Incidence and risk factors for mortality in patients treated with combined ceftaroline for Gram-positive infective endocarditis

Brandariz-Núñez, David; Suanzes, Jorge; Gutiérrez-Urbón, José-María; Fernández-Oliveira, Carla; Margusino, Luis; Martín‐Herranz, Isabel

doi:10.1007/s10096-022-04443-2

Cited by 2 publications

(1 citation statement)

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“…), all of which were CPT in vitro susceptible, with a 30% overall in-hospital mortality rate and a 38.6% treatment failure ate at 42 days. CPT was used in combination, mostly with DAP, at a dosage of 600 mg every 8 h or 12 h (or adjusted based on renal function) [64].…”

Section: Clinical Evidence In Infective Endocarditismentioning

confidence: 99%

New Antimicrobials and New Therapy Strategies for Endocarditis: Weapons That Should Be Defended

Oliva,

Cogliati Dezza,

Cancelli

et al. 2023

JCM

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The overall low-quality evidence concerning the clinical benefits of different antibiotic regimens for the treatment of infective endocarditis (IE), which has made it difficult to strongly support or reject any regimen of antibiotic therapy, has led to a discrepancy between the available guidelines and clinical practice. In this complex scenario, very recently published guidelines have attempted to fill this gap. Indeed, in recent years several antimicrobials have entered the market, including ceftobiprole, ceftaroline, and the long-acting lipoglycopeptides dalbavancin and oritavancin. Despite being approved for different indications, real-world data on their use for the treatment of IE, alone or in combination, has accumulated over time. Furthermore, an old antibiotic, fosfomycin, has gained renewed interest for the treatment of complicated infections such as IE. In this narrative review, we focused on new antimicrobials and therapeutic strategies that we believe may provide important contributions to the advancement of Gram-positive IE treatment, providing a summary of the current in vitro, in vivo, and clinical evidence supporting their use in clinical practice.

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Section: Clinical Evidence In Infective Endocarditismentioning

confidence: 99%