Incidence and risk factors related to SARS-CoV-2 infection, reinfection, and seroconversion: Analysis of a healthcare workers cohort from a university hospital in Colombia

Nieto, María A.; Caballero, Nohemí; Remolina, Camila I.; Moreno, Sergio; Vega, Daniela; Quintero, Juliana

doi:10.1016/j.ijregi.2023.09.003

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Reinfections were more common in HCWs from high-risk departments. Our study detected a higher rate of reinfections in HCWs than other studies as the current study comprised a much longer time period and implied multiple variants of Omicron [23][24][25][26][27][28][29][30][31]. Also, in the studies performed during Omicron circulation the populations received multiple vaccine doses after the primary schedule [25,26,30,31].…”

Section: Discussionmentioning

confidence: 64%

Hybrid Immunity and the Incidence of SARS-CoV-2 Reinfections during the Omicron Era in Frontline Healthcare Workers

Chivu,

Crăciun,

Pițigoi

et al. 2024

Vaccines

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During the coronavirus disease (COVID-19) pandemic healthcare workers (HCWs) acquired immunity by vaccination or exposure to multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our study is a comparative analysis between subgroups of HCWs constructed based on the number of SARS-CoV-2 infections, vaccination, and the dominant variant of SARS-CoV-2 in the population. We collected and analyzed data using the χ2 test and density incidence of reinfections in Microsoft Excel for Mac, Version 16.84, and MedCalc®, 22.026. Of the 829 HCWs, 70.1% (581) had only one SARS-CoV-2 infection and 29.9% (248) had two infections. Of the subjects with two infections, 77.4% (192) worked in high-risk departments and 93.2% (231) of the second infections were registered during Omicron dominance. The density incidence of reinfections was higher in HCWs vaccinated with the primary schedule than those vaccinated with the first booster, and the incidence ratio was 2.8 (95% CI: 1.2; 6.7). The probability of reinfection was five times lower (95% CI: 2.9; 9.2) in HCWs vaccinated with the primary schedule if the first infection was acquired during Omicron dominance. The subjects vaccinated with the first booster had a density incidence of reinfection three times lower (95% CI: 1.9; 5.8) if the first infection was during Omicron. The incidence ratio in subgroups constructed based on characteristics such as gender, age group, job category, and department also registered significant differences in density incidence. The history of SARS-CoV-2 infection by variant is important when interpreting and understanding public health data and the results of studies related to vaccine efficacy for hybrid immunity subgroup populations.

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Section: Discussionmentioning

confidence: 64%

Hybrid Immunity and the Incidence of SARS-CoV-2 Reinfections during the Omicron Era in Frontline Healthcare Workers

Chivu,

Crăciun,

Pițigoi

et al. 2024

Vaccines

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Long-term dynamics of natural, vaccine-induced, and hybrid immunity to SARS-CoV-2 in a university hospital in Colombia: A cohort study

Caballero,

Monsalve,

Acosta-Ampudia

et al. 2024

Preprint

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This prospective cohort study aimed to estimate the natural, vaccine-induced, and hybrid immunity to SARS-CoV-2, alongside the immunogenicity of the mRNA-1273 booster after the BNT162b2 primary series in healthcare workers in Colombia. IgG, IgA, and neutralizing antibodies were measured in 110 individuals with SARS-CoV-2 infection or a BNT162b2 primary series. Humoral responses and related factors were explored in a subgroup (n = 36) that received a BNT162b2 primary series followed by a mRNA-1273 booster (2BNT162b2 + 1mRNA-1273), and T-cell responses were evaluated in a subgroup of them (n = 16). For natural immunity, IgG and IgA peaked within three months, declining gradually but remaining detectable up to 283 days post-infection. Neutralizing antibody inhibition post-infection was below positive range (≥ 35%) but exceeded 97% in vaccine-induced and hybrid immunity groups. Following 2BNT162b2 + 1mRNA-1273, IgG peaked 3–4 months post-booster, gradually declining but remaining positive over 10 months, with IgA and neutralizing antibodies stable. Age and blood group were related to IgG response, while obesity and blood type to IgA response post-booster. Autoimmunity and blood type B were associated with lower neutralizing antibody inhibition. There were no differences in T-cell responses according to prior infection. These findings provide long-term insights into the immunity against SARS-CoV-2 and the immunogenicity of mRNA vaccines.

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Incidence and risk factors related to SARS-CoV-2 infection, reinfection, and seroconversion: Analysis of a healthcare workers cohort from a university hospital in Colombia

Cited by 2 publications

References 31 publications

Hybrid Immunity and the Incidence of SARS-CoV-2 Reinfections during the Omicron Era in Frontline Healthcare Workers

Hybrid Immunity and the Incidence of SARS-CoV-2 Reinfections during the Omicron Era in Frontline Healthcare Workers

Long-term dynamics of natural, vaccine-induced, and hybrid immunity to SARS-CoV-2 in a university hospital in Colombia: A cohort study

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