Incidence and Risk of Lung Cancer in Tuberculosis Patients, and Vice Versa: A Literature Review of the Last Decade

Bhowmik, Sutapa; Mohanto, Nayan Chandra; Sarker, Dipanjon; Sorove, Asma Ahsan

doi:10.1155/2022/1702819

Cited by 5 publications

(3 citation statements)

References 69 publications

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“…Analysis of the clinical characteristics of patients with LC-PTB and its subgroups, LC-APTB and LC-IPTB, revealed key ndings. Firstly, demographic characteristics showed that the median age of the LC-PTB group was 64 years, with a predominance of males and a widespread history of smoking, consistent with the literature suggesting that lung cancer with concurrent tuberculosis is common in older males who smoke [12][13][14] . Additionally, we found that the median age of LC-IPTB patients was slightly greater than that of LC-APTB patients, suggesting15 that younger LC patients might be more prone to active pulmonary tuberculosis.…”

Section: Discussionsupporting

confidence: 79%

Clinical characteristics and risk factors for lung cancer in patients with pulmonary tuberculosis

Zhou,

Lin,

Xie

et al. 2024

Preprint

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Lung cancer (LC) and pulmonary tuberculosis (PTB) are significant respiratory diseases with major impacts on public health. LC is the foremost cause of cancer-related mortality in China, while tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide. The increasing occurrence of LC-PTB comorbidities presents new challenges in clinical management. This study investigated the clinical characteristics and risk factors associated with LC-PTB comorbidity to inform future diagnostic and therapeutic strategies. This retrospective study at Guangzhou Chest Hospital reviewed 402 LC-PTB patients from October 2014 to September 2021, with clinical and epidemiological data collected and analyzed from electronic medical records. A total of 75.6% had active pulmonary tuberculosis (APTB), while 24.4% had inactive pulmonary tuberculosis (IPTB). The success rate of APTB treatment was 67.4% (205/304). In the APTB group, PTB lesions were more frequently located on the same side as LC lesions (P < 0.001). Additionally, the incidence of cavitary lesions was greater in the IPTB group than in the APTB group (P < 0.001). Based on different etiological classifications, patients with APTB were divided into bacteria-positive (B+PTB) and bacteria-negative (B−PTB) groups. In the B+PTB group, PTB lesions were more frequently located on the same side as LC lesions (P < 0.001), and cavitary lesions were more common (P < 0.001). Among the LC-B−PTB patients, PTB was detected more often before LC (P < 0.001), and these patients responded better to anti-TB therapy (P < 0.001). According to the subgroup analysis, preexisting APTB (OR = 3.79, 95% CI: 2.16–6.65, P < 0.001) and advanced stages of LC (OR = 3.66, 95% CI: 1.53–8.79, P = 0.004) were identified as potential risk factors for anti-TB therapy failure. LC-PTB patients have unique clinical characteristics that differ according to their activity status and pathogen classification. Preexisting APTB and advanced-stage LC may increase the risk of anti-TB therapy failure.

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Section: Discussionsupporting

confidence: 79%

Clinical characteristics and risk factors for lung cancer in patients with pulmonary tuberculosis

Zhou,

Lin,

Xie

et al. 2024

Preprint

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“…A reverse reaction is the development of a neoplasm and treatment that can induce the reactivation of latent infection with tuberculosis [ 25 , 26 ]. Bhowmik et al [ 27 ] found a 1.64- to 6-fold higher incidence and risk of lung cancer in patients with tuberculosis in comparison with patients without this medical condition. The authors also remarked that both of these diseases are often concomitant and the more frequent occurrence of lung cancer, as well as the lowered immunity due to lung cancer, can predis-pose to infection with Mycobacterium tuberculosis .…”

