Incidence and risk factors for vertebral fracture in rheumatoid arthritis: an update meta-analysis

Liu, Yang; Jiang, Jun; Mo, Minmin; Sun, Xiaohong; Yu, Kailong

doi:10.1007/s10067-021-06046-2

Cited by 5 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the high risk of vertebral fractures for RA patients (OR 3.04) [ 7 ], only a few studies evaluated the effect of different treatment regimens on vertebral fracture risk. A population-based retrospective cohort study showed that in RA patients with cardiovascular disease, low-dose corticosteroids (HR 0.57) as well as hydroxychloroquine (HR 0.12) lowered the risk of vertebral fractures [ 101 ].…”

Section: Proof Of Concept: Human Pharmacologic Intervention Studiesmentioning

confidence: 99%

“…A meta-analysis conducted by Jin et al, in patients with RA revealed an increased risk of fragility fractures (relative risk: 1.61) [ 6 ]. Vertebral fractures are the most frequent type of osteoporotic fractures; a recent meta-analysis found a 20% prevalence of vertebral fractures in RA patients, with the Odd’s ratio (OR) as high as 3.04 (confidence interval: 1.97–4.71) [ 7 ]. Bone fragility in RA results from both low bone mineral density (BMD) and from a severely deteriorated bone structure [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis

Pietschmann

Butylina

Kerschan‐Schindl

et al. 2022

IJMS

View full text Add to dashboard Cite

Rheumatoid arthritis (RA), an autoimmune disease, is characterized by the presence of symmetric polyarthritis predominantly of the small joints that leads to severe cartilage and bone destruction. Based on animal and human data, the pathophysiology of osteoporosis, a frequent comorbidity in conjunction with RA, was delineated. Autoimmune inflammatory processes, which lead to a systemic upregulation of inflammatory and osteoclastogenic cytokines, the production of autoantibodies, and Th cell senescence with a presumed disability to control the systemic immune system’s and osteoclastogenic status, may play important roles in the pathophysiology of osteoporosis in RA. Consequently, osteoclast activity increases, osteoblast function decreases and bone metabolic and mechanical properties deteriorate. Although a number of disease-modifying drugs to treat joint inflammation are available, data on the ability of these drugs to prevent fragility fractures are limited. Thus, specific treatment of osteoporosis should be considered in patients with RA and an associated increased risk of fragility fractures.

show abstract

Section: Proof Of Concept: Human Pharmacologic Intervention Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis

Pietschmann

Butylina

Kerschan‐Schindl

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…In a subgroup analysis according to site, positive associations were shown between RA and vertebral fracture (RR 2.93, 95% CI 2.25-3.83) and RA and hip fracture (RR 2.41, 95% CI 1.83-3.17) (10). In a meta-analysis of 11 studies (involving 3,805 RA cases and 59,517 controls), RA was positively associated with vertebral fracture prevalence (20.29% RA cases versus 8.63% controls; OR 3.04, 95% CI 1.97-4.71) (25).…”

Section: Discussionmentioning

confidence: 99%

Association Between Rheumatoid Arthritis and Osteoporosis in Japanese Populations: A Mendelian Randomization Study

Deng

Wong

2023

Arthritis & Rheumatology

View full text Add to dashboard Cite

Objective The positive association between rheumatoid arthritis (RA) and osteoporosis has been reported in previous observational studies, but the causal relationship remains unclear. This study was undertaken to investigate whether RA was causally associated with osteoporosis in Japanese populations using Mendelian randomization (MR) analyses. Methods Publicly available summarized data from genome‐wide association studies (GWAS) on RA (4,199 cases and 208,254 controls) and osteoporosis (7,788 cases and 204,665 controls) were obtained from BioBank Japan. Eleven RA‐related single‐nucleotide polymorphisms (P < 5×10−8) were selected as instrumental variables. We used the inverse variance–weighted method as the primary method to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs). We also used the MR–Egger's method, weighted median, and weighted mode to determine the robustness of the main results. To partially test the horizontal pleiotropy, we used the MR–Egger's intercept test and the Mendelian randomization pleiotropy residual sum and outlier (MRPRESSO) test. Results Using the inverse variance–weighted method, we showed that genetically predicted RA was positively associated with osteoporosis (OR 1.10, 95% CI 1.06–1.14, P < 0.001). The positive association was robust when we tested the results using the MR–Egger's method (OR 1.09, 95% CI 1.03–1.16, P = 0.023), weighted median (OR 1.09, 95% CI 1.04–1.15, P < 0.001), and weighted mode (OR 1.08, 95% CI 1.03–1.13, P = 0.012). Horizontal pleiotropy was not detected (P = 0.737) by the MR–Egger's intercept test or the MRPRESSO test. Conclusion Our results show a potential causal association between genetically predicted RA and osteoporosis. The finding was consistent when we used different MR methods and the sensitivity analysis. Further MR studies are needed when GWAS with more details of RA and osteoporosis performed in other East Asian/Japanese populations are available.

show abstract

“…1 RA is the most prevalent chronic autoimmune disease that primary affects small joints of hand leading to bone, cartilage, and articular deformities. 2 Many cytokines and effector cells infiltrate the synovial membrane leading to synovitis which is the hallmark of RA. 3 .…”

Section: Introductionmentioning

confidence: 99%

Galectin-1 in Psoriatic arthritis, Psoriasis, Rheumatoid arthritis and its relation with disease activity and skin lesion

Bably

Aziz

Adly

et al. 2023

EJI

View full text Add to dashboard Cite

Immune mediated inflammatory diseases (IMIDs) are a diverse range of diseases that affect joints with early overlapping symptoms. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are the most common disorders sharing immune-pathogenic mechanisms that cause peripheral arthritis. Psoriasis (Ps) is a chronic inflammatory autoimmune skin disease characterized by epidermal hyperplasia with significant invasion by inflammatory cells. New biomarkers are required to enable an early diagnosis and differentiation between different types of IMIDs. In autoimmune disorders, galectin 1 (Gal-1) is a recognized as negative immune system regulator. This study aimed to determine the possibility of using gal–1 as a diagnostic marker to differentiate between RA and PsA with polyarthritis pattern, and between PsA and Ps, and to assess its relationship with disease activity and with skin lesion. In this case-control study included 40 PsA patients with polyarthritis pattern, 40 psoriatic patients, 40 RA patients and 20 normal controls. Gal-1 levels were measured in serum and skin biopsy and disease Activity Score (DAS-ESR) was assessed. Serum gal-1 level was significantly higher in RA group in comparison to PsA, psoriatic and control. In addition, compared to the normal group, psoriatic skin lesions from PsA and Ps patients had lower levels of gal-1. Serum gal-1 levels in the RA group did not correlate with other factors such as age, disease duration, deformity, extra-articular symptoms, or DAS-ESR. Furthermore, there was no correlation between the skin’s level of gal-1 and psoriatic area and severity index (PASI) score, body surface area (BSA). In conclusion, serum Gal-1 concentration may serve as a diagnostic biomarker to distinguish between RA and PsA. However, it cannot assess activity or severity of RA, and cannot differentiate psoriatic lesion either from only Ps or PsA.

show abstract

Incidence and risk factors for vertebral fracture in rheumatoid arthritis: an update meta-analysis

Cited by 5 publications

References 45 publications

Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis

Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis

Association Between Rheumatoid Arthritis and Osteoporosis in Japanese Populations: A Mendelian Randomization Study

Galectin-1 in Psoriatic arthritis, Psoriasis, Rheumatoid arthritis and its relation with disease activity and skin lesion

Contact Info

Product

Resources

About