Incidence and Risk of Suicide Among Patients With Head and Neck Cancer in Rural, Urban, and Metropolitan Areas

Osazuwa‐Peters, Nosayaba; Barnes, Justin M.; Okafor, Somtochi I; Taylor, Derian B.; Hussaini, Adnan S.; Boakye, Eric Adjei; Simpson, Matthew C.; Graboyes, Evan M.; Lee, Walter T.

doi:10.1001/jamaoto.2021.1728

Cited by 28 publications

(15 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study also adds to the growing literature on suicide risk in HNC. We found that suicide rates in HPV-related and non–HPV-related HNC were higher than those of the general population, which supports findings from other studies that have examined incidence of suicide in HNC . Factors associated with suicide risk in the current study included being male, White, and unmarried and lack of treatment, as previously described .…”

Section: Discussionsupporting

confidence: 91%

Association of Human Papillomavirus Status With Suicide Risk Among Patients With Head and Neck Cancer

Chakoma

Moon

Osazuwa‐Peters

et al. 2023

JAMA Otolaryngol Head Neck Surg

Self Cite

View full text Add to dashboard Cite

ImportanceHuman papillomavirus (HPV) is strongly associated with head and neck cancer, and HPV status is considered a prognostic factor. Being a sexually transmitted infection, HPV-related cancers may have greater risk of stigma and psychological distress; however, the potential association of HPV-positive status with psychosocial outcomes, such as suicide, is understudied in head and neck cancer.ObjectiveTo investigate the association between HPV tumor status and suicide risk among patients with head and neck cancer.Design, Setting, and ParticipantsThis population-based retrospective cohort study included adult patients with clinically confirmed cases of head and neck cancer based on HPV tumor status from the Surveillance, Epidemiology, and End Results database from January 1, 2000, to December 31, 2018. Data analysis was conducted from February 1 to July 22, 2022.Main Outcomes and MeasuresThe outcome of interest was death by suicide. Primary measure was HPV status of tumor site, dichotomized as positive or negative. Covariates included age, race, ethnicity, marital status, cancer stage at presentation, treatment modality, and type of residence. Cumulative risk of suicide among patients with HPV-positive and HPV-negative head and neck cancer was assessed using Fine and Gray competing risk models.ResultsOf 60 361 participants, the mean (SD) age was 61.2 (13.65) years, and 17 036 (28.2%) were women; there were 347 (0.6%) American Indian, 4369 (7.2%) Asian, 5226 (8.7%) Black, 414 (0.7%) Native Hawaiian or Other Pacific Islander, and 49 187 (81.5%) White individuals. A competing risk analysis showed a significant difference in the cumulative incidence of suicide between HPV-positive cancers (5-year suicide-specific mortality, 0.43%; 95% CI, 0.33%-0.55%) and HPV-negative cancers (5-year suicide-specific mortality, 0.24%; 95% CI, 0.19%-0.29%). Tumor status that was HPV positive was associated with increased suicide risk in the unadjusted model (hazard ratio [HR], 1.76; 95% CI, 1.28-2.40), but not the fully adjusted model (adjusted HR, 1.18; 95% CI, 0.79-1.79). Among people with oropharyngeal cancer only, HPV status was associated with increased suicide risk, but the width of the confidence interval prevented definitive conclusion (adjusted HR, 1.61; 95% CI 0.88-2.94).Conclusions and RelevanceThe results of this cohort study suggest that patients with HPV-positive head and neck cancer have similar risk of suicide as patients with HPV-negative cancer, despite differences in overall prognosis. Early mental health interventions may be associated with reduced suicide risk in all patients with head and neck cancer and should be assessed in future work.

show abstract

Section: Discussionsupporting

confidence: 91%

Association of Human Papillomavirus Status With Suicide Risk Among Patients With Head and Neck Cancer

