Incidence and severity prediction score of COVID-19 in people living with HIV (SCOVHIV): experience from the first and second waves of the pandemic in Indonesia

Yunihastuti, Evy; Karjadi, Teguh Harjono; Widhani, Alvina; Mahdi, Haridana Indah Setiawati; Sundari, Salma; Hapsari, Aljira Fitya; Koesnoe, Sukamto; Djauzi, Samsuridjal

doi:10.1186/s12981-022-00472-1

Cited by 3 publications

(1 citation statement)

References 30 publications

(57 reference statements)

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“…However, our previous study found that PLHIV do have an understanding that they are more susceptible to COVID-19 infection. [ 26 ] A recent study reported that mortality and severity of COVID-19 were higher in PLHIV with lower CD4 counts [ 27 ]. In the current study, most patients had high CD4 counts.…”

Section: Discussionmentioning

confidence: 99%

Predicting Intention to Receive COVID-19 Vaccination in People Living with HIV using an Integrated Behavior Model

et al. 2023

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People living with HIV (PLHIV) are considered a high-risk population for developing a severe form of COVID-19. Vaccination is still one of the most important modalities in combating the disease due to the lack of an effective treatment. This multicenter study was performed from September to December 2021 with the aim to analyze the intention of PLHIV to receive the COVID-19 vaccination based on an integrated behavior model (IBM) in Indonesia. Of a total of 470 participants, 75.6% of patients were intent to be vaccinated. The model that was designed in this study explains 43.4% of the variance in intention to be vaccinated against COVID-19 in PLHIV (adjusted R2 = 0.434). Furthermore, the determinants used included instrumental attitude (β = 0.127, p < 0.05), subjective norm (β = 0.497, p < 0.01), and perceived behavioral control (β = 0.116, p < 0.01). This study concluded that an IBM could predict the intention of PLHIV to receive COVID-19 vaccination.

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Section: Discussionmentioning

confidence: 99%

Predicting Intention to Receive COVID-19 Vaccination in People Living with HIV using an Integrated Behavior Model

et al. 2023

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A novel application of Kier–Hall electrotopological descriptors in datamining new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the basis of chemical similarity

Gupta¹,

Jain

Sule³

et al. 2023

J Math Chem

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Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV

Amegashie,

Asamoah,

Ativi

et al. 2024

Exp. Biol. Med.

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People living with HIV (PLWH) usually suffer from co-infections and co-morbidities including respiratory tract infections. SARS-CoV-2 has been reported to cause respiratory infections. There are uncertainties in the disease severity and immunological response among PLWH who are co-infected with COVID-19. This review outlines the current knowledge on the clinical outcomes and immunological response to SARS-CoV-2 among PLWH. Literature was searched in Google scholar, Scopus, PubMed, and Science Direct conforming with the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines from studies published from January 2020 to June 2023. A total of 81 studies from 25 countries were identified, and RT-PCR was used in confirming COVID-19 in 80 of the studies. Fifty-seven studies assessed risk factors and clinical outcomes in HIV patients co-infected with COVID-19. Thirty-nine of the studies indicated the following factors being associated with severe outcomes in HIV/SARS-CoV-2: older age, the male sex, African American race, smoking, obesity, cardiovascular diseases, low CD4+ count, high viral load, tuberculosis, high levels of inflammatory markers, chronic kidney disease, hypertension, diabetes, interruption, and delayed initiation of ART. The severe outcomes are patients’ hospitalization, admission at intensive care unit, mechanical ventilation, and death. Twenty (20) studies, however, reported no difference in clinical presentation among co-infected compared to mono-infected individuals. Immune response to SARS-CoV-2 infection was investigated in 25 studies, with some of the studies reporting high levels of inflammatory markers, T cell exhaustion and lower positive conversion rate of IgG in PLWH. There is scanty information on the cytokines that predisposes to severity among HIV/SARS-CoV-2 co-infected individuals on combined ART. More research work should be carried out to validate co-infection-related cytokines and/or immune markers to SARS-CoV-2 among PLWH.

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Incidence and severity prediction score of COVID-19 in people living with HIV (SCOVHIV): experience from the first and second waves of the pandemic in Indonesia

Cited by 3 publications

References 30 publications

Predicting Intention to Receive COVID-19 Vaccination in People Living with HIV using an Integrated Behavior Model

Predicting Intention to Receive COVID-19 Vaccination in People Living with HIV using an Integrated Behavior Model

A novel application of Kier–Hall electrotopological descriptors in datamining new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the basis of chemical similarity

Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV

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