Incidence and Risk Factors of Non-Alcoholic Fatty Liver Disease among Non-Obese Patients Attending at Department of Gastroenterology, BSMMU

Biswas, Prodip Kumar; Kabir, Akm Humayon; Karim, Mohammad Enamul; Hossain, Shabbir; Vhadury, Suvash Chandra; Rhaman, Mir Masudur; Masud, Hasan; Khan, Mizanur Rahman

doi:10.3329/jom.v16i2.25433

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 Sedentary life style, metabolic syndrome, diabetes mellitus, and dyslipidameia are risk factors of NAFLD in non-obese persons.6 , 13 Diabetes is also one of the main culprits in the progression to NASH, 14 and liver biopsy is recommended in NAFLD patients who have diabetes and elevated GGT. 14 Although elevated liver enzymes are consequences of NAFLD, 13 male sex, raised ALT, high LDL cholesterol, and insulin resistance are significant and independent factors associated with the presence of NAFLD in T2DM subjects. 15 Furthermore, South Asian populations may be more genetically susceptible via the inheritance of polymorphisms in apolipoprotein-3 that increase IR and cause NAFLD ( Figure -2).…”

Section: Pathogenesis Of Nafld and Diagnosismentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Alam

Hossain

Azam

et al. 2017

J. Bangladesh Coll. Phys.

View full text Add to dashboard Cite

Nonalcoholic Fatty Liver Disease (NAFLD) is the condition where fat accumulates in liver without significant ingestion of alcohol. NAFLD has become one of the most common liver conditions throughout the world. At the dawn of the history of NAFLD it was thought that NAFLD is disease of obese individual but lean patients are increasingly detected to have NAFLD. It seems that insulin resistance is central to the pathogenesis of NAFLD. In addition, oxidative stress and cytokines are important contributing factors, resulting in steatosis and progressive liver damage in genetically susceptible individuals. NAFLD varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. Prevalence of NAFLD in general population of Bangladesh is 4 -18.4 %, which jumps up to 49.8% in diabetic patients. With the changes in socioeconomic condition and life style, aetiology of chronic liver disease is drifting from infectious to noninfectious diseases and the contribution of NAFLD is progressively increasing. Hepatitis B and hepatitis C have been the leading causes of mortality and morbidity from chronic liver disease in Bangladesh. But with increase in awareness and mass vaccination against HBV, prevalence of both the diseases has been decreasing in the country. The most alarming feature is that there is a high prevalence of NASH among the NAFLD patients. NAFLD is emerging as the largest contributor of chronic liver disease in Bangladesh. This warrants the attention of health policy makers and clinicians to explore this frontier and combat it from right now.

show abstract

Section: Pathogenesis Of Nafld and Diagnosismentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Alam

Hossain

Azam

et al. 2017

J. Bangladesh Coll. Phys.

View full text Add to dashboard Cite

show abstract

“…Hepatocellular Carcinoma (HCC) is a serious public health issue and the fourth leading cause of cancer mortality worldwide (Kudo et al, 2014;Suresh et al, 2020). HCC accounts for about 80% of the primary liver cancers while the other types include cholangiocarcinoma (10-20%) and angiosarcoma (1%) (Biswas et al, 2015). There is a striking variation in HCC incidence rate across geographic regions and at the global level.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Promoter methylation of certain tumor regulatory genes and hepatocellular carcinoma

ELazm

2022

Records of Pharmaceutical and Biomedical Sciences

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy of adults and the second responsible cause of cancer-related death around the world. Hepatocellular carcinoma (HCC) accounts for about 90% of primary liver malignancies. In Egypt chronic hepatitis C virus (HCV) is a major health burden and a major risk factor for HCC. Alteration of DNA Methylation at promoter regions has a recognized role during early evolution and development of human diseases, including cancers. It can be in the form of hypermethylation, hypomethylation, and loss of imprinting. RUNX3 and p16 are tumor suppressor genes that may be inactivated by hypermethylation which is a key epigenetic mechanism that contributes to the initiation and progression of various types of human carcinomas including HCC.

show abstract

Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta‐Analysis

et al. 2020

View full text Add to dashboard Cite

Data on prevalence and profile of nonalcoholic fatty liver disease (NAFLD) among individuals who are lean (normal body mass index) is unclear. Published data from studies comparing lean with obese NAFLD or with healthy subjects on prevalence, comorbidities, liver chemistry and histology, and metabolic/inflammatory markers were analyzed. Data were reported as odds ratio and 95% confidence interval for categorical variables and difference of means for continuous variables. Analysis of 53 studies on 65,029 subjects with NAFLD (38,084 lean) and 249,544 healthy subjects showed a prevalence of lean NAFLD at 11.2% in the general population. Among individuals with NAFLD, the prevalence of lean NAFLD was 25.3%. Lean NAFLD versus healthy subjects had higher odds for abnormalities on metabolic profile, including metabolic syndrome and its components, renal and liver function, and patatin-like phospholipase domain-containing protein 3 (PNPLA3) G allele; and inflammatory profile, including uric acid and C-reactive protein.The abnormalities were less severe among lean versus obese NAFLD on metabolic syndrome with its components, renal and liver chemistry, liver stiffness measurement, PNPLA3 and transmembrane 6 superfamily member 2 polymorphisms, and uric acid levels as markers of inflammation. Lean NAFLD had less severe histologic findings, including hepatocyte ballooning, lobular inflammation, NAFLD activity score, and fibrosis stage. Limited data also showed worse outcomes between obese versus lean NAFLD. Conclusion: Lean NAFLD is a distinct entity with metabolic, biochemical, and inflammatory abnormalities compared to healthy subjects and a more favorable profile, including liver histology of steatohepatitis and fibrosis stage, compared to obese NAFLD. We suggest that prospective multicenter studies examine long-term hepatic and extrahepatic outcomes in individuals with lean NAFLD. (Hepatology Communications 2020;4:953-972).N onalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world, with a global prevalence of approximately 25% and a prevalence of 24% in North America. (1,2) The incidence is increasing, especially in the Western world, due to the rising prevalence of obesity in the general population. (3) Approximately 15% to 20% of patients with NAFLD progress to the more advanced stage of nonalcoholic steatohepatitis (NASH), with a risk to progress to advanced liver

show abstract

Incidence and Risk Factors of Non-Alcoholic Fatty Liver Disease among Non-Obese Patients Attending at Department of Gastroenterology, BSMMU

Cited by 3 publications

References 15 publications

Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

Promoter methylation of certain tumor regulatory genes and hepatocellular carcinoma

Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta‐Analysis

Contact Info

Product

Resources

About