Section: Discussionmentioning

confidence: 99%

Lung Lesions: Differential Diagnoses Beyond Cancer

Jurczak,

Romaszko-Wojtowicz,

Doboszyńska

2024

Am J Case Rep

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Unusual clinical course Background:Lung cancer is the most common malignant neoplasm diagnosed worldwide. Early diagnosis and treatment are of great importance for patient's prognosis. A wide variety of pulmonary conditions display clinical and radiological presentation similar to that of lung cancer, and the awareness of their existence can help in making correct diagnoses. Case Reports:This article presents a description of 4 patients with an insidious type of lesions mimicking pulmonary carcinomas. The first patient was referred to Department with a tumor-like lesion in the right lung. After CT of the chest and core-needle biopsy, the lesion turned out to be an ectopic thyroid tissue. The second patient reported a dry cough and weight loss. A lung nodule mass was revealed in chest CT and the patient was diagnosed with pulmonary tuberculoma. The remaining 2 patients, despite the suspicion of lung cancer, were subsequently diagnosed with a post-traumatic pleural hematoma and diffuse large B cell lymphoma. Conclusions:Low-dose computed tomography of the chest plays a significant role in the diagnosis of newly detected lesions in the lungs. However, due to the similarity of the image of cancer to that of other diseases, the ultimate diagnosis should be based on the interpretation of full imaging diagnostic tests, clinical presentation, and histopathological examination of the material obtained from the lesion. Analysis of cases enables us to expand our understanding of the diseases that need to be considered in differential diagnosis of a patient with a detected tumor-like lesion in the lungs.

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“…Early diagnosis bias and late treatment strategies for TB might be factors responsible for the high co-occurrence of TB and LC (8)(9)(10)(11). TB diagnosis is performed by QuantiFERON-TB Gold In-Tube tests as a gold standard (5,12).…”

Section: Introductionmentioning

confidence: 99%

Weighted gene co-expression network analysis and whole genome sequencing identify potential lung cancer biomarkers

Abudereheman,

Lian,

Ainitu

2024

Front. Oncol.

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BackgroundTuberculosis (TB) leads to an increased risk of lung cancer (LC). However, the carcinogenetic mechanism of TB remains unclear. We constructed gene co-expression networks and carried out whole-exome sequencing (WES) to identify key modules, hub genes, and the most recurrently mutated genes involved in the pathogenesis of TB-associated LC.MethodsThe data used in this study were obtained from the Gene Expression Omnibus (GEO) and WES. First, we screened LC-related genes in GSE43458 and TB-related genes in GSE83456 by weighted gene co-expression network analysis (WGCNA). Subsequently, we screened differentially expressed genes related to LC and TB in GSE42834. We also performed WES of 15 patients (TB, n = 5; LC, n = 5; TB+LC, n = 5), constructed mutational profiles, and identified differences in the profiles of the three groups for further investigation.ResultsWe identified 278 hub genes associated with tumorigenesis of pulmonary TB. Moreover, WES identified 112 somatic mutations in 25 genes in the 15 patients. Finally, four common genes (EGFR, HSPA2, CECR2, and LAMA3) were confirmed in a Venn diagram of the 278 hub genes and the mutated genes from WES. KEGG analysis revealed various pathway changes. The PI3K–AKT signaling pathway was the most enriched pathway, and all four genes are included in this pathway. Thus, these four genes and the PI3K–AKT signaling pathway may play important roles in LC.ConclusionSeveral potential genes and pathways related to TB-associated LC were identified, including EGFR and three target genes not found in previous studies. These genes are related to cell proliferation, colony formation, migration, and invasion, and provide a direction for future research into the mechanisms of LC co-occurring with TB. The PI3K–AKT signaling pathway was also identified as a potential key pathway involved in LC development.

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Incidence and Risk of Lung Cancer in Tuberculosis Patients, and Vice Versa: A Literature Review of the Last Decade

Cited by 5 publications

References 69 publications

Clinical characteristics and risk factors for lung cancer in patients with pulmonary tuberculosis

Clinical characteristics and risk factors for lung cancer in patients with pulmonary tuberculosis

Lung Lesions: Differential Diagnoses Beyond Cancer

Weighted gene co-expression network analysis and whole genome sequencing identify potential lung cancer biomarkers

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