Incidence and survival of rare urogenital cancers in Europe

Visser, Otto; Adolfsson, Jan; Rossi, Silvia; Verne, Julia; Gatta, Gemma; Maffezzini, Massimo; Franks, K.

doi:10.1016/j.ejca.2011.10.031

Cited by 148 publications

(96 citation statements)

References 31 publications

(31 reference statements)

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“…Los carcinomas uroteliales del TUS son tumores poco frecuentes, (menos del 5-10%) entre todos los tumores uroteliales, con una tasa de incidencia de 1.45-2.06 casos por cada 100.000 personas-año, presentando un pico en la octava década de la vida (6,7,8).…”

Section: Discussionunclassified

Descriptive analysis of a series of 32 upper urinary tract tumors in a second level hospital

et al. 2014

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Análisis descriptivo de una serie de 32 tumores del tracto urinario superior en un hospital de segundo nivel ResumenIntroducción: El objetivo del estudio es analizar, basándonos en los pacientes tratados en nuestro servicio de tumores del tracto urinario superior, las características epidemiológicas y clínicas así como las variables que han influido en la evolución y mortalidad de estos pacientes. Materiales y Métodos: Se analizaron retrospectivamente 32 pacientes diagnosticados de tumores del tracto urinario superior en el Hospital comarcal Santa Ana de Motril (Granada), en el periodo comprendido entre enero del 2003 y diciembre del 2013. Resultados: La edad media fue de 72,25 años. El 75% eran hombres y el 25% mujeres. El 71.9% eran hipertensos, el 46.9% fumadores. El 18.8% presentaba un tumor vesical en el momento del diagnóstico. El 90.6% debutó con hematuria. El 53.1% se localizó en el lado derecho y el 43.8% en el izquierdo. El 25% se desarrollaron en los cálices, el 46.8% en la pelvis renal y el 50% a nivel ureteral. El estadio anatomopatológico al diagnóstico fue: 6.3% Ta, 25% T1, 28.1% T2, 37.5% T3 y 3.1% T4. El 21.9% eran grado I, el 34.4% grado II y el 43.8% grado III. No se observó recidiva tumoral en ningún paciente, siendo la mortalidad cáncer -específica del 0%. En 8 pacientes se diagnosticó un tumor vesical durante su seguimiento. La media de estancia hospitalaria fue de 7 días. Conclusiones: A pesar de ser una casuística limitada los resultados obtenidos son satisfactorios independientemente de la técnica quirúrgica empleada, al ser la supervivencia libre de enfermedad en el periodo de seguimiento del 100% y la mortalidad cáncer-específica del 0%. AbstractIntroduction: The aim of the study is to analyze, based on patients treated in our department of upper urinary tract tumors, epidemiological and clinical characteristics as well as the variables that have influenced the evolution and mortality of these patients Material and methods: 32 patients diagnosed of upper urinary tract tumors in Santa Ana Hospital of Motril (Granada) between January 2003 and December 2013 were retrospectively analyzed. Results: The mean age was 72.25 years. 75% were male and 25% female. 71.9% were hypertensive, 46.9% were smokers. 18.8% had a bladder tumor at diagnosis. 90.6% debuted with hematuria.53.1% was located on the right side and 43.8% on the left. 25% were developed in the chalices, 46.8% in the renal pelvis and ureteral 50%.The pathologic stage at diagnosis: 6.3% Ta, 25% T1, 28.1% T2, 37.5% T3 and 3.1% T4. 21.9% were grade I, grade II 34.4% and 43.8% grade III. No tumor recurrence was observed in any patient being cancer -specific mortality of 0%. In 8 patients bladder tumor was diagnosed during follow-up. The mean hospital stay was 7 days. Conclusions: Despite being limited casuistry the results are satisfactory regardless of the surgical technique used, being disease-free survival in the follow-up period of 100% and cancer-specific mortality of 0%. Enviado: 02-12-2014 Revisado: 22-12-2014 Aceptado: 29-12-...

