Incidence and Risk Factors for Pulmonary Embolism After Primary Musculoskeletal Tumor Surgery

Yasunaga, Hideo; Horiguchi, Hiromasa; Kawano, Hirotaka

doi:10.1007/s11999-013-3073-9

Cited by 16 publications

(9 citation statements)

References 26 publications

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“…Both active malignancy and major surgical procedures are independent risk factors for the development of VTE. Previous studies have found that postoperative thromboembolic complications span all surgical specialties, 3 with high rates following major musculoskeletal surgery 4–7 . This increases morbidity and mortality for patients undergoing these types of procedures 8 .…”

Section: Introductionmentioning

confidence: 99%

Venous thromboembolism rates in patients with bone and soft tissue sarcoma of the extremities following surgical resection: A systematic review

Krzyzaniak

You

Mosca

et al. 2021

Journal of Surgical Oncology

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Background: Patients undergoing an orthopedic surgery for bone or soft tissue sarcoma are at increased venous thromboembolism (VTE) risk. Unfortunately, there is a lack of thromboprophylaxis guidelines in this population. The purpose of this systematic review was to determine the soft tissue and bone sarcoma VTE rate and to explore the thromboprophylaxis regimens used.Methods: The databases MEDLINE, EMBASE, and CENTRAL were queried using keywords related to VTE and long bone malignancy requiring surgical intervention to 2020. Included studied reported VTE rate in patients with surgically managed extremity sarcoma. Descriptive statistics and weighted mean totals were calculated.Results: A total of 2082 studies were screened and 23 studies were included. The overall VTE rate was 2.9%, with a rate of 3.7% and 1.4% in patients with bone and soft tissue sarcomas, respectively. Low-molecular-weight heparin was the most commonly used chemoprophylaxis.Conclusions: There is a high VTE rate following sarcoma surgery. The VTE rate is higher in bone sarcoma surgery, which may be attributed to differences in surgery and postoperative recovery. There was no consensus on the duration or type of thromboprophylaxis used. Future research is needed to determine the most effective thromboprophylaxis regimen in patients with sarcoma and whether individualized thromboprophylaxis is required.

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Section: Introductionmentioning

confidence: 99%

Venous thromboembolism rates in patients with bone and soft tissue sarcoma of the extremities following surgical resection: A systematic review

Krzyzaniak

You

Mosca

et al. 2021

Journal of Surgical Oncology

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“…However, the study team persevered and identifi ed that potentially primary malignant bone tumours were associated with higher risk than soft-tissue sarcomas (OR 5.58). Bone tumour resection (OR 7.94) and prosthetic reconstruction (OR 9.15) were associated with a signifi cantly higher risk of PE than soft-tissue tumour resection 4. This study raises more questions than it answers as the authors (and indeedthe readership) are likely to be fl abbergasted by the low incidence of PE in this group.…”

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confidence: 86%

Oncology

2013

Bone & Joint 360

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“…The Diagnosis Procedure Combination database is a national administrative claims and discharge abstract data on acute-care inpatients in Japan, the details of which have been described [6,8,13,14]. Data were collected during 6 months (from July 1 to December 31) until 2010 and throughout the year from 2011.…”

Section: Data Sourcementioning

confidence: 99%

What Is the Effect of Advanced Age and Comorbidity on Postoperative Morbidity and Mortality After Musculoskeletal Tumor Surgery?

Yasunaga

Horiguchi

Fushimi

et al. 2014

Clin Orthop Relat Res

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Background Although the elderly population is increasing rapidly, little information is available regarding how the risk of postoperative mortality and morbidity increases when combined with age and comorbidity burden in patients undergoing musculoskeletal tumor surgery. Questions/purposes We evaluated the effect of age and comorbidity burden on the (1) postoperative complication rate and (2) in-hospital mortality rate after musculoskeletal tumor surgery. Methods We identified 5716 patients undergoing musculoskeletal tumor surgery during 2007 to 2012 using a Japanese national inpatient database. Logistic regression analyses were performed to examine the relationships of various factors with the rates of mortality and morbidity. Results The postoperative complication rate (6.7%) was associated with male sex (p = 0. The morbidity (21.6%; OR, 3.29; p \ 0.001) and mortality (4.1%; OR, 5.95; p \ 0.001) in patients 80 years or older with a Charlson Comorbidity Index of 4 or greater was increased three and six times, respectively, compared with patients 64 years or younger with no comorbidity. Conclusions We found that age and comorbidity burden together greatly increased the risk of morbidity and mortality. Our study showed quantitative evidence that will assist physicians in assessing perioperative risk accurately and provide a more informative explanation to elderly patients undergoing musculoskeletal tumor surgery. Level of Evidence Level IV, prognostic study. See the Instructions for Authors for a complete description of levels of evidence.

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Incidence and Risk Factors for Pulmonary Embolism After Primary Musculoskeletal Tumor Surgery

Cited by 16 publications

References 26 publications

Venous thromboembolism rates in patients with bone and soft tissue sarcoma of the extremities following surgical resection: A systematic review

Venous thromboembolism rates in patients with bone and soft tissue sarcoma of the extremities following surgical resection: A systematic review

Oncology

What Is the Effect of Advanced Age and Comorbidity on Postoperative Morbidity and Mortality After Musculoskeletal Tumor Surgery?

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