBPD in UC is getting clear but pending a more systemic reappraisal, this review aimed to comprehensively discuss the underlying mechanism of CEBPD in UC tumorigenesis.

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Incidence and survival variations of upper tract urothelial cancer in Taiwan (2001–2010)

Cited by 10 publications

References 25 publications

Long-term ambient hydrocarbon exposure and incidence of urinary bladder cancer

Long-term ambient hydrocarbon exposure and incidence of urinary bladder cancer

Trends and sex‐specific incidence of upper urinary tract cancer in Taiwan: A birth cohort study

The biological impacts of CEBPD on urothelial carcinoma development and progression

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