Incidence and severity of retinopathy of prematurity in extremely premature infants

Isaza, Gloria; Arora, Sourabh

doi:10.1016/j.jcjo.2012.03.027

Cited by 34 publications

(33 citation statements)

References 23 publications

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“…In developing countries, infants who develop ROP are larger and of a greater estimated GA than those in developed countries 8 23. In a Canadian study, no infant with BW >1250 g developed ≥stage 3 ROP, and no infant born at GA >26 weeks and BW >1000 g developed type 1 ROP 24. In the present study, 41 neonates with BW >1500 g and three babies with BW >2001 g underwent laser photocoagulation therapy.…”

Section: Discussionmentioning

confidence: 47%

Incidence and severity of retinopathy of prematurity in Turkey

2015

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Section: Discussionmentioning

confidence: 47%

Incidence and severity of retinopathy of prematurity in Turkey

2015

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“…Mean gestational age at birth was 28.34±1.91 weeks in the infants without ROP vs. 26.65±1.84 weeks in those with ROP. When the patients in the present study were divided into 2 subgroups according to gestational age at birth (≤25 weeks vs. ≥26 weeks), 90% (45/50) of the ELBW infants delivered at ≤25 weeks developed ROP vs. 88% in a study by Isaza et al [6] and 87% in a study by Teed et al [35]. These similar percentages are in agreement with the general knowledge that prematurity plays an important role in the pathogenesis of ROP [34,36–42].…”

Section: Discussionmentioning

confidence: 78%

“…Fortes et al reported that 48.9% of ELBW infants in southern Brazil developed threshold ROP requiring laser treatment [19]; however, a study conducted in China [31] reported that the incidence of ROP requiring laser treatment was 28.6%, in contrast to 28.7% in a study of ELBW infants conducted in the USA [32]. A Canadian study reported that the overall incidence of stage ≥3 ROP in ELBW infants was 17.3% [6]. The lowest incidence of ROP requiring laser treatment in ELBW infants was reported from Brazil (12.7%) [33].…”

Section: Discussionmentioning

confidence: 99%

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The Incidence and Risk Factors of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants in Turkey

et al. 2014

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BackgroundThe aim of this study was to identify the incidence of severe retinopathy of prematurity (ROP) requiring laser treatment and the overall incidence of ROP in extremely low birth weight (ELBW) infants, and to evaluate the associated risk factors for developing severe ROP in ELBW infants in Turkey.Material/MethodsThis retrospective, case-control, tertiary care-hospital based study included 235 ELBW infants screened for ROP. The incidence of the onset of ROP and severe ROP requiring laser treatment were assessed. The relationship between various clinical risk factors, and the development of severe ROP and onset of ROP were analyzed using univariate analysis and multivariate logistic regression analysis.ResultsThe overall incidence of any stage ROP and severe ROP requiring laser treatment in ELBW infants was 75.5% and 38.7%, respectively. Severe ROP requiring laser treatment in ELBW infants was significantly associated with various independent risk factors, including blood transfusion (P=0.002), gestational age at birth (P<0.001), gestational weight at birth (P=0.001), culture-proven sepsis (P=0.047).ConclusionsThe severity of ROP may increase as weight at birth and gestational age at birth decrease, and in those with culture-proven sepsis as well as in those that receive blood transfusion. Clinicians should be aware of the presence of these risk factors when treating ELBW premature infants. Early detection and prevention of sepsis and reducing the number of blood transfusions may decrease the incidence of severe ROP requiring laser treatment.

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“…22 These effects are most obvious in the neonate developing retrolental hyperplasia after exposure to high oxygen concentrations. 23 However, it could conceptually occur in many other organ systems in both the infant and the adult. This is not a well studied area, but there is evidence in the cardiology literature that routine use of supplemental O 2 in patients with acute myocardial infarction who are not hypoxemic may worsen outcomes.…”

Section: Oxygen Toxicitymentioning

confidence: 99%

Supporting Oxygenation in Acute Respiratory Failure

MacIntyre

2012

Respir Care

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SummaryStrategies to support oxygenation can cause substantial harm through lung stretch injury, oxygen toxicity, transfusion risks and cardiac over-stimulation. Traditional goals of maintaining near normal cardiorespiratory parameters are most likely overly simplistic and are insensitive and nonspecific for tissue hypoxic effects. In order to reduce iatrogenic harm, it is conceivable that clinicians could be comfortable with lower levels of arterial oxygen content (eg, oxyhemoglobin values of < 88%: so called "permissive hypoxemia"), provided that there are ways to effectively monitor tissue hypoxia. We can learn more about hypoxic compensatory mechanisms from the fetus and from high altitude residents. We also need to learn better ways of monitoring tissue oxygenation, especially in "mission critical" tissues. Ultimately clinical trials will be needed to determine appropriate oxygenation targets to allow permissive hypoxemia.

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Incidence and severity of retinopathy of prematurity in extremely premature infants

Cited by 34 publications

References 23 publications

Incidence and severity of retinopathy of prematurity in Turkey

Incidence and severity of retinopathy of prematurity in Turkey

The Incidence and Risk Factors of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants in Turkey

Supporting Oxygenation in Acute Respiratory Failure

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