Incidence and survival of uveal melanoma in Northern Ireland: how incomplete data can skew results in rare cancers

Quhill, Hibba; Jefferis, Joanna M; Rennie, I G; Salvi, Sachin M.; Gavin, Anna; Fitzpatrick, Deirdre; Savage, Gerard; Curragh, David; Rundle, Paul

doi:10.1038/s41433-022-02352-4

Cited by 1 publication

(2 citation statements)

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“…The incidence rates and trends of UM vary among countries owing to different risk factors and population structures [ 12 ]. Our incidence rates are consistent with those of previous reports on the incidence of UM: 9.6 cases/million between 1960 and 2009 in Sweden [ 24 ], 6.4 cases/million between 2011 and 2017 in Canada [ 12 ], 6.4 cases/million between 2009 and 2015 in Germany [ 13 ], 6.7 cases/million between 1988 and 2007 in Israel [ 10 ], 7.0 cases/million between 1994 and 2008 in Scotland [ 25 ], 7.4 cases/million between 1943 and 1952 in Denmark [ 8 ], 6.1–7.6 cases/million between 1982 and 2014 in Australia [ 26 , 27 ], 8.6 cases/million in 2016 in Northern Ireland [ 28 ], 9 cases/million between 1953 and 1960 in Norway [ 29 ], 9.5 cases/million between 2010 and 2015 in Ireland [ 30 ], 10.0 cases/million between 1999 and 2010 in England [ 15 ]. However, the Hungarian incidence rates were higher than those in South Korea between 1999 and 2011 (0.4 cases/million) [ 31 ], China between 1990 and 2005 (0.6 cases/million), Japan between 2011 and 2013 (0.64 cases/million) [ 7 ], Brazil between 2010 and 2015 (4.6 cases/million) [ 16 ], the USA between 1973 and 2008 (5.1 cases/million) [ 11 ], and the USA between 2010 and 2015 (4.6 cases/million) [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, nitric oxide synthase expression is associated with poor prognosis and reduced survival in UM [ 49 ]. Despite improvements in treatment options, five-year disease-specific survival remains unchanged, as reported in the USA (80.9%) between 1973 and 2013 [ 50 ], Australia (81%) between 1982 and 2015 [ 27 ], Northern Ireland (82.6%) in 2016 [ 28 ], and China (86.6%) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

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Incidence and Mortality of Uveal Melanoma in Hungary: A Nationwide Study

Tóth,

Muzsik,

Szajkó

et al. 2024

Cancers

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Uveal melanoma (UM) is the most common primary malignant ocular tumour in adults, although its epidemiology in Central and Eastern Europe is unclear. This study aimed to analyse the incidence and all-cause mortality of UM in Hungary. This nationwide, retrospective, longitudinal study used data from the National Health Insurance Fund and included patients aged ≥18 years who were newly diagnosed with UM (ICD-10 C69.3 or C69.4) between 1 January 2012 and 31 December 2021. Age-standardised incidence and all-cause mortality rates were calculated using European Standard Population data from 2013. We identified 88 and 70 new patients with UM in 2012 and 2021, respectively, showing an almost stable trend. Age-standardised incidence rates varied between 6.40 and 10.96/1,000,000 person-years (PYs) during the analysed period. The highest age-standardised incidence was detected among men (13.38/1,000,000 PYs) in 2015. All-cause mortality decreased from 4.72/1,000,000 PYs to 0.79/1,000,000 PYs between 2012 and 2021. In conclusion, the UM incidence rate in Hungary is comparable to European incidence rates. The incidence did not markedly change, whereas all-cause mortality decreased during the study period, but this decline could not be attributed to improved treatment modalities for primary tumours and metastatic UM.

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