Chakoma

Moon

Osazuwa‐Peters

et al. 2023

JAMA Otolaryngol Head Neck Surg

Self Cite

View full text Add to dashboard Cite

show abstract

“…Scheduled and opportunistic screening by appropriately trained individuals is highly recommended for targeted populations [ 44 ]. In addition, the unknown prognosis of diagnosed oncological disease causes patients’ anxiety, consequently, the suicide mortality rate among patients with head and neck cancer is high–59, 64, and 127 per 100 000 person-years among residents of metropolitan, urban, and rural counties, respectively [ 45 ]. Therefore, a brief psychosocial screening protocol should be implemented in routine ambulatory oncology care as 57% of HNSCC patients were identified with clinical distress [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

The survival rate of laryngeal squamous cell carcinoma: impact of IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, BLK rs13277113, and TIMP3 rs9621532 single nucleotide polymorphisms

et al. 2023

View full text Add to dashboard Cite

Purpose Results of laryngeal squamous cell carcinoma (LSCC) treatment and the 5 year survival rate of these patients remain poor. To purify therapeutic targets, investigation of new specific and prognostic blood-based markers for LSCC development is essential. Methods In the present study, we evaluated five single nucleotide polymorphisms (SNPs): IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, BLK rs13277113, and TIMP3 rs9621532, and determined their associations with the patients’ 5 year survival rate. Also, we performed a detailed statistical analysis of different LSCC patients’ characteristics impact on their survival rate. Results Three hundred fifty-three LSCC patients and 538 control subjects were included in this study. The multivariable Cox regression analysis revealed a significant association between patients’ survival rate and distribution of IL1RAP rs4624606 variants: patients carrying AT genotype at IL1RAP rs4624606 had a lower risk of death (p = 0.044). Also, it was revealed that tumor size (T) (p = 0.000), tumor differentiation grade (G) (p = 0.015), and IL1RAP rs4624606 genotype (p = 0.044) were effective variables in multivariable Cox regression analysis prognosing survival of LSCC patients. The specific-LSCC 5 year survival rate was 77%. Conclusions In summary, our findings indicate that the genotypic distribution of IL1RAP rs4624606 influences the 5 year survival rate of LSCC patients. The results of the present study facilitate a more complete understanding of LSCC at the biological level, thus providing the base for the identification of new specific and prognostic blood-based markers for LSCC development.

show abstract

“…Most suicides occurring in those over the age of 60 years are related to an underlying medical illness [25]. Several groups have established that patients with cancer are at increased risk of suicide [26][27][28][29]. Suicide, however, is just one manifestation of distress.…”

Section: Suicide and Self-harmmentioning

confidence: 99%

“…Body image-related distress is a disorder characterized by a distressing self-perceived change in appearance and function [44,45]. It can lead to social isolation, stigmatization, depression, and self-harm [26,46]. A 24-item disease-specific patient-reported outcome was recently created to assess body image distress among head and neck cancer patients – The Inventory to Measure and Assess Image Disturbance – Head and Neck (IMAGE-HN) [47 ▪▪ ,48].…”

Section: Screening For Emotional Distress Through Patient-reported Ou...mentioning

confidence: 99%

Mental health considerations in patients undergoing complex head and neck reconstruction

Philteos

Noel

Hallet

et al. 2022

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

View full text Add to dashboard Cite

Purpose of reviewTo summarize recent advances in the psycho-oncology literature, with a focus on findings relevant to the head and neck cancer patient. Recent findingsPatients with cancer are at an increased risk of suicide and self-harm. Head and neck cancer patients are among the highest risk compared with other cancer patients. Unique challenges pertaining to disfigurement and voicelessness may, in part, explain these observations. Patient-reported outcome measures can be used to help identify high-risk patients.

show abstract

Incidence and Risk of Suicide Among Patients With Head and Neck Cancer in Rural, Urban, and Metropolitan Areas

Cited by 28 publications

References 66 publications

Association of Human Papillomavirus Status With Suicide Risk Among Patients With Head and Neck Cancer

Association of Human Papillomavirus Status With Suicide Risk Among Patients With Head and Neck Cancer

The survival rate of laryngeal squamous cell carcinoma: impact of IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, BLK rs13277113, and TIMP3 rs9621532 single nucleotide polymorphisms

Mental health considerations in patients undergoing complex head and neck reconstruction

Contact Info

Product

Resources

About