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Section: Discussionunclassified

Descriptive analysis of a series of 32 upper urinary tract tumors in a second level hospital

et al. 2014

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“…Therefore, combining all these cases into one group carries important limitations. However, population-based studies have shown that the histological subtype of urethral carcinoma does not appear to exert an impact on prognosis [1,2,8,9] . Nonetheless, it has to be acknowledged that urethral cancer is a rare disease for which therapeutic strategies still need to be better defined [12] .…”

Section: Discussionmentioning

confidence: 99%

“…It accounts for well under 1% of all malignancies, with an estimated incidence of 650 new cases per year and an age-standardized ratio of approximately 2-5 per million in men and 0.6-2 per million in women [1,2] .…”

Section: Introductionmentioning

confidence: 99%

Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

et al. 2016

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chronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020). Conclusion: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach. © 2016 S. Karger AG, Basel Key WordsBladder cancer · Lymph node · Prognosis · Radical cystectomy · Risk factor · Survival · Urethra Abstract Introduction: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma. Methods: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence. Results: Syn-

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“…Generally, UCs are seen in the 5th decade. 1,2 Patients presented with non-specific and overlapping clinical signs and symptoms. 1,3 Management of UC is still controversial and challenging due to lack of experience.…”

Section: Introductionmentioning

confidence: 99%

Primary squamous cell carcinoma of the urethral diverticulum mimicking prostate cancer: Case report and review of the literature

Ekin¹,

Yıldırım²,

Bayol³

et al. 2015

CUAJ

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Primary urethral carcinomas are uncommon, with urothelial carcinoma as the most common subtype. Urethral diverticulum is also rarely seen in men. A 44-year-old male presented with voiding symptoms. Abdominoperineal resection, prostatectomy, bladder neck excision, and proximal urethral excision were performed. A pathological examination revealed a well-differentiated squamous cell carcinoma (SCC) located inside an urethral diverticulum. We report this unusual case because primary SCC of the male urethral diverticulum is extremely rare. To our knowledge, our patient is only the second reported case. IntroductionPrimary urethral carcinoma (UC) is rare and accounts for less than 1% of all cancers.1,2 UC is the most common subtype. Generally, UCs are seen in the 5th decade.1,2 Patients presented with non-specific and overlapping clinical signs and symptoms.1,3 Management of UC is still controversial and challenging due to lack of experience.3 The surgical approach depends on the location and extent of the tumour. In advanced urethral squamous cell carcinoma (SCC), a combination of surgery, radiotherapy, and chemotherapy is recommended.3-6 The 5-year overall survival in patients with UC is about 50% to 55%. 2,3,5 Case reportA 44-year-old male presented with voiding difficulty and constipation for 3 months. He had a history of right nephrectomy for non-functional kidney secondary to a kidney stone. Although digital rectal examination revealed a hard, fixed mass on the anterior rectal wall, his prostate-specific antigen level was 0.61 ng/mL. A transrectal prostate biopsy was performed, and the pathological examination revealed a welldifferentiated SCC. The patient was referred to our urology clinic with a preliminary diagnosis of primary SCC of the prostate. A magnetic resonance imaging (MRI) showed a 6 × 7.2 × 8.1-cm round mass with smooth margins and heterogeneous internal enhancement. The mass abutted the rectum and bladder, and extended to the apex of the prostate and the levator ani without sign of invasion (Fig. 1). The prostate and lymph nodes were normal. For the purpose of a differential diagnosis, a colonoscopy was performed and the mucosa was normal. The patient underwent a cystourethroscopy and biopsy under anesthesia. We demonstrated a large wide-mouthed urethral diverticulum and tumour growth in the bulbomembranous urethral diverticulum. The prostate was normal and the dimensions of the prostate were compatible with the patient's age. The bladder mucosa was intact, with external tumour compression. A histopathologic examination revealed a well-differentiated SCC with an inverted and warty growth pattern, keratinization with keratin pearl and dyskeratotic cells.The patient was informed about the radical cystoprostatectomy and abdominoperineal resection if organ preservation was unfavourable, and informed consent was obtained. Abdominoperineal resection, prostatectomy, bladder neck excision, and proximal urethral excision were performed. On gross examination of the excision specimen, there was the pr...

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Incidence and survival of rare urogenital cancers in Europe

Cited by 148 publications

References 31 publications

Descriptive analysis of a series of 32 upper urinary tract tumors in a second level hospital

Descriptive analysis of a series of 32 upper urinary tract tumors in a second level hospital

Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

Primary squamous cell carcinoma of the urethral diverticulum mimicking prostate cancer: Case report and review of the literature

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