Incidence and risk factors for cancer after liver transplantation

Hernández, Gonzalo; Romero, Carlos Jiménez; Vicente, Juan Carlos de

doi:10.1016/j.critrevonc.2004.12.011

Cited by 92 publications

(75 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The development of DN after LT has been described by some transplant groups [4,[7][8][9]. The first studies reported an incidence of 3-5% [10][11][12]; however, this has appeared to be higher, up to 22% [7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centre

et al. 2010

View full text Add to dashboard Cite

Purpose Survival post-liver transplantation (LT) has improved; however, patients are considered at the, risk of malignancy due to prolonged immunosuppression. The long-term outcome of patients developing de novo neoplasm (DN) at our centre was evaluated. Methods Between October 1988 and December 2007, 800 LT were performed in 742 patients. Patients were divided into two study periods according to the time of LT; first: October 1988-December 1995; second: January 1996-December 2007.Results After a mean follow-up of 5 ± 4.6 years, 71 DN (9.5%) were detected in 742 patients. The cumulative risk of DN development increased with the time from LT although no differences at 3, 5, and 10 years were found when first and second periods were compared (3, 7, 16% vs. 2, 4, 11%, respectively; p = 0.4). DN incidence was higher in the first compared with the second period (10.7 vs. 7.8%; p \ 0.04); no significant differences were observed in mortality rate (50 vs. 27%; p = 0.052). Actuarial patient survival post-DN at 1, 3, and 5 years: 67, 48, 45% versus 82, 71, 65%, in the first versus second period, respectively, p \ 0.04.Conclusions DN incidence has decreased in recent years; however, as survival post-LT increases, so does the incidence of DN. Surveillance programmes are necessary to diagnose DN at early stages.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Our group recently reported that DN represented the third cause of late mortality post-LT [6]. The development of DN has been ascribed to a multifactorial combination of individual and regional predispositions to malignancy, pretransplantation disease states, recipient viral status, and the use of different immunosuppression regimens [7].…”

Section: Introductionmentioning

confidence: 99%

Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centre

et al. 2010

View full text Add to dashboard Cite

show abstract

“…29,30,[33][34][35] The incidence is extremely high in the Australian reports and is lowest in the Japanese studies. 34 The overall incidence reported from various studies ranges from 30% to 70% for all tumors after LTx.…”

Section: Brief Description Of the Differences In The Incidence Of Varmentioning

confidence: 98%

“…Nonmelanoma, non-Kaposi's skin cancers (squamous cell cancer and basal cell carcinoma) are the commonest types of de novo malignancies in the posttransplant population, with an up to 70 times higher incidence in comparison with nontransplant populations. 24,30,[33][34][35] One way to report this is to separate lymphoid lesions from nonlymphoid cancers and then separate the nonlymphoid cancers. Even after stratification of lymphoid and nonlymphoid cancers in this manner, there appears to be a wide variation in the different types of de novo cancers.…”

Section: See Article On Page 1428mentioning

confidence: 99%

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

2008

View full text Add to dashboard Cite

“…De novo neoplasia is a frequent complication in liver transplant recipients and occurs in 4.7% to 15.7% of patients [16]. It is also one of the most frequent causes of death in long-term survivors, accounting for 25% of the deaths among patients who have survived more than 3 years after orthotopic liver transplant.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Bone Tumor of the Scapula in a Patient Undergoing Liver Transplantation

Ding

Zhang

Kang

et al. 2012

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background De novo malignancies are serious complications in the late postoperative period after liver transplantation. The most common de novo tumors are skin malignancies, posttransplantation lymphoproliferative disorder, tumors of the head and neck, and Kaposi's sarcoma. Such posttransplant de novo malignancies are apparently rarely found in bone. Case Description We describe a patient with a low-grade, aggressive fibrous histiocytoma of the scapula. The patient had undergone liver transplantation 6 years earlier. En bloc resection of the tumor and limb salvage was performed. At the 2-year followup the patient had no signs of local recurrence or metastatic spread; the patient had a Musculoskeletal Tumor Society (MSTS) score of 87.Literature Review A literature review suggests the main predisposing factors to such malignancies are immunosuppression and its length of use. According to the literature, tumors apparently are rare in bone after liver transplantation, with no clearly documented cases. However, in the presence of such a finding, our study might be the first clearly documented case study of this kind of bone tumor. Clinical Relevance We describe a patient with a bone tumor after liver transplantation. Our literature review suggests liver transplantation and long-term immunosuppression played a role in this patient's tumor.

show abstract

Incidence and risk factors for cancer after liver transplantation

Cited by 92 publications

References 89 publications

Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centre

Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centre

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

Case Report: Bone Tumor of the Scapula in a Patient Undergoing Liver Transplantation

Contact Info

Product

Resources

About