Incidence and risk factors of renal dysfunction after liver transplantation in Korea

Kim, S.G.; Kim, H.J.; Lee, J.-P.; Lee, S.G.; Kim, Yong Se; Ahn, Curie; Han, Jin-Suk; Kim, S.; Lee, Jun S.; Suh, Kyung Suk

doi:10.1016/j.transproceed.2004.06.042

Cited by 13 publications

(15 citation statements)

References 9 publications

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“…It has been shown that up to 18% of the patients can develop a glomerular filtration rate (GFR) of <29 ml per min per 1.732 of body surface area (ml/min) by 5 years post-transplantation [5], however, rates vary depending on the definitions used. Some investigators have used the classification outlined in the Kidney Disease Outcomes Quality Initiative (K/DOQI) Guidelines and others have used specific creatinine levels to stratify patients [12][13][14] making interpretation and comparison of results difficult.…”

Section: Introductionmentioning

confidence: 99%

Chronic kidney disease post-liver transplantation

O'Riordan¹,

Wong²,

McCormick³

et al. 2006

Nephrology Dialysis Transplantation

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Section: Introductionmentioning

confidence: 99%

Chronic kidney disease post-liver transplantation

O'Riordan¹,

Wong²,

McCormick³

et al. 2006

Nephrology Dialysis Transplantation

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“…Even relatively mild elevations in pre-transplant creatinine >1.5 mg/dL may portend poor long term renal function. This was confirmed by many investigators (Moreno et al, 2003, Kim et al, 2004and Burra et al, 2009. A multivariate Cox regression analysis performed by Lee et al revealed that the overall risk of CKD development was associated with low pre transplant eGFR in addition to post-transplant acute renal failure (Lee et al, 2010).…”

Section: Pretransplant Renal Dysfunctionmentioning

confidence: 64%

“…Authors Frequency Time post-LT Lee J, et al (2010) Burra P, et al (2009) Kim S, et al (2004) De Boccardo G, et al (2008) 17.6% (76/431) 35.3% (143/406) 43.5% (27/62) 62.3% (144/231) 12 months 12 months 17 months 73 months Table 5. Epidemiology of chronic kidney disease among liver transplant recipients (CKD = eGFR <60 ml/min)…”

Section: Epidemiology Of Chronic Renal Dysfunctionmentioning

confidence: 99%

“…Post-LT ARF was proved to be an early predictor of chronic kidney disease (CKD) in several studies (Ojo et al, 2003;Kim et al, 2004;Burra et al, 2009 andSharma et al, 2009). Barri and his colleagues, 2009 stated clearly that the high incidence of acute kidney injury post-liver transplantation is an important risk factor for long-term renal dysfunction and its associated morbidity and mortality.…”

Section: Postoperative Acute Renal Failure (Arf) and Dialysis Requirementioning

confidence: 99%

“…Many investigators did not identify any difference in the impact of either drug on the immediate postoperative kidney function (Burra et al, 2009, Dehghani et al, 2008, Kim et al, 2004and Wei et al, 2006. On the other hand, O'Riordan et al, 2006 found a beneficial effect of tacrolimus use, compared with cyclosporine, which retarded the progression of acute renal disease to chronic renal disease.…”

Section: Abnormalities In Tubular Function Includementioning

confidence: 99%

See 2 more Smart Citations

Renal Dysfunction and Liver Transplantation

Allam¹

2012

Liver Transplantation - Technical Issues and Complications

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Clinical usefulness of kidney biopsy in liver transplant recipients with renal impairment

Lee

Cho

Ryu

et al. 2013

Kidney Research and Clinical Practice

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BackgroundChronic kidney disease is a common complication after liver transplantation. In this study, we analyzed the results of kidney biopsy in liver transplantation recipients with renal impairment.MethodsBetween 1999 and 2012, 544 liver transplants were performed at our hospital. We retrospectively analyzed the clinical and histological data of 10 liver transplantation recipients referred for kidney biopsy.ResultsThe biopsies were performed at a median of 24.5 months (range, 3–73 months) after liver transplantation. The serum creatinine level was 1.81±0.5 mg/dL at the time of kidney biopsy. There were no immediate complications. The most common diagnosis was glomerulonephritis (GN), such as immunoglobulin A nephropathy (n=4), mesangial proliferative GN (n=1), focal proliferative GN (n=1), and membranous GN (n=1). Typical calcineurin inhibitor (CNI)-induced nephrotoxicity was detected in three cases (30%). Chronic tissue changes such as glomerulosclerosis, interstitial fibrosis, and tubular atrophy were present in 90%, 80%, and 80% of cases, respectively, and mesangial proliferation was detected in 40% of cases. We began treatment for renal impairment based on the result of kidney biopsy; for example, angiotensin-receptor blockers or steroids were prescribed for GN, and the CNI dose was reduced for CNI nephrotoxicity. As a result, eight of 10 patients showed improvement in glomerular filtration rate, but two progressed to end-stage renal disease.ConclusionKidney biopsy is a safe and effective method for determining the cause of renal impairment after liver transplantation. Management of patients based on the result of kidney biopsy may improve renal outcomes.

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Incidence and risk factors of renal dysfunction after liver transplantation in Korea

Cited by 13 publications

References 9 publications

Chronic kidney disease post-liver transplantation

Chronic kidney disease post-liver transplantation

Renal Dysfunction and Liver Transplantation

Clinical usefulness of kidney biopsy in liver transplant recipients with renal impairment

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