Incidence and Risk Factors for Radiotherapy-Induced Oral Mucositis Among Patients With Nasopharyngeal Carcinoma: A Meta-Analysis

Li, Juejin; Zhu, Chuanmei; Zhang, Yun; Guan, Chunlin; Wang, Qi; Ding, Yuxin; Hu, Xiaolin

doi:10.1016/j.anr.2023.04.002

Cited by 3 publications

(1 citation statement)

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“…It allows the preservation of organs and avoids disfigurement, benefiting approximately 75% of patients with HNC (Alfouzan, 2021). However, radiotherapy also causes damage to normal tissues while antitumour, and diverse toxic side effects often secondary to the treatment, with radiation-induced oral mucositis being one of the most prominent adverse events (Juvkam et al, 2023;Li, Zhu, et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Zhang,

Li,

Zhang

et al. 2024

Journal of Clinical Nursing

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Aims and ObjectivesTo assess the effectiveness of different nonpharmacological treatments for severe radiation‐induced oral mucositis in patients with head and neck cancer.BackgroundRadiation‐induced oral mucositis is highly prevalent in patients with head and neck cancer. Current medications for radiation‐induced oral mucositis are limited in effectiveness and susceptible to side effects, and while there is an increasing adoption of nonpharmacological interventions, the optimal one remains unclear.DesignSystematic review and network meta‐analysis based on the PRISMA‐NMA guidelines.MethodsSix databases were searched. Two authors independently performed the literature screening, data extraction and methodological quality assessment of the included studies. Traditional pairwise meta‐analysis was performed by R Studio. A network meta‐analysis was then conducted to assess the effects of nonpharmacological interventions for severe radiation‐induced oral mucositis in patients with head and neck cancer.ResultsFifty‐two studies involving seven types of nonpharmacological interventions were enrolled. The network meta‐analysis indicated that natural plant‐based therapies might be the most effective, health education interventions might be the second most effective, and honey might be the third most effective interventions for reducing the incidence of severe radiation‐induced oral mucositis. For reducing the incidence of severe oral mucositis‐related pain, the pairwise meta‐analysis showed that only natural plant‐based therapies and health education interventions were effective.ConclusionsNonpharmacological interventions are effective in the management of severe radiation‐induced oral mucositis among patients with head and neck cancer.Relevance to clinical practiceNonpharmacological interventions are a category of safe and effective adjunctive therapies that should be encouraged in clinical practice.Trial registration detailsCRD42023400745.

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Section: Introductionmentioning

confidence: 99%