Incidence and risk factors for venous thromboembolism, bleeding, and death in colorectal cancer (Cancer‐VTE Registry)

Abstract

The impact of venous thromboembolism in Japanese colorectal cancer patients has not been elucidated. This prespecified subanalysis of the Cancer‐VTE Registry aimed to report venous thromboembolism and event data after 1 year of follow‐up in 2477 patients with colorectal cancer and investigate risk factors of venous thromboembolism. Of 2477 patients, 158 (6.4%) had venous thromboembolism in venous thromboembolism screening at enrollment. Asymptomatic distal deep‐vein thrombosis accounted for 123/158 (77.8%) of venous thromboembolism cases. During the follow‐up period, symptomatic, incidental events requiring treatment and composite venous thromboembolism incidences were 0.3%, 0.8%, and 1.0%, respectively. The incidence of bleeding events, cerebral infarction/transient ischemic attack/systemic embolic event, and all‐cause death were 1.0%, 0.3%, and 4.8%, respectively. These results were consistent with the main study results. In multivariable analysis, venous thromboembolism at baseline was a risk factor of composite venous thromboembolism during the follow‐up period. Japanese patients with colorectal cancer and advancing cancer stage before treatment had more frequent venous thromboembolism complications at baseline, higher incidence of venous thromboembolism events during cancer treatment, and higher mortality.

A nomogram to predict the risk of venous thromboembolism in patients with colon cancer in China

“…These tissue factors can convert PLT into thrombin, which in turn aggravate the severity of bleeding caused by the clotting system, leading to a prolonged time required for plasma coagulation. This relationship between PLT levels and VTE differs from the findings of Masataka Ikeda et al., 11 who reported a correlation between higher PLT levels and the presence of VTE in univariable analysis. The variation in the study sample could account for this inconsistency.…”

“…While the proportion of patients in Stage IV was less than patients in Stages II and III in the Masataka Ikedal et al. 's study 11 . Furthermore, our results revealed that patients with VTE were associated with lower APTT level.…”

“…Discrepancies in results among these studies can likely be attributed to differences in population size, study design, and methodologies employed. 11,27 It is essential to recognize that findings from these studies may not be directly applicable to colon cancer patients in China. The nomogram could simplify the prediction of the outcome event by transforming a complicated regression equation into a visually intuitive graph.…”

“…Various studies have reported on the VTE risk in colon cancer patients in other countries. Discrepancies in results among these studies can likely be attributed to differences in population size, study design, and methodologies employed 11,27 . It is essential to recognize that findings from these studies may not be directly applicable to colon cancer patients in China.…”

Enhancing thromboprophylaxis after colorectal cancer surgery in China: Bridging the gap between evidence and implementation through pathway optimization

“…Venous thromboembolism (VTE), which manifests itself as deep vein thrombosis (DVT) and/or pulmonary embolism (PE), is a frequent and severe complication in individuals with colorectal cancer (CRC), particularly in those who undergo surgery. 1 Both tumor and surgical factors independently contribute significantly to the risk of VTE. 2 It is important to note that VTE is the leading cause of postoperative mortality in patients with CRC.…”