Incidence and survival in late liver metastases of colorectal cancer

Landreau, Pierre; Drouillard, Antoine; Launoy, Guy; Ortega‐Deballon, Pablo; Jooste, Valérie; Lepage, Côme; Faivre, Jean; Facy, Olivier; Bouvier, Anne–Marie

doi:10.1111/jgh.12685

Cited by 69 publications

(53 citation statements)

References 15 publications

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“…Patients with metachronous tumours treated 1⋅54-7⋅12 years after diagnosis had a better prognosis, in accordance with other reports 47 . Patients with metastases that were treated surgically 0⋅76-1⋅54 years after diagnosis of the primary tumour had the worst outcome.…”

Section: Discussionsupporting

confidence: 91%

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

et al. 2020

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Background: Resection of the primary tumour is a prerequisite for cure in patients with colorectal cancer, but hepatic metastasectomy has been used increasingly with curative intent. This national registry study examined prognostic factors for radically treated primary tumours, including the subgroup of patients undergoing liver metastasectomy. Methods: Patients who had radical resection of primary colorectal cancer in 2009-2013 were identified in a population-based Swedish colorectal registry and cross-checked in a registry of liver tumours. Data on primary tumour and patient characteristics were extracted and prognostic impact was analysed.Results: Radical resection was registered in 20 853 patients; in 38⋅7 per cent of those registered with liver metastases, surgery or ablation was performed. The age-standardized relative 5-year survival rate after radical resection of colorectal cancer was 80⋅9 (95 per cent c.i. 80⋅2 to 81⋅6) per cent, and the rate after surgery for colorectal liver metastases was 49⋅6 (46⋅0 to 53⋅2) per cent. Multivariable analysis identified lymph node status, multiple sites of metastasis, high ASA grade and postoperative complications after resection of the primary tumour as strong risk factors after primary resection and following subsequent liver resection or ablation. Age, sex and primary tumour location had no prognostic impact on mortality after liver resection.Conclusion: Lymph node status and complications have a negative impact on outcome after both primary resection and liver surgery. Older age and female sex were underrepresented in the liver surgical cohort, but these factors did not influence prognosis significantly.

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Section: Discussionsupporting

confidence: 91%

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

et al. 2020

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“…Patients with many types of cancer are at high risk of liver metastases. Moreover, tumors originating from intra‐abdominal organs, such as those of the stomach, pancreas, colon, gallbladder, bile duct, and ovary, often exhibit both peritoneal dissemination and liver metastasis . Together with the findings of our previous study , the results obtained in this study suggest that the i.p.…”

Section: Discussionsupporting

confidence: 85%

Therapy of primary and metastatic liver cancer by human iPS cell‐derived myeloid cells producing interferon‐β

Sakisaka

Haruta

Komohara

et al. 2017

J Hepato Biliary Pancreat

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“…The selection criteria for surgery have expanded, and patients with limited concomitant extrahepatic disease are now also offered surgery. Several region‐based studies have published resection rates for CLM, with values between 6 and 35 per cent. Three nationwide studies have been conducted in recent years.…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer is the second most common malignancy in Norway with approximately 4000 patients diagnosed annually. A substantial proportion of patients with colorectal cancer (15–29 per cent) develop colorectal liver metastases (CLM), and surgery is the only treatment with curative intent. Improvements in surgical technique, better insight into the biology of the disease, and the development of potent chemotherapeutic and targeted drugs have expanded the indications for surgery.…”

Section: Introductionmentioning

confidence: 99%

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Population-based study on resection rates and survival in patients with colorectal liver metastasis in Norway

Angelsen

Horn

Sørbye

et al. 2017

British Journal of Surgery

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Incidence and survival in late liver metastases of colorectal cancer

Abstract: Liver metastases from colorectal cancer remain a substantial problem and continue to occur long after five years. This study furnishes unbiased figures that can be used as a reference. Liver metastases that appear late have a better prognosis.

Cited by 69 publications

References 15 publications

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

Therapy of primary and metastatic liver cancer by human iPS cell‐derived myeloid cells producing interferon‐β

Population-based study on resection rates and survival in patients with colorectal liver metastasis in Norway

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