Incidence and risk factors for stroke in patients with COVID-19 in the Philippines: An analysis of 10,881 cases

Jamora, Roland Dominic G.; Prado, Mario B.; Anlacan, Veeda Michelle M.; Sy, Marie Charmaine C.; Espiritu, Adrian I.

doi:10.1016/j.jstrokecerebrovasdis.2022.106776

Cited by 13 publications

(22 citation statements)

References 23 publications

(56 reference statements)

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“…This conclusion is consistent with prior studies on COVID-19 stroke patients who had a higher fatality rate than those who did not have stroke, both hemorrhagic and ischemic stroke. 4,5,12 Dyspnea, smoking, cardiovascular problems, kidney and liver diseases, hypertension, diabetes, and malignancy were all signi cantly related with elevated mortality rates in COVID-19. 14 The prevalence was higher in elderly patients.…”

Section: Discussionmentioning

confidence: 97%

“…18 On the contrary, a history of hypertension with mean elevated blood pressure showed that systolic hypertension was related with a substantially greater risk of mortality and an increased incidence of intensive care unit (ICU) admission in patients with COVID-19. 4,19 In COVID-19 stroke patients, a decrease of consciousness, as well as focal and general neurological de cits were found to increase the risk of mortality. Previous studies identi ed the GCS score as a risk factor for predicting mortality and allowing rapid risk strati cation for SARS-CoV-2 infected stroke patients in tertiary care hospitals in low-middle-income countries where laboratory ndings may be unavailable during crisis.…”

Section: Discussionmentioning

confidence: 99%

“…9 Death is more common in acute stroke patients with COVID-19. 4,5 In individuals with COVID-19, the risk of mortality doubles with the occurence of acute ischemic stroke. 5 COVID-19 patients with stroke tended to have poor outcomes due to limited admission to intensive care facilities and use of ventilators.…”

mentioning

confidence: 99%

“…11 Mortality in stroke patients with COVID-19 is further associated with older age, dyspnea, smoking, kidney disease, hypertension, malignancy, diabetes mellitus (DM), and lung disease. 4,10 Several laboratory markers from previous studies have become predictors of COVID-19 mortality, such as increased D-dimer, decreased platelet count, decreased hemoglobin concentration, increased creatinine, increased Interleukin-6 (IL-6), and elevated cardiac troponin-I. 12 Other predictors are albumin, total bilirubin, Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), nitrogen urea (p-ES), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin levels.…”

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confidence: 99%

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Degree of COVID-19 Severity and Mortality in Stroke: Correlation of Clinical and Laboratory Parameters

Gofir,

Syamsah,

Setyawan

et al. 2023

Preprint

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Background Stroke is one of the neurological manifestations of COVID-19. Acute stroke patients with COVID-19 had a significant morbidity and mortality. The clinical and laboratory data of these patients were investigated to determine the key factors in predicting mortality. Method This retrospective case-control study was conducted at Dr. Sardjito General Hospital Yogyakarta, Indonesia using data from July 2020 - August 2021. All acute stroke patients with confirmed COVID-19 were included. Patients’ medical records were used to collect the clinical and laboratory data. For baseline characteristics, univariate tests were used, followed by bivariate and multivariate analyses to determine significant predictors of mortality. Result We included a total of 72 subjects, consisting of 65 (90.28%) subjects with ischemic stroke and 7 (9.72%) with hemorrhagic stroke. The overall mortality rate was 58.3%, which consisted of 50% ischemic and 8.3% hemorrhagic stroke cases. Lowered Glasgow Coma Scale (GCS), loss of consciousness, generalized seizures, worsened modified Ranking Scale (mRS), history of dyslipidemia, worsened clinical severity of COVID-19 infection, respiratory distress, higher neutrophil count, C-Reactive Protein levels (> 41mg/dl), Blood Urea Nitrogen (> 29.05mg/dl), and Random Blood Glucose level (> 111.5mg/dl) at admission were all significantly associated with mortality (p < 0.05). Cox regression analysis revealed a 17.535 higher risk of mortality in individuals with severe COVID-19 (p = 0.032). Higher mRS scores more than doubled the probability of mortality (p = 0.001). Conclusion The poorer functional status assessed by mRS and the greater degree of COVID-19 on admission should be carefully identified since they may increase the risk of mortality in stroke patients with COVID-19.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Degree of COVID-19 Severity and Mortality in Stroke: Correlation of Clinical and Laboratory Parameters

Gofir,

Syamsah,

Setyawan

et al. 2023

Preprint

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“…Most countries in Latin-American (Argentina, Brasil, Chile, Colombia, Peru y Paraguay) reported mild decreases in all-type stroke admissions during the COVID-19 period, except Mexico, where admissions significantly increased in 2020, probably due to a redistribution of admissions to hospitals classified as non-COVID-19 centers. [ 4 5 6 ]…”

mentioning

confidence: 99%